Pharmaceutical Potential of Porous Particles

2006 ◽  
Vol 4 (12) ◽  
pp. 16-18
Keyword(s):  
Porous Particles

Extra-Column Effects in Determination of Rate Parameters by the Chromatographic Method

1996 ◽  
Vol 61 (6) ◽  
pp. 844-855 ◽  
Author(s):  
Olga Šolcová ◽  
Petr Schneider
Keyword(s):  
Chromatographic Method ◽  
Dynamic Method ◽  
Axial Dispersion ◽  
Transport Parameters ◽  
Porous Particles ◽  
Loop Detector ◽  
Single Pellet ◽  
Set Up ◽  
Extra Column Effects

It was shown that the sampling loop, detector and connecting elements in the chromatographic set-up for determination of transport parameters by the dynamic method significantly influence the response peaks from columns packed with porous or nonporous particles. A method, based on the use of convolution theorem, was developed which can take these effects into account. The applicability of this method was demonstrated on the case of axial dispersion in a single-pellet-string column (SPSR) packed with nonporous particles. It is possible to handle also responses from columns packed with porous particles by a similar procedure.

Engineering gas-foamed large porous particles for efficient local delivery of macromolecules to the lung

2010 ◽  
Vol 41 (1) ◽  
pp. 60-70 ◽  
Author(s):  
Francesca Ungaro ◽  
Concetta Giovino ◽  
Ciro Coletta ◽  
Raffaella Sorrentino ◽  
Agnese Miro ◽  
...  
Keyword(s):  
Local Delivery ◽  
Porous Particles

scholarly journals Wider Pore Superficially Porous Particles for Peptide Separations by HPLC

2010 ◽  
Vol 48 (7) ◽  
pp. 566-571 ◽  
Author(s):  
S. A. Schuster ◽  
B. M. Wagner ◽  
B. E. Boyes ◽  
J. J. Kirkland
Keyword(s):  
Porous Particles ◽  
Superficially Porous Particles ◽  
Peptide Separations

Drying Characteristics of Porous Materials in a Fluidized Bed of Hygroscopic Porous Particles

2005 ◽  
Vol 38 (12) ◽  
pp. 976-982 ◽  
Author(s):  
Yuji Tatemoto ◽  
Masaya Tsunekawa ◽  
Yoshihide Mawatari ◽  
Yoichi Shiota ◽  
Katsuji Noda
Keyword(s):  
Porous Materials ◽  
Fluidized Bed ◽  
Drying Characteristics ◽  
Porous Particles

scholarly journals Temperature Effects on Retention and Separation of PAHs in Reversed-Phase Liquid Chromatography Using Columns Packed with Fully Porous and Core-Shell Particles

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Christophe Waterlot ◽  
Anaïs Goulas
Keyword(s):  
Limit Of Detection ◽  
Tap Water ◽  
Reversed Phase ◽  
Chromatographic Behavior ◽  
Core Shell ◽  
Reversed Phase Liquid Chromatography ◽  
Porous Particles ◽  
Phase Liquid ◽  
Effects Of Temperature ◽  
Shell Particles

Effects of temperature on the reversed-phase chromatographic behavior of PAHs were investigated on three columns. The first was the recent C18column (250 mm × 4.6 mm) packed with 5 µm core-shell particles while the others were more conventional C18columns (250 mm × 4.6 mm) packed with fully porous particles. Among the 16 PAHs studied, special attention has been paid to two pairs of PAHs, fluorene/acenaphthene and chrysene/benzo[a]anthracene, which often present coeluting problems. Due to the low surface area of the core-shell particles, lowest retention time of each PAH was highlighted and effects of the temperature on the separation of PAHs were negligible in regard to those using columns packed with fully porous particles. For each PAH studied, it was demonstrated that peaks were symmetrical and may be considered as Gaussian peaks when the column packed with core-shell particle was employed. In the best condition, the separation of PAHs was conducted at 16°C under very low pressure values (670–950 psi = 46–65 bars). Depending on PAHs, the limit of detection ranged from 0.88 to 9.16 μg L−1. Analysis of spiked acetonitrile samples with PAHs at 10 and 50 µg L−1and tap water at 10 µg L−1gave very good recoveries (94%–109.3%) and high precision (1.1%–3.5%).

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