Metabolic control and growth regulation in the regenerating human liver measured in vivo by 31-phosophorus magnetic resonance spectroscopy

2002 ◽  
Vol 1 (3) ◽  
pp. 152-155
Author(s):  
Mann D. V. ◽  
Lau W. Y.
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Metabolic Control ◽  
Human Liver ◽  
Growth Regulation ◽  
Resonance Spectroscopy

scholarly journals Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

2021 ◽  
Author(s):  
John G. Jones
Keyword(s):  
Magnetic Resonance ◽  
Stable Isotope ◽  
Magnetic Resonance Spectroscopy ◽  
Human Liver ◽  
Liver Metabolism ◽  
Resonance Spectroscopy ◽  
Stable Isotope Tracers ◽  
Isotope Tracers ◽  
Non Invasive

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.

scholarly journals Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 751
Author(s):  
John G. Jones
Keyword(s):  
Magnetic Resonance ◽  
Stable Isotope ◽  
Magnetic Resonance Spectroscopy ◽  
Human Liver ◽  
Liver Metabolism ◽  
Resonance Spectroscopy ◽  
Stable Isotope Tracers ◽  
Isotope Tracers ◽  
Non Invasive

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.

Biological NMR Spectroscopy

1997 ◽  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
State Of The Art ◽  
Critical Assessment ◽  
Resonance Spectroscopy ◽  
History Of ◽  
Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

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