Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cells

2007 ◽  
Vol 30 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Hae-Young Yong ◽  
Aree Moon
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Invasive Phenotype

Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein

2007 ◽  
Vol 85 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Jie Liang ◽  
Guanhong Luo ◽  
Xiaoxuan Ning ◽  
Yongquan Shi ◽  
Huihong Zhai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Prion Protein ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Cellular Prion Protein ◽  
Primary Role ◽  
Gastric Cancer Cells ◽  
Intracellular Ca

The prion protein (PrPC) has a primary role in the pathogenesis of transmissible spongiform encephalopathies, which causes prion disorders partially due to Ca2+ dysregulation. In our previous work, we found that overexpressed PrPC in gastric cancer was involved in apoptosis, cell proliferation, and metastasis of gastric cancer. To better understand how PrPC acts in gastric cancer, a human microarray was performed to select differentially regulated genes that correlate with the biological function of PrPC. The microarray data were analyzed and revealed 3798 genes whose expression increased at least 2-fold in gastric cancer cells transfected with PrPC. These genes encode proteins involved in several aspects of cell biology, among which, we specially detected molecules related to calcium, especially the S100 calcium-binding proteins, and found that PrPC upregulates S100A1, S100A6, S100B, and S100P but downregulates CacyBP in gastric cancer cells. We also found that intracellular Ca2+ levels in cells transfected with PrPC increased, whereas these levels decreased in knockdowns of these cells. Taken together, PrPC might increase intracellular Ca2+, partially through calcium-binding proteins, or PrPC might upregulate the expression of S100 proteins, partially through stimulating the intracellular calcium level in gastric cancer. Though the underlying mechanisms need further exploration, this study provides a new insight into the role of PrPC in gastric cancer and enriches our knowledge of prion protein.

Helicobacter pyloriinduces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells

2016 ◽  
Vol 55 (12) ◽  
pp. 2236-2246 ◽  
Author(s):  
Hoang-Kieu-Chi Ngo ◽  
Hee Geum Lee ◽  
Juan-Yu Piao ◽  
Xiancai Zhong ◽  
Ha-Na Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Snail Expression ◽  
Gsk 3Β

scholarly journals TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells

IUBMB Life ◽  
2016 ◽  
Vol 68 (5) ◽  
pp. 355-364 ◽  
Author(s):  
Wei Deng ◽  
Jin Wang ◽  
Jun Zhang ◽  
Jun Cai ◽  
Zhigang Bai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Cre-loxP-mediated bax gene activation reduces growth rate and increases sensitivity to chemotherapeutic agents in human gastric cancer cells

2000 ◽  
Vol 7 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Koga Komatsu ◽  
Susumu Suzuki ◽  
Tooru Shimosegawa ◽  
Jun-ichi Miyazaki ◽  
Takayoshi Toyota
Keyword(s):  
Gastric Cancer ◽  
Growth Rate ◽  
Cancer Cells ◽  
Gene Activation ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Bax Gene

Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker

2011 ◽  
Vol 5 (9-10) ◽  
pp. 567-567
Author(s):  
Chien-Wei Tseng ◽  
Jyh-Chin Yang ◽  
Chiung-Nien Chen ◽  
Hsuan-Cheng Huang ◽  
Kai-Neng Chuang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Prognostic Biomarker ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells

2011 ◽  
Vol 27 (4) ◽  
pp. 1111-1115 ◽  
Author(s):  
HYUNSOO SHIN ◽  
YEO SONG LEE ◽  
YONG CHAN LEE
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Sodium Butyrate ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells
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