An experimental study on the regulation of expression of Th2 cytokines from T lymphocytes by protein kinase C in asthma

2001 ◽  
Vol 21 (4) ◽  
pp. 292-296 ◽  
Author(s):  
Xiong Weining ◽  
Xu Yongjian ◽  
Zhang Zhenxiang ◽  
Wang Xiaoyang ◽  
Mo Biwen ◽  
...  
Keyword(s):  
Experimental Study ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Th2 Cytokines ◽  
Regulation Of Expression ◽  
Kinase C

Activation-dependent phosphorylation of endogeneous protein kinase c substrates in quiescent human T lymphocytes

Immunobiology ◽  
1988 ◽  
Vol 176 (4-5) ◽  
pp. 465-478 ◽  
Author(s):  
Bengt Friedrich ◽  
Kristina Noreus ◽  
Doreen A. Cantrell ◽  
Martin Gullberg
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Human T Lymphocytes ◽  
Kinase C

scholarly journals Heterogeneity of protein kinase C expression and regulation in T lymphocytes

FEBS Letters ◽  
1990 ◽  
Vol 260 (1) ◽  
pp. 53-56 ◽  
Author(s):  
S. Lucas ◽  
R. Marais ◽  
J.D. Graves ◽  
D. Alexandere ◽  
P. Parker ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Kinase C

scholarly journals Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes

2011 ◽  
Vol 41 (6) ◽  
pp. 704-719 ◽  
Author(s):  
Elissa L. Sutcliffe ◽  
Karen L. Bunting ◽  
Yi Qing He ◽  
Jasmine Li ◽  
Chansavath Phetsouphanh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Gene Expression Program ◽  
Inducible Gene Expression ◽  
Human T Lymphocytes ◽  
Kinase C ◽  
Expression Program ◽  
Inducible Gene

scholarly journals Mechanisms for Induction of L-Selectin Loss from T Lymphocytes by a Cryptococcal Polysaccharide, Glucuronoxylomannan

1999 ◽  
Vol 67 (1) ◽  
pp. 220-229 ◽  
Author(s):  
Zhao Ming Dong ◽  
Lydgia Jackson ◽  
Juneann W. Murphy
Keyword(s):  
T Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Tyrosine Kinases ◽  
Jurkat Cells ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Herbimycin A ◽  
Kinase C

ABSTRACT Disseminated cryptococcosis is accompanied by cryptococcal polysaccharides in the serum and the lack of cellular infiltrates in infected tissues. Cryptococcal polysaccharides given intravenously to mice inhibit the influx of T lymphocytes into the sites of cell-mediated immune response. The focus here was to determine whether cryptococcal polysaccharides modulate the expression of molecules, such as L-selectin, that are important in extravasation of T cells. Cryptococcal glucuronoxylomannan (GXM), but not galactoxylomannan or mannoprotein, was found to cause loss of L-selectin from freshly isolated human T cells of both CD4 and CD8 subsets and from Jurkat cells. With the signaling-pathway inhibitors staurosporine (which inhibits protein kinase C) and herbimycin A (which inhibits protein tyrosine kinases), we showed that GXM or the cryptococcal culture filtrate antigen CneF directly induces L-selectin loss from CD4+ and CD8+ T cells via a herbimycin A-sensitive pathway(s) presumably involving one or more protein tyrosine kinases but not via a pathway involving protein kinase C. Loss of L-selectin from the T cells before the T cells have a chance to bind to L-selectin ligands on endothelial cells would be expected to prevent T-cell migration into inflamed tissues and/or lymph organs.

Different early-signaling pathways coupled to transcriptional and posttranscriptional regulation of gene expression during mitogenic activation of T lymphocytes

1987 ◽  
Vol 7 (8) ◽  
pp. 3004-3007
Author(s):  
M W White ◽  
A K Oberhauser ◽  
C A Kuepfer ◽  
D R Morris
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Posttranscriptional Regulation ◽  
Regulation Of Gene Expression ◽  
Alpha Tubulin ◽  
Kinase C

Two categories of mitogen-induced mRNAs were defined in T lymphocytes. The type 1 messages (represented by c-myc) were regulated transcriptionally, and their expression seemed to be calmodulin dependent. The type 2 messages (ornithine decarboxylase, actin, and alpha-tubulin) were regulated posttranscriptionally through activation of protein kinase C.

scholarly journals Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia

2001 ◽  
Vol 123 (3) ◽  
pp. 472-480 ◽  
Author(s):  
M. A. García-Pérez ◽  
L. M. Allende ◽  
A. Corell ◽  
P. Varela ◽  
A. A. Moreno ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Ataxia Telangiectasia ◽  
Novel Mutations ◽  
Kinase C ◽  
Protein Kinase C Activation

The role of protein kinase C in early activation vs. growth of T lymphocytes

1988 ◽  
Vol 18 (3) ◽  
pp. 489-492 ◽  
Author(s):  
Bengt Friedrich ◽  
Martin Gullberg
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Kinase C ◽  
Early Activation
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