Theophylline pharmacokinetics following single and repeated administration of slow-release capsules

1988 ◽  
Vol 13 (4) ◽  
pp. 225-230 ◽  
Author(s):  
J. Torrent ◽  
I. Izquierdo ◽  
M. J. Barbanoj ◽  
R. Obach ◽  
M. Nomen ◽  
...  
Keyword(s):  
Slow Release ◽  
Repeated Administration ◽  
Single And Repeated Administration

THC and CBD concentrations in blood, oral fluid and urine following a single and repeated administration of “light cannabis”

2020 ◽  
Vol 58 (5) ◽  
pp. 682-689 ◽  
Author(s):  
Roberta Pacifici ◽  
Simona Pichini ◽  
Manuela Pellegrini ◽  
Maria Concetta Rotolo ◽  
Raffaele Giorgetti ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Oral Fluid ◽  
Repeated Administration ◽  
Urine Samples ◽  
Gas Chromatography Mass Spectrometry ◽  
Sample Collection ◽  
Valuable Alternative ◽  
The Mean ◽  
Single And Repeated Administration

AbstractBackground“Light cannabis” is a product legally sold in Europe with Δ9-tetrahydrocannabinol (THC) concentration lower than 0.2% and variable cannabidiol (CBD) content. We studied THC and CBD excretion profiles in blood, oral fluid (OF) and urine after smoking one or four light cannabis cigarettes.MethodsBlood, OF and urine samples were obtained from six healthy light cannabis consumers after smoking one 1 g cigarette containing 0.16% THC and 5.8% CBD and from six others after smoking four 1 g cigarettes within 4 h. Sample collection began 0.5 and 4.5 h after smoking one or four cigarettes, respectively. Cannabinoid concentrations were quantified by gas chromatography-mass spectrometry (GC-MS).ResultsAt the first collection, the highest THC and CBD concentrations occurred in blood (THC 7.0–10.8 ng/mL; CBD 30.2–56.1 ng/mL) and OF (THC 5.1–15.5 ng/mL; CBD 14.2–28.1 ng/mL); similar results occurred 0.5 h after the last of four cigarettes in blood (THC 14.1–18.2 ng/mL, and CBD 25.6–45.4 ng/mL) and OF (THC 11.2–24.3 ng/mL; CBD 14.4–37.0 ng/mL). The mean OF to blood ratio ranged from 0.6 to 1.2 after one and 0.6 to 1.9 after four light cannabis cigarettes. THC/CBD ratios in blood and OF were never greater than 2. Urinary 11-nor-9-carboxy-THC concentrations peaked 8 h after one and four cigarettes.ConclusionsOF was a valuable alternative to blood in monitoring consumption of light cannabis. Blood and OF THC/CBD concentration ratios, never exceeded 2, possibly providing a useful biomarker to identify light cannabis vs illegal higher THC cannabis use, where THC/CBD ratios are generally greater than 10.

scholarly journals Studies on nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) in rats.

1987 ◽  
Vol 151 (2) ◽  
pp. 129-135 ◽  
Author(s):  
YUTAKA MIZUSHIMA ◽  
HIROTOKU NAGAHAMA ◽  
AKIHITO YOKOYAMA ◽  
TOSHIHIKO MORIKAGE ◽  
SABURO YANO
Keyword(s):  
Repeated Administration ◽  
Single And Repeated Administration

scholarly journals EEG profile of litoxetine after single and repeated administration in healthy volunteers.

1994 ◽  
Vol 37 (2) ◽  
pp. 157-163 ◽  
Author(s):  
A Patat ◽  
S Trocherie ◽  
JJ Thebault ◽  
P Rosenzweig ◽  
C Dubruc ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Repeated Administration ◽  
Single And Repeated Administration
Sign in / Sign up

Export Citation Format

Share Document