Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride

2006 ◽  
Vol 23 (5) ◽  
pp. 663-671 ◽  
Author(s):  
Jess T. Whitson ◽  
H. Dwight Cavanagh ◽  
Neema Lakshman ◽  
W. Matthew Petroll
Keyword(s):  
Benzalkonium Chloride ◽  
Acute Exposure ◽  
Epithelial Integrity ◽  
Corneal Epithelial

Benzalkonium Chloride-Induced Corneal Epithelial Injury in Rabbit Reduced by Rebamipide

2021 ◽  
Author(s):  
Masamichi Fukuda ◽  
Nobuo Takeda ◽  
Hidetoshi Ishida ◽  
Yusuke Seki ◽  
Naoko Shibata ◽  
...  
Keyword(s):  
Benzalkonium Chloride ◽  
Epithelial Injury ◽  
Corneal Epithelial

scholarly journals Cytoprotective effect of amniotic membrane extracts on human corneal epithelial cells exposed to benzalkonium chloride in vitro

2020 ◽  
Vol 5 ◽  
pp. 11-11
Author(s):  
Jiayan Liu ◽  
Huyong Zou ◽  
Minzhi Zeng ◽  
Amy Michelle Huang ◽  
Yan Chen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Amniotic Membrane ◽  
Benzalkonium Chloride ◽  
Cytoprotective Effect ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells

Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing

2019 ◽  
Vol 39 (1) ◽  
pp. 13-20
Author(s):  
Satoshi Seino ◽  
Ryosuke Matsuoka ◽  
Yasunobu Masuda ◽  
Masaaki Kunou ◽  
Yuka Okada ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Epithelial Cell ◽  
Benzalkonium Chloride ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Cell Migration ◽  
Epithelial Wound Healing

scholarly journals Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Naoto Tokuda ◽  
Yasushi Kitaoka ◽  
Akiko Matsuzawa ◽  
Ayaka Tsukamoto ◽  
Kana Sase ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Barrier Function ◽  
Benzalkonium Chloride ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Surface Characteristics ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial ◽  
Preservative Free

Purpose. The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. Materials and Methods. Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes). The intraocular pressure, corneal epithelial barrier function (fluorescein uptake concentration with fluorophotometer FL-500), superficial punctate keratopathy (AD classification), and tear film breakup time (TBUT) were assessed before switching and at 12 weeks after switching. Results. No significant differences in intraocular pressure were noted after switching in either group. Corneal epithelial barrier function was improved significantly after switching in both the Tafluprost-containing-preservative and the preservative-free-Tafluprost groups. There were no significant differences in AD scores after switching in the Tafluprost-containing-preservative group, but significant improvements were noted in the preservative-free-Tafluprost group. No significant differences in TBUT were noted in the Tafluprost-containing-preservative or preservative-free-Tafluprost groups after switching. Conclusion. After switching from preservative Latanoprost to Tafluprost containing-preservative or preservative-free Tafluprost, corneal epithelial barrier function was improved while the intraocular pressure reduction was retained.

Benzalkonium Chloride Induces Dephosphorylation of Myosin Light Chain in Cultured Corneal Epithelial Cells

2007 ◽  
Vol 48 (5) ◽  
pp. 2001 ◽  
Author(s):  
Ying Guo ◽  
Minati Satpathy ◽  
Graeme Wilson ◽  
Sangly P. Srinivas
Keyword(s):  
Epithelial Cells ◽  
Light Chain ◽  
Benzalkonium Chloride ◽  
Myosin Light Chain ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial

scholarly journals Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

2021 ◽  
Vol 62 (2) ◽  
pp. 38
Author(s):  
Kirthana Senthil ◽  
Haihan Jiao ◽  
Laura E. Downie ◽  
Holly R. Chinnery
Keyword(s):  
Dendritic Cell ◽  
Cell Morphology ◽  
Acute Exposure ◽  
Corneal Epithelial

Corneal Epithelial Wound Healing After Treatment with Gatifloxacin with or Without Benzalkonium Chloride in Rabbits

2008 ◽  
Vol 49 (6) ◽  
pp. 987
Author(s):  
Hyung Bin Hwang ◽  
Chang Rae Roh ◽  
Sung Kun Chung
Keyword(s):  
Wound Healing ◽  
Benzalkonium Chloride ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

The Effect of Resveratrol on Protecting Corneal Epithelial Cells from Cytotoxicity Caused by Moxifloxacin and Benzalkonium Chloride

2015 ◽  
Vol 56 (3) ◽  
pp. 1575-1584 ◽  
Author(s):  
T.-Y. Tsai ◽  
T.-C. Chen ◽  
I.-J. Wang ◽  
C.-Y. Yeh ◽  
M.-J. Su ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Benzalkonium Chloride ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial

scholarly journals Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Erkut Küçük ◽  
Uğur Yılmaz ◽  
Kürsad Ramazan Zor
Keyword(s):  
Matched Control ◽  
Tear Film ◽  
Control Group ◽  
Healthy Controls ◽  
Epithelial Defect ◽  
Epithelial Integrity ◽  
Corneal Epithelial ◽  
Matched Control Group ◽  
Age And Sex ◽  
Fellow Eyes

Purpose. In this study, we evaluated corneal epithelial integrity and tear film parameters in patients with inflamed pinguecula and compared these findings with their fellow eyes and with healthy controls. Methods. We evaluated the fluorescein staining properties and performed the tear break-up time (TBUT) test and Schirmer 2 test (ST2) measurements of 32 patients who had symptomatic unilateral inflamed pinguecula and compared the results with their fellow eyes and also with an age- and sex-matched control group. Results. Twenty-three eyes (72%) in the inflamed pinguecula group and 1 eye (3.1%) in the fellow eyes group had punctate epithelial staining (PES) or epithelial defect on the nasal cornea (p<0.001). There was no PES or epithelial defect in the control group. Eyes with inflamed pinguecula (n = 32) had lower TBUT and ST2 values compared to the control group (n = 32) (p<0.001 for both). Fellow eyes (n = 32) also had lower TBUT and ST2 values compared to the control group (p=0.003 for both). There was no difference in the TBUT and ST2 results between the eyes with inflamed pinguecula and fellow eyes (p=0.286 and p=0.951, respectively). Conclusion. A high percentage of eyes with inflamed pinguecula had nasal corneal epithelial staining or epithelial defect. We also found lower TBUT and ST2 results in eyes with inflamed pinguecula and the fellow eyes compared to the control group. These findings may be important in pathogenesis of pinguecula and pterygium and also in uncovering their relation.

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