The role of CD4+ tumor-infiltrating lymphocytes in human solid tumors

1995 ◽  
Vol 14 (2) ◽  
pp. 119-131 ◽  
Author(s):  
Peter S. Goedegebuure ◽  
Timothy J. Eberlein
Keyword(s):  
Solid Tumors ◽  
Tumor Infiltrating Lymphocytes ◽  
Human Solid Tumors ◽  
Infiltrating Lymphocytes

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

2019 ◽  
Vol 343 ◽  
pp. 103753 ◽  
Author(s):  
Giuseppe Badalamenti ◽  
Daniele Fanale ◽  
Lorena Incorvaia ◽  
Nadia Barraco ◽  
Angela Listì ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors

1986 ◽  
Vol 90 (2) ◽  
pp. 221-233 ◽  
Author(s):  
Theresa L. Whiteside ◽  
Sylvia Miescher ◽  
H.R. MacDonald ◽  
V. Von Fliedner
Keyword(s):  
Solid Tumors ◽  
Tumor Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Human Solid Tumors ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic Role of Tumor‐Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma

2021 ◽  
Author(s):  
Yukiko Hori ◽  
Akira Kubota ◽  
Tomoyuki Yokose ◽  
Madoka Furukawa ◽  
Takeshi Matsushita ◽  
...  
Keyword(s):  
Tumor Infiltrating Lymphocytes ◽  
Tumor Budding ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Immunity and cancer: role of tumor-infiltrating lymphocytes in triple-negative breast cancer

2021 ◽  
Vol 49 (1) ◽  
pp. 20-28
Author(s):  
Ana Tečić-Vuger ◽  
◽  
Robert Šeparović ◽  
Ljubica Vazdar ◽  
Mirjana Pavlović ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals The Immune Response to Tumors as a Tool toward Immunotherapy

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
F. Pandolfi ◽  
R. Cianci ◽  
D. Pagliari ◽  
F. Casciano ◽  
C. Bagalà ◽  
...  
Keyword(s):  
Immune Response ◽  
Monoclonal Antibodies ◽  
Cancer Colorectal ◽  
Immune Cell ◽  
Cytotoxic T Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Hematologic Malignancies ◽  
The Novel ◽  
Infiltrating Lymphocytes

Until recently cancer medical therapy was limited to chemotherapy that could not differentiate cancer cells from normal cells. More recently with the remarkable mushroom of immunology, newer tools became available, resulting in the novel possibility to attack cancer with the specificity of the immune system. Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies. Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors. This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs. Immunotherapy may also use cytokines especially proinflammatory cytokines to enhance the activity of cytotoxic T cells (CTLs) derived from tumor infiltrating lymphocytes (TILs). The role of newly discovered cytokines remains to be investigated. Alternatively, an other mechanism consists in enhancing the expression of TAAs on tumor cells. Finally, monoclonal antibodies may be used to target oncogenes.

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