Determination of arterial wall shear stress

2001 ◽  
Vol 44 (10) ◽  
pp. 1312-1321 ◽  
Author(s):  
Zhaorong Liu ◽  
Feng He ◽  
Gang Xu ◽  
Yong Chen
2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Kap-Soo Han ◽  
Sang Hyuk Lee ◽  
Han Uk Ryu ◽  
Se-Hyoung Park ◽  
Gyung-Ho Chung ◽  
...  

The aim of the study was to calculate the arterial wall signal intensity gradient (SIG) from time-of-flight MR angiography (TOF-MRA) and represent arterial wall shear stress. We developed a new algorithm that uses signal intensity (SI) of a TOF-MRA to directly calculate the signal intensity gradient (SIG). The results from our phantom study showed that the TOF-MRA SIG could be used to distinguish the magnitude of blood flow rate as high (mean SIG ± SD, 2.2 ± 0.4 SI/mm for 12.5 ± 2.3 L/min) and low (0.9 ± 0.3 SI/mm for 8.5 ± 2.6 L/min) in vessels (p<0.001). Additionally, we found that the TOF-MRA SIG values were highly correlated with various flow rates (β=0.96, p<0.001). Remarkably, the correlation coefficient between the WSS obtained from the computational fluid dynamics (CFD) analysis and the TOF-MRA SIG was greater than 0.8 in each section at the carotid artery (p<0.001 for all β values). This new technique using TOF-MRA could enable the rapid calculation of the TOF-MRA SIG and thereby the WSS. Thus, the TOF-MRA SIG can provide clinicians with an accurate and efficient screening method for making rapid decisions on the risk of vascular disease for a patient in clinical practice.


2008 ◽  
Vol 294 (2) ◽  
pp. H909-H919 ◽  
Author(s):  
Ufuk Olgac ◽  
Vartan Kurtcuoglu ◽  
Dimos Poulikakos

The work herein represents a novel approach for the modeling of low-density lipoprotein (LDL) transport from the artery lumen into the arterial wall, taking into account the effects of local wall shear stress (WSS) on the endothelial cell layer and its pathways of volume and solute flux. We have simulated LDL transport in an axisymmetric representation of a stenosed coronary artery, where the endothelium is represented by a three-pore model that takes into account the contributions of the vesicular pathway, normal junctions, and leaky junctions also employing the local WSS to yield the overall volume and solute flux. The fraction of leaky junctions is calculated as a function of the local WSS based on published experimental data and is used in conjunction with the pore theory to determine the transport properties of this pathway. We have found elevated levels of solute flux at low shear stress regions because of the presence of a larger number of leaky junctions compared with high shear stress regions. Accordingly, we were able to observe high LDL concentrations in the arterial wall in these low shear stress regions despite increased filtration velocity, indicating that the increase in filtration velocity is not sufficient for the convective removal of LDL.


Author(s):  
Emna Berrich ◽  
Fethi Aloui ◽  
Jack Legrand

The inverse method, based on a numerical sequential estimation, has been applied for the determination of the wall shear stress of a liquid single phase flow in a sliding rheometer using multi-segment probe. This method requires the inversion of the convection diffusion equation in order to apply it to instantaneous mass transfer measurements. Polarography technique, known as the limiting diffusion current method, has been used. This requires the use of Electro-Diffusion ED probe which allows the determination of the local mass transfer rate for known flow kinematics. In addition, two-segment platinum probe was mounted flush to the inert surface of the upper disk of the sliding rheometer. Hydrodynamic oscillations have been imposed to the torsional flow (type sinusoidal), in order to study the frequency response of the sandwich probe for a fixed polarization voltage. Possible error sources which are likely to affect the interpretation of the results e.g. the directional angle effect, the inertial effect, the diffusion effect and the frequencies of oscillations effect have been studied in order to test the robustness of the inverse method within the presence of such impacts. Furthermore, to demonstrate the possible effect of non-negligible inertia and diffusion, we refer to ED results for both modified Reynolds number defined by [1] and Peclet number ranges as well as for different directional angles. An algorithm has been developed for the numerically filtering of the mass transfer signals, and therefore the wall shear stress signals. It permits to eliminate any possible noise effect due to the imposed vibrations to the torsional flow. The analysis shown that the inverse method is in a good agreement with the ED experimental results for the different cases of study, i.e. for different dimensionless Reynolds numbers, for high and low oscillation frequencies, as well as for different directional angles. The little difference is probably caused by the sensitivity of the double probe to such directional angles or to the neglecting of the insulating gap effect on the inverse method solution as a first step of the study of the inverse method for double probes signals.


2020 ◽  
Vol 10 ◽  
Author(s):  
Vivek P. Jani ◽  
Alfredo Lucas ◽  
Vinay P. Jani ◽  
Carlos Munoz ◽  
Alexander T. Williams ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document