scholarly journals Responses of EEG, cerebral oxygen consumption and blood flow to peripheral nerve stimulation during thiopentone anaesthesia in the dog

Author(s):  
Yoshitoyo Miyauchi ◽  
Takefumi Sakabe ◽  
Tsuyoshi Maekawa ◽  
Toshizoh Ishikawa ◽  
Hiroshi Takeshita
1976 ◽  
Vol 231 (2) ◽  
pp. 489-494 ◽  
Author(s):  
ET MacKenzie ◽  
J McCulloch ◽  
AM Harper

The influence of brain norepinephrine on cerebral metabolism and blood flow was examined because exogenous norepinephrine, administered in a way that the blood-brain barrier is bypassed, has been shown to effect pronounced changes in the cerebral circulation. Reserpine (40 mug/kg, by intracarotid infusion) was administered in order to release brain norepinephrine in five anesthetized baboons. Reserpine significantly increased cerebral oxygen consumption (23%) and cerebral blood flow (50%). This response lasted for approximately 60 min. In a further five animals, effects of central beta-adrenoreceptor blockade were studied. Pro pranolol (12 mug/kg-min) produced an immediate, significant reduction in both cerebral oxygen consumption (40%) and cerebral glucose uptake (39%). Cerebral blood flow was reduced minimally. However, the responsiveness of the cerebral circulation to induced hypercapnia was severely attenuated from a gradient of 3.22 before, to 1,11 after, administration. These experiments suggest that central norepinephrine can influence the cerebral circulation primarily through noradrenergic effects on brain metabolism.


1989 ◽  
Vol 70 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Michel Pinaud ◽  
Réml Souron ◽  
Jean-Noël Lelausque ◽  
Marie-France Gazeau ◽  
Youenn Lajat ◽  
...  

1978 ◽  
Vol 44 (3-4) ◽  
pp. 151-160 ◽  
Author(s):  
J. Hamer ◽  
K. Wiedemann ◽  
H. Berlet ◽  
F. Weinhardt ◽  
S. Hoyer

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