Isolation and characterization of clonal vascular smooth muscle cell lines from spontaneously hypertensive and normotensive rat aortas

1991 ◽  
Vol 27 (10) ◽  
pp. 791-798 ◽  
Author(s):  
Keith L. Hall ◽  
Joseph W. Harding ◽  
Howard L. Hosick
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Spontaneously Hypertensive ◽  
Isolation And Characterization

scholarly journals Erratum: Lazar-Karsten, P., et al. Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve. Cells 2016, 5, 19.

Cells ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 36
Author(s):  
Pamela Lazar-Karsten ◽  
Gazanfer Belge ◽  
Detlev Schult-Badusche ◽  
Tim Focken ◽  
Arlo Radtke ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Bicuspid Aortic Valve

scholarly journals Characterization of nobel vascular smooth muscle cell lines

1997 ◽  
Vol 73 ◽  
pp. 203
Author(s):  
Masuda Tsuyoshi ◽  
Ohmi Kazuhiro ◽  
Yamaguchi Hideki ◽  
Matsuda Yuzuru ◽  
Iino Masamitsu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell

scholarly journals Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve

Cells ◽  
2016 ◽  
Vol 5 (2) ◽  
pp. 19 ◽  
Author(s):  
Pamela Lazar-Karsten ◽  
Gazanfer Belge ◽  
Detlev Schult-Badusche ◽  
Tim Focken ◽  
Arlo Radtke ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Bicuspid Aortic Valve

scholarly journals Enhanced Parenchymal Arteriole Tone and Astrocyte Signaling Protect Neurovascular Coupling Mediated Parenchymal Arteriole Vasodilation in the Spontaneously Hypertensive Rat

2015 ◽  
Vol 35 (7) ◽  
pp. 1127-1136 ◽  
Author(s):  
Jennifer A Iddings ◽  
Ki Jung Kim ◽  
Yiqiang Zhou ◽  
Haruki Higashimori ◽  
Jessica A Filosa
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Metabotropic Glutamate Receptor ◽  
Brain Slices ◽  
Neurovascular Coupling ◽  
Receptor Activation ◽  
Spontaneously Hypertensive

Functional hyperemia is the regional increase in cerebral blood flow upon increases in neuronal activity which ensures that the metabolic demands of the neurons are met. Hypertension is known to impair the hyperemic response; however, the neurovascular coupling mechanisms by which this cerebrovascular dysfunction occurs have yet to be fully elucidated. To determine whether altered cortical parenchymal arteriole function or astrocyte signaling contribute to blunted neurovascular coupling in hypertension, we measured parenchymal arteriole reactivity and vascular smooth muscle cell Ca2+ dynamics in cortical brain slices from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. We found that vasoconstriction in response to the thromboxane A2 receptor agonist U46619 and basal vascular smooth muscle cell Ca2+ oscillation frequency were significantly increased in parenchymal arterioles from SHR. In perfused and pressurized parenchymal arterioles, myogenic tone was significantly increased in SHR. Although K+-induced parenchymal arteriole dilations were similar in WKY and SHR, metabotropic glutamate receptor activation-induced parenchymal arteriole dilations were enhanced in SHR. Further, neuronal stimulation-evoked parenchymal arteriole dilations were similar in SHR and WKY. Our data indicate that neurovascular coupling is not impaired in SHR, at least at the level of the parenchymal arterioles.

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