scholarly journals Fentanyl increases catecholamine oxidation current measured byin vivo voltammetry in the rat striatum

1989 ◽  
Vol 36 (2) ◽  
pp. 155-159 ◽  
Author(s):  
Brian Milne ◽  
Luc Quintin ◽  
Jean-François Pujol

1988 ◽  
Vol 254 (2) ◽  
pp. R296-R301
Author(s):  
K. V. Thrivikraman ◽  
D. E. Carlson ◽  
D. S. Gann

Push-pull perfusion was used to determine monoaminergic activity in the locus coeruleus (LC) of alpha-chloralose-urethan-anesthetized cats after 20% hemorrhage. Blood was withdrawn from 0 to 3 min and reinfused from 10 to 13 min. Continuous 5-min interval samples of perfusate were collected from -5 to 15 min. Concentrations of the monoamines were determined using high-performance liquid chromatography with electrochemical detection. The perfusion sites (n = 21) were identified histologically. In a group of eight contiguous sites in the ventral LC (vLC), 4-hydroxy-3-methoxy-phenyl(ethylene)glycol (MHPG) increased significantly from 0.50 +/- 0.22 (control) to 1.19 +/- 0.42 pmol/5 min during the first 5 min after hemorrhage (P less than 0.05). This response differed significantly from that obtained at the remaining 13 sites. Other metabolites were not often detectable for many sites either within or outside vLC, and their responses to hemorrhage were not significant. The response of MHPG in the vLC indicates that norepinephrine (NE) turnover increases in this area selectively and implicates NE in the increase in the catecholamine oxidation current reported previously using in vivo voltammetry. Since the vLC was shown previously to facilitate adrenocorticotropin (ACTH) release, the increase in NE turnover after hemorrhage could induce ACTH release. This increase may also act locally to modulate the ascending hemodynamic signal.



2020 ◽  
Vol 86 (12) ◽  
pp. 15-22
Author(s):  
N. A. Bulayev ◽  
E. V. Chukhlantseva ◽  
O. V. Starovoytova ◽  
A. A. Tarasenko

The content of uranium and plutonium is the main characteristic of mixed uranium-plutonium oxide fuel, which is strictly controlled and has a very narrow range of the permissible values. We focused on developing a technique for measuring mass fractions of uranium and plutonium by controlled potential coulometry using a coulometric unit UPK-19 in set with a R-40Kh potentiostat-galvanostat. Under conditions of sealed enclosures, a special design of the support stand which minimized the effect of fluctuations in ambient conditions on the signal stability was developed. Optimal conditions for coulometric determination of plutonium and uranium mass fractions were specified. The sulfuric acid solution with a molar concentration of 0.5 mol/dm3 was used as a medium. Lead ions were introduced into the background electrolyte to decrease the minimum voltage of hydrogen reduction to –190 mV. The addition of aluminum nitride reduced the effect of fluoride ions participating as a catalyst in dissolving MOX fuel samples, and the interfering effect of nitrite ions was eliminated by introducing a sulfamic acid solution into the cell. The total content of uranium and plutonium was determined by evaluation of the amount of electricity consumed at the stage of uranium and plutonium co-oxidation. Plutonium content was measured at the potentials, at which uranium remains in the stable state, which makes it possible to subtract the contribution of plutonium oxidation current from the total oxidation current. The error characteristics of the developed measurement technique were evaluated using the standard sample method and the real MOX fuel pellets. The error limits match the requirements set out in the specifications for MOX fuel. The technique for measuring mass fractions of uranium and plutonium in uranium-plutonium oxide nuclear fuel was certified. The relative measurement error of the mass fraction of plutonium and uranium was ±0.0070 and ±0.0095, respectively. The relative error of the ratio of the plutonium mass fraction to the sum of mass fractions of uranium and plutonium was ±0.0085.





Life Sciences ◽  
1982 ◽  
Vol 30 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Yuen-Sum Lao ◽  
Margaret E. Gnegy




2021 ◽  
Vol 373 ◽  
pp. 137909
Author(s):  
C.Y. Sano Moyeme ◽  
R. El Hage ◽  
A. Hassan ◽  
F. Chauvet ◽  
L. Cassayre ◽  
...  


FEBS Letters ◽  
1980 ◽  
Vol 121 (1) ◽  
pp. 133-138 ◽  
Author(s):  
H. Gorissen ◽  
B. Ilien ◽  
G. Aerts ◽  
P. Laduron






1988 ◽  
Vol 20 ◽  
pp. 215
Author(s):  
L. Lucchi ◽  
C.M. Lopez ◽  
R.M. Moresco ◽  
S. Govoni ◽  
M. Trabucchi


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