HLA-DR/DQ Transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential

Biotherapy ◽  
1998 ◽  
Vol 10 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Annemieke Geluk ◽  
Veena Taneja ◽  
Krista E. van Meijgaarden ◽  
René R. P. de Vries ◽  
Chella S. David ◽  
...  
Keyword(s):  
T Cell ◽  
Class Ii ◽  
T Cell Epitopes ◽  
Hla Dr ◽  
Vaccine Potential ◽  
Novel Model ◽  
Deficient Mice ◽  
Preventative Vaccine

scholarly journals HLA-DR-Promiscuous T Cell Epitopes fromPlasmodiumfalciparumPre-Erythrocytic-Stage Antigens Restricted by Multiple HLA Class II Alleles

2000 ◽  
Vol 165 (2) ◽  
pp. 1123-1137 ◽  
Author(s):  
Denise L. Doolan ◽  
Scott Southwood ◽  
Robert Chesnut ◽  
Ettore Appella ◽  
Eduardo Gomez ◽  
...  
Keyword(s):  
T Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
T Cell Epitopes ◽  
Erythrocytic Stage ◽  
Hla Dr ◽  
Hla Class Ii Alleles

Overlapping T-cell epitopes in the group I allergen of species restricted by HLA-DP and HLA-DR class II molecules

1994 ◽  
Vol 93 (5) ◽  
pp. 891-899 ◽  
Author(s):  
J HIGGINS ◽  
C THORPE ◽  
J HAYBALL ◽  
R OHEHIR ◽  
J LAMB
Keyword(s):  
T Cell ◽  
Class Ii ◽  
T Cell Epitopes ◽  
Group I ◽  
Hla Dr

P018. A long peptide from MELOE-1 contains multiple HLA class II T cell epitopes in addition to the HLA-A*0201 epitope

2011 ◽  
Vol 21 ◽  
pp. e26-e27
Author(s):  
A. Rogel ◽  
V. Vignard ◽  
M. Bobinet ◽  
N. Labarrière ◽  
F. Lang
Keyword(s):  
T Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
T Cell Epitopes

Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1

2008 ◽  
Vol 57 (8) ◽  
pp. 1185-1195 ◽  
Author(s):  
Junko Matsuzaki ◽  
Feng Qian ◽  
Immanuel Luescher ◽  
Shashikant Lele ◽  
Gerd Ritter ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
Cd8 T Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
T Cell Epitopes ◽  
T Helper

scholarly journals Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells

2019 ◽  
Vol 8 (4) ◽  
pp. e1560919 ◽  
Author(s):  
Catherine Rabu ◽  
Laurie Rangan ◽  
Laetitia Florenceau ◽  
Agnès Fortun ◽  
Maud Charpentier ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cancer Vaccines ◽  
Class Ii ◽  
Class I ◽  
T Cell Epitopes ◽  
Synthetic Long Peptides

scholarly journals The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins

Virology ◽  
2010 ◽  
Vol 408 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Richard B. Kennedy ◽  
Gregory A. Poland
Keyword(s):  
T Cell ◽  
Membrane Proteins ◽  
Vaccinia Virus ◽  
Class Ii ◽  
Hla Class Ii ◽  
T Cell Epitopes

Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3

Vaccine ◽  
2009 ◽  
Vol 27 (34) ◽  
pp. 4718-4723 ◽  
Author(s):  
Matthias Piesche ◽  
York Hildebrandt ◽  
Björn Chapuy ◽  
Gerald G. Wulf ◽  
Lorenz Trümper ◽  
...  
Keyword(s):  
T Cell ◽  
Proteinase 3 ◽  
T Cell Epitopes ◽  
Hla Dr

scholarly journals Bordetella pertussis Proteins Dominating the Major Histocompatibility Complex Class II-Presented Epitope Repertoire in Human Monocyte-Derived Dendritic Cells

2014 ◽  
Vol 21 (5) ◽  
pp. 641-650 ◽  
Author(s):  
Rachel M. Stenger ◽  
Hugo D. Meiring ◽  
Betsy Kuipers ◽  
Martien Poelen ◽  
Jacqueline A. M. van Gaans-van den Brink ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
T Cell ◽  
Bordetella Pertussis ◽  
Human Monocyte ◽  
Class Ii ◽  
T Cell Epitopes ◽  
Major Histocompatibility ◽  
Content Type ◽  
Histocompatibility Complex

ABSTRACTKnowledge of naturally processedBordetella pertussis-specific T cell epitopes may help to increase our understanding of the basis of cell-mediated immune mechanisms to control this reemerging pathogen. Here, we elucidate for the first time the dominant major histocompatibility complex (MHC) class II-presentedB. pertussisCD4+T cell epitopes, expressed on human monocyte-derived dendritic cells (MDDC) after the processing of whole bacterial cells by use of a platform of immunoproteomics technology. Pertussis epitopes identified in the context of HLA-DR molecules were derived from two envelope proteins, i.e., putative periplasmic protein (PPP) and putative peptidoglycan-associated lipoprotein (PAL), and from two cytosolic proteins, i.e., 10-kDa chaperonin groES protein (groES) and adenylosuccinate synthetase (ASS). No epitopes were detectable from known virulence factors. CD4+T cell responsiveness in healthy adults against peptide pools representing epitope regions or full proteins confirmed the immunogenicity of PAL, PPP, groES, and ASS. Elevated lymphoproliferative activity to PPP, groES, and ASS in subjects within a year after the diagnosis of symptomatic pertussis suggested immunogenic exposure to these proteins during clinical infection. The PAL-, PPP-, groES-, and ASS-specific responses were associated with secretion of functional Th1 (tumor necrosis factor alpha [TNF-α] and gamma interferon [IFN-γ]) and Th2 (interleukin 5 [IL-5] and IL-13) cytokines. Relative paucity in the naturalB. pertussisepitope display of MDDC, not dominated by epitopes from known protective antigens, can interfere with the effectiveness of immune recognition ofB. pertussis. A more complete understanding of hallmarks inB. pertussis-specific immunity may advance the design of novel immunological assays and prevention strategies.

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

1994 ◽  
Vol 24 (9) ◽  
pp. 2213-2218 ◽  
Author(s):  
Amin Rahemtulla ◽  
Thomas M. Kündig ◽  
Arumugabadiv Narendran ◽  
Martin F. Bachmann ◽  
Michael Julius ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Cell Function ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
T Cell Function ◽  
Deficient Mice

Predicting promiscuous antigenic T cell epitopes of Mycobacterium tuberculosis mymA operon proteins binding to MHC Class I and Class II molecules

2016 ◽  
Vol 44 ◽  
pp. 182-189 ◽  
Author(s):  
Iti Saraav ◽  
Kirti Pandey ◽  
Monika Sharma ◽  
Swati Singh ◽  
Prasun Dutta ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Mhc Class I ◽  
Class Ii ◽  
Class I ◽  
T Cell Epitopes
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