Retrospective glycemic status of diabetic patients: Glycosylation of blood proteins in diabetes and chronic renal failure

1987 ◽  
Vol 24 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Kshama Kumari ◽  
V. Bansal ◽  
Jagmohan ◽  
C. G. Agarwal ◽  
Anil K. Rastogi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Diabetic Patients ◽  
Blood Proteins ◽  
Glycemic Status

Lipoprotein(a) in Diabetic Patients with and Without Chronic Renal Failure

Diabetes Care ◽  
1992 ◽  
Vol 15 (8) ◽  
pp. 976-979 ◽  
Author(s):  
P. J. Guillausseau ◽  
J. Peynet ◽  
P. Chanson ◽  
A. Legrand ◽  
J. J. Altman ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Diabetic Patients ◽  
Lipoprotein A

Correction formula for carbamylated haemoglobin in diabetic uraemic patients

2001 ◽  
Vol 38 (2) ◽  
pp. 115-119 ◽  
Author(s):  
A M A Hammouda ◽  
G E Mady
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Free Amino ◽  
Urea Concentration ◽  
Diabetic Patients ◽  
Amino Groups ◽  
Correction Formula ◽  
Significant Difference ◽  
And Control

The measurement of carbamylated haemoglobin is a useful indicator of uraemic state during the preceding few weeks in patients with renal failure. In diabetic uraemic patients with hyperglycaemia, glycation of haemoglobin may interfere with its carbamylation, as both reactions involve the free amino groups of the protein. The aim of this study was to investigate the carbamylation of haemoglobin in the presence of hyperglycaemia. The study included 29 patients with chronic renal failure on regular haemodialysis, 14 diabetic and 15 non-diabetic patients, and 10 healthy controls. We found a significant correlation between the degree of haemoglobin carbamylation and mean blood urea concentration in both uraemic and control subjects. Carbamylation of haemoglobin was higher in both diabetic and non-diabetic chronic renal failure patients, but there were no significant differences between the groups regarding mean blood urea concentration or level of haemoglobin carbamylation. Carbamylated haemoglobin per unit of blood urea concentration was lower in the diabetic patients. Using a correction formula to account for the degree of haemoglobin glycation, there was no longer a significant difference in carbamylation per unit of blood urea concentration. In vitro incubation of red blood cells from six healthy and six diabetic non-uraemic patients in 70mmol/L urea showed a significantly lower carbamylation in the diabetic patients, but there was no significant difference when using corrected carbamylated haemoglobin values. We conclude that glycation of haemoglobin affects its carbamylation and that monitoring of uraemia in a diabetic patient necessitates the use of carbamylated haemoglobin value corrected for the degree of glycation.

ANALYSIS OF THE ROLE OF MTHFR C677T AND TGF-BETA C-509T POLYMORPHISMS IN TYPE 1 DIABETIC PATIENTS WITH CHRONIC RENAL FAILURE

2008 ◽  
Vol 9 (1) ◽  
pp. 109
Author(s):  
C.I. Tecuceanu ◽  
D. Cimponeriu ◽  
P. Apostol ◽  
M. Stavarachi ◽  
M. Toma ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Mthfr C677t ◽  
Diabetic Patients ◽  
Tgf Beta ◽  
Type 1 Diabetic Patients

scholarly journals EFFECT OF HEMODIALYSIS ON MACULAR THICKENSS IN PATIENTS OF CHRONIC RENAL FAILURE WITH DIABETIC MACULAR EDEMA

2020 ◽  
pp. 1-3
Author(s):  
Kinjal Trivedi ◽  
Charmi Madhani ◽  
Saumil Parikh ◽  
Somesh Aggarwal
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Linear Regression Analysis ◽  
Macular Thickness ◽  
Serum Osmolality ◽  
P Value ◽  
Diabetic Patients ◽  
Before And After

Introduction: End stage renal disease (ESRD) patients undergoing hemodialysis (HD) have higher incidence of diabetic retinopathy (DR) and diabetic macular edema. Optical coherence tomography (OCT) which both diagnoses and quantifies degree of macular edema is gold standard for evaluating macular thickness. Materials and methods: We studied 30 patients, with DR who were treated with hemodialysis for ESRD. All patients underwent OCT examination 30 minutes before and after a hemodialysis session. Blood pressure (BP), weight, serum osmolality, glycemic hemoglobin and albumin levels were measured before and after hemodialysis. Student’s t-test and linear regression analysis test were used to analyze data. SPSS version 21.0 system was used for all statistical analyses and p value <0.05 was accepted as statistically significant. Results: In our study, BCVA failed to change significantly after the HD. Central and average macular thickness decreased by 3.49% and 1.61% respectively, both were statistically significant. Changes in maximum, central and average macular thickness, as well as in total macular volume were found to be significantly affected by changes in serum osmolality (p=0.04, 0.002, 0.02 and 0.03, respectively).We found no significant changes in maximum/average macular thickness with changes in total body weight or in mean arterial pressure after HD. Conclusion: Hemodialysis significantly decreases maximum macular thickness assessed by OCT in chronic renal failure diabetic patients with macular edema with no change in BCVA. Osmolality changes after hemodialysis were significantly associated with macular thickness.

scholarly journals Can Renal Replacement Be Deferred by a Supplemented Very Low Protein Diet?

1999 ◽  
Vol 10 (1) ◽  
pp. 110-116
Author(s):  
MACKENZIE WALSER ◽  
SYLVIA HILL
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Diabetic Patients ◽  
Renal Survival ◽  
Low Protein ◽  
Very Low Protein Diet

Abstract. Patients with chronic renal failure are commonly started on renal replacement therapy (RRT) as soon as (or, in some centers, before) the usual criteria for severity are met,i.e., GFR <10 ml/min for nondiabetic patients and <15 ml/min for diabetic patients. To determine whether RRT can safely be deferred beyond this point, adults with all types of chronic renal failure who met these criteria on presentation (23 patients) or who reached these levels of severity during treatment (53 patients) were managed conservatively until RRT was judged necessary by their chosen dialysis or transplantation team, without input into this decision from the present authors. Patients were prescribed a very low protein diet (0.3 g/kg) plus supplemental essential amino acids and/or ketoacids and followed closely. The intervals between the time at which GFR became less than 10 ml/min (15 ml/min in diabetic patients) and the date at which renal replacement therapy was started were used as estimates of renal survival on nutritional therapy. Kaplan—Meier analysis showed median renal survival of 353 d. Acidosis and hypercholesterolemia were both predictive of shorter renal survival. Signs of malnutrition did not develop. Final GFR averaged 5.6 ± 1.9 ml/min. Two patients died; thus, annual mortality was only 2.5%. Hospitalizations totaled 19 in 93 patient-years of treatment, or 0.2 per year. Thus, these well motivated patients with GFR <10 ml/min (<15 ml/min in diabetic patients) were safely managed by diet and close follow-up for a median of nearly 1 yr without dialysis. It is concluded that further study of this approach is indicated.

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