Enhanced antitumor effects of suicide gene therapy by simultaneous transfer of GM-CSF gene in leukemia-bearing mice

1998 ◽  
Vol 10 (2) ◽  
pp. 79-83
Author(s):  
Dianwen Ju ◽  
Xuetao Cao ◽  
Yizhi Yu ◽  
Qun Tao ◽  
Baomei Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Gm Csf ◽  
Simultaneous Transfer

scholarly journals miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy

2008 ◽  
Vol 16 (10) ◽  
pp. 1719-1726 ◽  
Author(s):  
Takayuki Suzuki ◽  
Fuminori Sakurai ◽  
Shin-ichiro Nakamura ◽  
Emi Kouyama ◽  
Kenji Kawabata ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Regulated Expression

scholarly journals Connexin32-mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity

2016 ◽  
Vol 13 (4) ◽  
pp. 3213-3219 ◽  
Author(s):  
LUN WU ◽  
WEN-BO ZHOU ◽  
FENG SHEN ◽  
WEI LIU ◽  
HONG-WEI WU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Anticancer Activity ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects

Co-expression of interleukin 12 enhances antitumor effects of a novel chimeric promoter-mediated suicide gene therapy in an immunocompetent mouse model

2011 ◽  
Vol 412 (4) ◽  
pp. 763-768 ◽  
Author(s):  
Yu Xu ◽  
Zhengchun Liu ◽  
Haiyan Kong ◽  
Wenjie Sun ◽  
Zhengkai Liao ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Interleukin 12 ◽  
Immunocompetent Mouse ◽  
Antitumor Effects ◽  
Chimeric Promoter

scholarly journals Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma

2006 ◽  
Vol 178 (1) ◽  
pp. 574-583 ◽  
Author(s):  
Tomoya Tsuchiyama ◽  
Yasunari Nakamoto ◽  
Yoshio Sakai ◽  
Yohei Marukawa ◽  
Masaaki Kitahara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Nk Cell ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Effect of GM-CSF on tumor-specific immune response and antitumoral efficacy when combined with suicide gene therapy

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e14610-e14610
Author(s):  
H. Akbulut ◽  
A. Coleri ◽  
N. Acikgoz ◽  
G. Sahin ◽  
P. Ozkal ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Colon Cancer ◽  
Immune Response ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Specific Immune Response ◽  
Gm Csf ◽  
Syngeneic Mouse Model ◽  
Tumor Specific Immune Response

e14610 Background: Suicide gene therapy is one of the promising treatment modalities in cancer treatment. Combination of an immunotherapy modality with suicide gene therapy would increase the tumor eradciating efficacy of either treatment strategy used alone. Methods: In the current study, we constructed adenoviral vectors carying ytosine deaminase (CD), granulocyte macrophage-colony stimulating factor (GM-CSF) vectors. We tested the in vitro efficacy of the vectors in both human and mouse tumor cell lines and in a syngeneic mouse model of colon cancer with tumor explants of CRL 2638 cells. Results: Our results show that the vectors carrying CD/GM-CSF transcription units are effective in terms of killing of tumor cells when 5-FC added. Addition of GM-CSF transgene induced a significant amount of GM-CSF secretion (250 pg/ml/105 cells) of infected cells. In the syngeneic colon cancer model, addition of GM-CSF significantly increased tumor-specific cellular immune response when compared to suicide gene therapy alone. (p<0.01). Likewise, GM-CSF addition caused a 8 times reduction in the ratio of Tregs infiltrating the tumor nodules (p<0.001). Accordingly, GM-CSF decreased the tumor growth by 2 times an d increased the median survival time by 50% (p<0.01). Conclusions: These impressive results of in-vitro cytotoxicity and encouraging results of in-vivo testing of the our newly constructed GM-CSF carrying vector suggest a potential for the use of the vector for the treament of established tumors by inducing tumor specific immune response. No significant financial relationships to disclose.

scholarly journals Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

Gene Therapy ◽  
2000 ◽  
Vol 7 (19) ◽  
pp. 1672-1679 ◽  
Author(s):  
D W Ju ◽  
Y Yang ◽  
Q Tao ◽  
W G Song ◽  
L He ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Antitumor Immunity ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Interleukin 18 ◽  
Antitumor Effects ◽  
Efficient Induction

An AutologousIn SituTumor Vaccination Approach for Hepatocellular Carcinoma. 1. Flt3 Ligand Gene Transfer Increases Antitumor Effects of a Radio-Inducible Suicide Gene Therapy in an Ectopic Tumor Model

2014 ◽  
Vol 182 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Yujo Kawashita ◽  
Niloy J. Deb ◽  
Madhur Garg ◽  
Rafi Kabarriti ◽  
Alan Alfieri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Gene Transfer ◽  
Tumor Model ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Flt3 Ligand ◽  
Antitumor Effects

Cyclooxygenese-2 promoter can mittigate the lethal toxicity in HSV-TK based adenoviral suicide gene therapy of gastrointestinal cancers

2001 ◽  
Vol 120 (5) ◽  
pp. A10-A10
Author(s):  
M YAMAMOTO ◽  
R ALEMANY ◽  
Y ADACHI ◽  
W GRIZZLE ◽  
D CURIEL
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers ◽  
Lethal Toxicity

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

2020 ◽  
Vol 3 (8) ◽  
pp. 2000007
Author(s):  
Lucia Salvioni ◽  
Stefania Zuppone ◽  
Francesco Andreata ◽  
Matteo Monieri ◽  
Serena Mazzucchelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suicide Gene ◽  
Breast Cancer Treatment ◽  
Suicide Gene Therapy
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