Protection of rabbit kidney from ischemia/reperfusion injury by green tea polyphenol pretreatment

2007 ◽  
Vol 30 (11) ◽  
pp. 1447-1454 ◽  
Author(s):  
Dong Kyun Rah ◽  
Dong-Wook Han ◽  
Hyun Sook Baek ◽  
Suong-Hyu Hyon ◽  
Beyoung Yun Park ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rabbit Kidney ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol

scholarly journals Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats

2004 ◽  
Vol 10 (1-6) ◽  
pp. 55-62 ◽  
Author(s):  
Rajesh Aneja ◽  
Paul W. Hake ◽  
Timothy J. Burroughs ◽  
Alvin G. Denenberg ◽  
Hector R. Wong ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

Green tea polyphenol extract attenuates ischemia/reperfusion injury of the gut

2005 ◽  
Vol 371 (5) ◽  
pp. 364-374 ◽  
Author(s):  
Carmelo Muià ◽  
Emanuela Mazzon ◽  
Rosanna Di Paola ◽  
Tiziana Genovese ◽  
Marta Menegazzi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol

Effect of green tea extracted polyphenol on ischemia/reperfusion injury after cold preservation of rat lung

2003 ◽  
Vol 35 (1) ◽  
pp. 138-139 ◽  
Author(s):  
M Omasa ◽  
T Fukuse ◽  
K Matsuoka ◽  
K Inui ◽  
S.H Hyon ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Lung ◽  
Cold Preservation

Prevention of hepatic ischemia-reperfusion injury by green tea extract

2002 ◽  
Vol 283 (4) ◽  
pp. G957-G964 ◽  
Author(s):  
Zhi Zhong ◽  
Matthias Froh ◽  
Henry D. Connor ◽  
Xiangli Li ◽  
Lars O. Conzelmann ◽  
...  
Keyword(s):  
Free Radicals ◽  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Green Tea Extract ◽  
Pathological Changes ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion ◽  
Tea Extract

These experiments were designed to determine whether green tea extract (GTE), which contains polyphenolic free radical scavengers, prevents ischemia-reperfusion injury to the liver. Rats were fed a powdered diet containing 0–0.3% GTE starting 5 days before hepatic warm ischemia and reperfusion. Free radicals in bile were trapped with the spin-trapping reagent α-(4-pyridyl-1-oxide)- N- tert-butylnitrone (4-POBN) and measured using electron spin resonance spectroscopy. Hepatic ischemia-reperfusion increased transaminase release and caused pathological changes including focal necrosis and hepatic leukocyte infiltration in the liver. Transaminase release was diminished by over 85% and pathological changes were almost totally blocked by 0.1% dietary GTE. Ischemia-reperfusion increased 4-POBN/radical adducts in bile nearly twofold, an effect largely blocked by GTE. Epicatechin, one of the major green tea polyphenols, gave similar protection as GTE. In addition, hepatic ischemia-reperfusion activated NF-κB and increased TNF-α mRNA and protein expression. These effects were all blocked by GTE. Taken together, these results demonstrate that GTE scavenges free radicals in the liver after ischemiareoxygenation, thus preventing formation of toxic cytokines. Therefore, GTE could prove to be effective in decreasing hepatic injury in disease states where ischemia-reperfusion occurs.

The effect of aprotinin on ischemia–reperfusion injury in the rabbit kidney

2001 ◽  
Vol 44 (6) ◽  
pp. 455-460 ◽  
Author(s):  
Zeliha Özer ◽  
Nehir Sucu ◽  
Duygu Düşmez ◽  
Lülüfer Tamer ◽  
Ali Aydin Altunkan ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rabbit Kidney

Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-Acetylcysteine as antioxidants

2000 ◽  
Vol 32 (2) ◽  
pp. 475-476 ◽  
Author(s):  
J Pincemail ◽  
J.O Defraigne ◽  
O Detry ◽  
C Franssen ◽  
M Meurisse ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rabbit Kidney

scholarly journals Epicatechin Gallate Protects HBMVECs from Ischemia/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Bing Fu ◽  
Qinghong Zeng ◽  
Zhaoting Zhang ◽  
Mingyue Qian ◽  
Jiechun Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Migration ◽  
Reperfusion Injury ◽  
Green Tea ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Glucose Deprivation ◽  
Tube Formation ◽  
Epicatechin Gallate

Green tea is one of the most beverages with antioxidants and nutrients. As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study. Cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endothelial cells (HBMVECs) after oxygen-glucose deprivation/reoxygenation (OGD/R) to investigate potential anti-ischemia/reperfusion injury properties of ECG in vitro. Markers of oxidative stress as ROS, LDH, MDA, and SOD were further assayed in our study. Data indicated that ECG could affect neovascularization and promote cell proliferation, tube formation, and cell migration while inhibiting apoptosis and autophagy through affecting VEGF, Bcl-2, BAX, LC3B, caspase 3, mTOR, and Beclin-1 expression. All the data suggested that ECG may be protective for the brain against ischemia/reperfusion injury by promoting neovascularization, alleviating apoptosis and autophagy, and promoting cell proliferation in HBMVECs of OGD/R.

Sign in / Sign up

Export Citation Format

Share Document