scholarly journals miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy

2008 ◽  
Vol 16 (10) ◽  
pp. 1719-1726 ◽  
Author(s):  
Takayuki Suzuki ◽  
Fuminori Sakurai ◽  
Shin-ichiro Nakamura ◽  
Emi Kouyama ◽  
Kenji Kawabata ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Regulated Expression

scholarly journals Connexin32-mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity

2016 ◽  
Vol 13 (4) ◽  
pp. 3213-3219 ◽  
Author(s):  
LUN WU ◽  
WEN-BO ZHOU ◽  
FENG SHEN ◽  
WEI LIU ◽  
HONG-WEI WU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Anticancer Activity ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects

Co-expression of interleukin 12 enhances antitumor effects of a novel chimeric promoter-mediated suicide gene therapy in an immunocompetent mouse model

2011 ◽  
Vol 412 (4) ◽  
pp. 763-768 ◽  
Author(s):  
Yu Xu ◽  
Zhengchun Liu ◽  
Haiyan Kong ◽  
Wenjie Sun ◽  
Zhengkai Liao ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Interleukin 12 ◽  
Immunocompetent Mouse ◽  
Antitumor Effects ◽  
Chimeric Promoter

scholarly journals Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma

2006 ◽  
Vol 178 (1) ◽  
pp. 574-583 ◽  
Author(s):  
Tomoya Tsuchiyama ◽  
Yasunari Nakamoto ◽  
Yoshio Sakai ◽  
Yohei Marukawa ◽  
Masaaki Kitahara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Nk Cell ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

Gene Therapy ◽  
2000 ◽  
Vol 7 (19) ◽  
pp. 1672-1679 ◽  
Author(s):  
D W Ju ◽  
Y Yang ◽  
Q Tao ◽  
W G Song ◽  
L He ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Antitumor Immunity ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Interleukin 18 ◽  
Antitumor Effects ◽  
Efficient Induction

An AutologousIn SituTumor Vaccination Approach for Hepatocellular Carcinoma. 1. Flt3 Ligand Gene Transfer Increases Antitumor Effects of a Radio-Inducible Suicide Gene Therapy in an Ectopic Tumor Model

2014 ◽  
Vol 182 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Yujo Kawashita ◽  
Niloy J. Deb ◽  
Madhur Garg ◽  
Rafi Kabarriti ◽  
Alan Alfieri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Gene Transfer ◽  
Tumor Model ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Flt3 Ligand ◽  
Antitumor Effects

Enhanced antitumor effects of suicide gene therapy by simultaneous transfer of GM-CSF gene in leukemia-bearing mice

1998 ◽  
Vol 10 (2) ◽  
pp. 79-83
Author(s):  
Dianwen Ju ◽  
Xuetao Cao ◽  
Yizhi Yu ◽  
Qun Tao ◽  
Baomei Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Antitumor Effects ◽  
Gm Csf ◽  
Simultaneous Transfer

Cyclooxygenese-2 promoter can mittigate the lethal toxicity in HSV-TK based adenoviral suicide gene therapy of gastrointestinal cancers

2001 ◽  
Vol 120 (5) ◽  
pp. A10-A10
Author(s):  
M YAMAMOTO ◽  
R ALEMANY ◽  
Y ADACHI ◽  
W GRIZZLE ◽  
D CURIEL
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Gastrointestinal Cancers ◽  
Lethal Toxicity

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

2020 ◽  
Vol 3 (8) ◽  
pp. 2000007
Author(s):  
Lucia Salvioni ◽  
Stefania Zuppone ◽  
Francesco Andreata ◽  
Matteo Monieri ◽  
Serena Mazzucchelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suicide Gene ◽  
Breast Cancer Treatment ◽  
Suicide Gene Therapy

scholarly journals Development of iRGD-Modified Peptide Carriers for Suicide Gene Therapy of Uterine Leiomyoma

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 202
Author(s):  
Anna Egorova ◽  
Sofia Shtykalova ◽  
Alexander Selutin ◽  
Natalia Shved ◽  
Marianna Maretina ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Uterine Leiomyoma ◽  
Transfection Efficiency ◽  
Chemical Properties ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Benign Tumors ◽  
Αvβ3 Integrin ◽  
Peptide Carrier ◽  
Plasmid Delivery

Uterine leiomyoma (UL) is one of the most common benign tumors in women that often leads to many reproductive complications. Suicide genetherapy was suggested as a promising approach for UL treatment. In the present study, we describe iRGD ligand-conjugated cysteine-rich peptide carrier RGD1-R6 for targeted DNA delivery to αvβ3 integrin-expressing primary UL cells. The physico-chemical properties, cytotoxicity, transfection efficiency and specificity of DNA/RGD1-R6 polyplexes were investigated. TheHSV-1thymidine kinase encoding plasmid delivery to PANC-1pancreatic carcinoma cells and primary UL cells resulted in significant suicide gene therapy effects. Subsequent ganciclovir treatment decreased cells proliferative activity, induced of apoptosis and promoted cells death.The obtained results allow us to concludethatthe developed RGD1-R6 carrier can be considered a promising candidate for suicide gene therapy of uterine leiomyoma.

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