Acquisition of in vitro growth autonomy during B16 melanoma malignant progression is associated with autocrine stimulation by transferrin and fibronectin

1995 ◽  
Vol 31 (3) ◽  
pp. 244-251 ◽  
Author(s):  
Christopher W. Stackpole ◽  
Suraj S. Kalbag ◽  
Laura Groszek
Keyword(s):  
B16 Melanoma ◽  
Malignant Progression ◽  
In Vitro Growth ◽  
Autocrine Stimulation ◽  
Growth Autonomy

Malignant progression of B16 melanoma cells induced in vitro by growth factors produced by highly malignant cells

1995 ◽  
Vol 13 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Christopher W. Stackpole ◽  
Laura Groszek ◽  
Suraj S. Kalbag
Keyword(s):  
Growth Factors ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Malignant Progression ◽  
Malignant Cells ◽  
B16 Melanoma Cells

Effect of in Vivo Oxidized Cellulose on in Vitro Growth of Human Respiratory Mucosa and Sub-mucosa During Endoscopic Skull Base Approaches

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Ezequiel Goldschmidt ◽  
Jorge Rasmussen ◽  
Joseph Chabot ◽  
Monica Loressi ◽  
Marcelo Ielpi ◽  
...  
Keyword(s):  
Skull Base ◽  
Oxidized Cellulose ◽  
In Vitro Growth ◽  
Respiratory Mucosa

In vitro growth analysis of zea mays l. Using silver nanoparticles

2017 ◽  
Vol 8 (3) ◽  
Author(s):  
SRIRAM. T ◽  
PANDIDURAI. V
Keyword(s):  
Silver Nanoparticles ◽  
Zea Mays ◽  
Growth Analysis ◽  
Zea Mays L ◽  
In Vitro Growth

In vitro growth culture in a medium with reduced sodium chloride improves maturation and developmental competence of pig oocytes derived from small antral follicles

2021 ◽  
Vol 165 ◽  
pp. 37-43
Author(s):  
Hyeji Shin ◽  
Yongjin Lee ◽  
Joohyeong Lee ◽  
Seung Tae Lee ◽  
Geun-Shik Lee ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Developmental Competence ◽  
In Vitro Growth ◽  
Antral Follicles

scholarly journals A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer

Oncogene ◽  
2021 ◽  
Author(s):  
Jinguo Zhang ◽  
Wencai Guan ◽  
Xiaolin Xu ◽  
Fanchen Wang ◽  
Xin Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Calcium Binding ◽  
Molecular Mechanisms ◽  
Epithelial Mesenchymal Transition ◽  
Malignant Progression ◽  
Bioinformatics Analyses ◽  
Aberrant Expression ◽  
Mesenchymal Transition ◽  
E Box

AbstractThe primary chemotherapy of ovarian cancer (OC) often acquires chemoresistance. Sorcin (SRI), a soluble resistance-related calcium-binding protein, has been reported to be an oncogenic protein in cancer. However, the molecular mechanisms of SRI regulation and the role and aberrant expression of SRI in chemoresistant OC remain unclear. Here, we identified SRI as a key driver of paclitaxel (PTX)-resistance and explored its regulatory mechanism. Using transcriptome profiles, qRT-PCR, proteomics, Western blot, immunohistochemistry, and bioinformatics analyses, we found that SRI was overexpressed in PTX-resistant OC cells and the overexpression of SRI was related to the poor prognosis of patients. SRI was a key molecule required for growth, migration, and PTX-resistance in vitro and in vivo and was involved in epithelial–mesenchymal transition (EMT) and stemness. Mechanistic studies showed that miR-142-5p directly bound to the 3ʹ-UTR of SRI to suppress its expression, whereas a transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) inhibited the transcription of miR-142-5p by directly binding to the E-box fragment in the miR-142 promoter region. Furthermore, ZEB1 was negatively regulated by SRI which physically interacted with Smad4 to block its translocation from the cytosol to the nucleus. Taken together, our findings unveil a novel homeostatic loop of SRI that drives the PTX-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human OC. Targeting this SRI/Smad4/ZEB1/miR-142-5p loop may reverse the PTX-resistance.

scholarly journals Biological and Molecular Characteristics of Human Herpesvirus 7: In Vitro Growth Optimization and Development of a Syncytia Inhibition Test

Virology ◽  
1994 ◽  
Vol 202 (1) ◽  
pp. 506-512 ◽  
Author(s):  
Paola Secchiero ◽  
Zwi N. Berneman ◽  
Robert C. Gallo ◽  
Paolo Lusso
Keyword(s):  
Human Herpesvirus ◽  
Inhibition Test ◽  
Molecular Characteristics ◽  
In Vitro Growth ◽  
Growth Optimization

Quantitative cytochemical analysis by microdensitometry of spontaneous or α-MSH-stimulated melanogenesis in B16 melanoma cells cultivated in vitro

1985 ◽  
Vol 21 (8) ◽  
pp. 951-956 ◽  
Author(s):  
Marie-Claire A.J. de Pauw-Gillet ◽  
Jacques J. Hennet ◽  
Roger J.B. Bassleer
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells ◽  
Cytochemical Analysis

128 POSTER Vitamin E succinate inhibits the in vitro growth of pancreatic cancer cells

2006 ◽  
Vol 4 (12) ◽  
pp. 42
Author(s):  
D. Kumar ◽  
D. Patacsil ◽  
S. Osayi ◽  
P.C. Gokhale ◽  
M. Verma ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin E ◽  
Cancer Cells ◽  
In Vitro Growth ◽  
Vitamin E Succinate ◽  
Pancreatic Cancer Cells
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