The inhibitory effect of extract of camellia sinensis and extract of Camellia Ptilophylla Chang on dna polymerase of ehrlich ascites carcinoma cells

1998 ◽  
Vol 10 (4) ◽  
pp. 251-255 ◽  
Author(s):  
Lijian Xian ◽  
Zongchao Liu ◽  
Qichao Pan ◽  
Hanxi Li
Keyword(s):  
Dna Polymerase ◽  
Camellia Sinensis ◽  
Ehrlich Ascites Carcinoma ◽  
Inhibitory Effect ◽  
Carcinoma Cells ◽  
Ehrlich Ascites

THE OXIDATION OF LEUCINE BY EHRLICH ASCITES CARCINOMA CELLS

1965 ◽  
Vol 43 (7) ◽  
pp. 977-991 ◽  
Author(s):  
P. G. Scholefield
Keyword(s):  
Fatty Acids ◽  
Mouse Liver ◽  
Ehrlich Ascites Carcinoma ◽  
Inhibitory Effect ◽  
Carcinoma Cells ◽  
Effective Inhibitor ◽  
Leucine Oxidation ◽  
Liver Slices ◽  
Ehrlich Ascites ◽  
Keto Acids

The oxidation of leucine-1-14C to14CO2by Ehrlich ascites carcinoma cells was inhibited on addition of pyruvate and other α-keto acids, a maximum inhibitory effect being attained with 1 mM pyruvate. The only compound, among those tested, which reversed this inhibition was malonate. Oxidation of leucine-2-14C to14CO2occurred at a rate which was 1% of that observed with leucine-1-14C and was sensitive to the presence of fatty acids as well as to pyruvate. Glutamine was a particularly effective inhibitor of leucine oxidation. The inhibition produced by isoleucine was competitive, the KIvalue being 0.13 mM compared with the KMvalue of 0.2 mM. It is suggested that the inhibition by pyruvate is due to a competition between pyruvate and the α-ketoisovaleric acid derived from leucine for the cofactors required for the oxidation of the α-keto acids. In contrast, oxidation of leucine-1-14C by mouse liver slices was increased approximately threefold by pyruvate.

scholarly journals Inhibitory effect of cyclophosphamide on the biosynthesis of a perchloro-soluble protein fraction of ehrlich ascites carcinoma cells

1973 ◽  
Vol 71 (4) ◽  
pp. 439-442
Author(s):  
R. Raposo Abreu ◽  
Luiz A. Abreu
Keyword(s):  
Soluble Protein ◽  
Protein Fraction ◽  
Ehrlich Ascites Carcinoma ◽  
Inhibitory Effect ◽  
Carcinoma Cells ◽  
Post Inoculation ◽  
Soluble Protein Fraction ◽  
Single Subcutaneous Dose ◽  
Subcutaneous Dose ◽  
Ehrlich Ascites

The perchloro-soluble mucroptotein fraction was determined in the cells of Ehrlich ascites carcinoma on the 10th and 12th days post-inoculation of the tumor. After 3 days of a single subcutaneous dose of cyclophosphamide (200 mg/kg) the mucoprotein levels were found considerable lower. This difference was highly significant statistically.

Trichosanthes dioica seed lectin inhibits Ehrlich ascites carcinoma cells growth in vivo in mice by inducing G 0 /G 1 cell cycle arrest

2021 ◽  
Author(s):  
Shaikh Shohidul Islam ◽  
Md. Rezaul Karim ◽  
A. K. M. Asaduzzaman ◽  
A. H. M. Khurshid Alam ◽  
Zahid Hayat Mahmud ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Ehrlich Ascites ◽  
Trichosanthes Dioica

STUDIES ON THE BIOSYNTHESIS OF NUCLEOTIDES IN EHRLICH ASCITES CARCINOMA CELLS IN VITRO

1965 ◽  
Vol 43 (2) ◽  
pp. 209-224 ◽  
Author(s):  
B. I. Uppin ◽  
P. G. Scholefield
Keyword(s):  
Exchange Reaction ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
The Other ◽  
Metabolic Inhibitors ◽  
Ehrlich Ascites ◽  
Oxidative Pathway ◽  
Time Courses ◽  
Oxidation Of Glucose

Studies have been made of the effects of metabolic inhibitors on the oxidation and incorporation of radioactivity into nucleotides of glucose labelled in the 1, 2, and 6 positions. The results indicate that in Ehrlich ascites carcinoma cells the predominant oxidative pathway is the hexosemonophosphate shunt. Investigation of the time courses of oxidation of the labelled glucose molecules confirms this conclusion. The pattern of incorporation of radioactivity initially suggests that nucleotide ribose is not formed via this pathway. However, it is shown that the coupling of an active transketolase system with the other enzymes of the hexosemonophosphate shunt provides a sufficient explanation of all the experimental observations. The conclusion is reached that pentose is formed by oxidation of glucose through the shunt but that the labelling pattern is largely established as the result of the exchange reaction catalyzed by transketolase.

Synergistic Killing of Ehrlich Ascites Carcinoma Cells by Ascorbate and 3-Amino-1,2,4,-triazole

Oncology ◽  
1969 ◽  
Vol 23 (1) ◽  
pp. 33-43 ◽  
Author(s):  
L. Benade ◽  
T. Howard ◽  
D. Burk
Keyword(s):  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Ehrlich Ascites
Sign in / Sign up

Export Citation Format

Share Document