scholarly journals Cre-loxP-mediated bax gene activation reduces growth rate and increases sensitivity to chemotherapeutic agents in human gastric cancer cells

2000 ◽  
Vol 7 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Koga Komatsu ◽  
Susumu Suzuki ◽  
Tooru Shimosegawa ◽  
Jun-ichi Miyazaki ◽  
Takayoshi Toyota
Keyword(s):  
Gastric Cancer ◽  
Growth Rate ◽  
Cancer Cells ◽  
Gene Activation ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Bax Gene

Enhanced bax gene expression reduces cell growth and sensitizes human gastric cancer cells to chemotherapeutic agents

2000 ◽  
Vol 118 (4) ◽  
pp. A535
Author(s):  
Koga Komatsu ◽  
Jun-ichi Miyazaki ◽  
Susumu Suzuki ◽  
Michiro Otaka ◽  
Sumio Watanabe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Bax Gene

scholarly journals The Herb Medicine Formula “Chong Lou Fu Fang” Increases the Cytotoxicity of Chemotherapeutic Agents and Down-Regulates the Expression of Chemotherapeutic Agent Resistance-Related Genes in Human Gastric Cancer CellsIn Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Yongping Liu ◽  
Yang Ling ◽  
Wenjing Hu ◽  
Li Xie ◽  
Lixia Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Chemotherapeutic Agent ◽  
Chemotherapeutic Agents ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Herb Medicine

The herb medicine formula “Chong Lou Fu Fang” (CLFF) has efficacy in inhibiting the proliferation of human gastric cancerin vitroandin vivo. To explore the potentially useful combination of CLFF with chemotherapeutic agents commonly used in gastric cancer therapy, we assess the interaction between CLFF and these chemotherapeutic agents in both SGC-7901 cell lines and BGC-823 cell lines using a median effect analysis and apoptosis analysis, and we also investigate the influence of CLFF on chemotherapeutic agent-associated gene expression. The synergistic analysis indicated that CLFF had a synergistic effect on the cytotoxicity of 5-fluorouracil (5-FU) in a relative broad dose inhibition range (20–95% fraction affected in SGC-7901cell lines and 5–65% fraction affected in BGC-823 cell lines), while the synergistic interaction between CLFF and oxaliplatin or docetaxel only existed in a low dose inhibition range (≤50% fraction affected in both cell lines). Combination of CLFF and chemotherapeutic agents could also induce apoptosis in a synergistic manner. After 24 h, CLFF alone or CLFF combination with chemotherapeutic agents could significantly suppress the levels of expression of chemotherapeutic agent resistance related genes in gastric cancer cells. Our findings indicate that there are useful synergistic interactions between CLFF and chemotherapeutic agents in gastric cancer cells, and the possible mechanisms might be partially due to the down-regulation of chemotherapeutic agent resistance related genes and the synergistic apoptotic effect.

Helicobacter pyloriinduces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells

2016 ◽  
Vol 55 (12) ◽  
pp. 2236-2246 ◽  
Author(s):  
Hoang-Kieu-Chi Ngo ◽  
Hee Geum Lee ◽  
Juan-Yu Piao ◽  
Xiancai Zhong ◽  
Ha-Na Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Snail Expression ◽  
Gsk 3Β

scholarly journals TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells

IUBMB Life ◽  
2016 ◽  
Vol 68 (5) ◽  
pp. 355-364 ◽  
Author(s):  
Wei Deng ◽  
Jin Wang ◽  
Jun Zhang ◽  
Jun Cai ◽  
Zhigang Bai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker

2011 ◽  
Vol 5 (9-10) ◽  
pp. 567-567
Author(s):  
Chien-Wei Tseng ◽  
Jyh-Chin Yang ◽  
Chiung-Nien Chen ◽  
Hsuan-Cheng Huang ◽  
Kai-Neng Chuang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Prognostic Biomarker ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells

2011 ◽  
Vol 27 (4) ◽  
pp. 1111-1115 ◽  
Author(s):  
HYUNSOO SHIN ◽  
YEO SONG LEE ◽  
YONG CHAN LEE
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Sodium Butyrate ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells

2009 ◽  
Vol 37 (5) ◽  
pp. 2189-2198 ◽  
Author(s):  
Lan Shi ◽  
Mei Zhao ◽  
Qing Luo ◽  
Yi-Ming Ma ◽  
Jia-Ling Zhong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration
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