Acute and chronic effects of high glucocorticoid levels on hypothalamic-pituitary-thyroid axis in man

1992 ◽  
Vol 15 (6) ◽  
pp. 437-441 ◽  
Author(s):  
D. Rubello ◽  
N. Sonino ◽  
D. Casara ◽  
M. E. Girelli ◽  
B. Busnardo ◽  
...  
Keyword(s):  
Chronic Effects ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Acute And Chronic Effects

Acute and chronic effects of dextro-thyroxine on pituitary thyroid axis and on reverse triiodothyronine production in euthyroid subjects

1987 ◽  
Vol 10 (1) ◽  
pp. 73-77 ◽  
Author(s):  
B. Busnardo ◽  
N. Simioni ◽  
M. E. Girelli ◽  
T. Rampazzo ◽  
A. Pagnan ◽  
...  
Keyword(s):  
Reverse Triiodothyronine ◽  
Chronic Effects ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Acute And Chronic Effects

Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas

1995 ◽  
Vol 133 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Annamaria Colao ◽  
Bartolomeo Merola ◽  
Diego Ferone ◽  
Paolo Marzullo ◽  
Gaetana Cerbone ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenomas ◽  
Acute Administration ◽  
Α Subunit ◽  
Chronic Effects ◽  
Igf I ◽  
Thyroid Axis ◽  
Acute And Chronic Effects ◽  
Non Functioning Pituitary Adenomas

Colao A, Merola B, Ferone D, Marzullo P, Cerbone G, Longobardi S, Di Somma C, Lombardi G. Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. Eur J Endocrinol 1995;133:189–94. ISSN 0804–4643 The effect of somatostatin on thyroid function was studied in 12 patients with growth hormone (GH)-secreting and eight patients with clinically non-functioning adenomas (NFA) and normal pituitary/ thyroid axis; the patients were subjected to the administration of octreotide (OCT), which is a longacting somatostatin analog. All the patients received an acute test with 100 μg of OCT, both short term (1 month) and long term (6 months), with doses ranging from 300 to 600 μg/day, Serum thyroxine (T4). triiodothyronine (T3), free T4, free T3, thyroglobulin and basal and thyrotropin (TSH)-releasing hormone (TRH)-stimulated TSH were evaluated before and after 1 and 6 months of therapy. Circulating GH and insulin-like growth-factor I (IGF-I) in acromegalics and GH, IGF-I and α-subunit in NFA were assessed at baseline and every month. The acute administration of 100 μg of OCT significantly reduced the TSH response to TRH (p < 0.01) in both acromegalics and NFA. In all the patients OCT administration caused a significant decrease of GH, IGF-I and α-subunit levels (p < 0.01). In addition, after 1 month of therapy both baseline and TRH-induced TSH secretion were decreased significantly in acromegalics and NFA. After 6 months of therapy, baseline and TRH-induced TSH was still reduced in NFA. Conversely, in acromegalics, baseline TSH levels were increased while TSH response to TRH was inhibited. No change of T4, T3, free T4 and free T3 was observed in NFA, whereas a slight but significant increase of T4 and decrease of T3 was recorded in acromegalics. In conclusion, OCT does seem to possess long-term suppressive effects on TSH response to TRH, both in acromegalics and NFA. The lack of basal TSH level inhibition in acromegalics could depend on the restored peripheral conversion of T4 into T3 due to the normalized GH levels during long-term OCT administration. Annamaria Colao, Corso Europa 63, 80127 Napoli, Italy

Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search

Impact ◽  
2020 ◽  
Vol 2020 (3) ◽  
pp. 63-65
Author(s):  
Tomomi Higashi
Keyword(s):  
Air Pollutants ◽  
Genetic Factors ◽  
Long Term Effects ◽  
Emergency Rooms ◽  
Improve Treatment ◽  
Treatment And Prevention ◽  
Chronic Effects ◽  
Difficulty Breathing ◽  
Acute And Chronic Effects

Talk to any allergy sufferer and they will tell you how awful it can be. Runny noses, itchy eyes, coughing and difficulties breathing. For many these symptoms rise only to the level of annoyance and can be avoided by steering clear of the source of their allergy. What many people don't realise though is that allergies can become a far more serious issue for a large segment of the population. Shortness of breath and difficulty breathing due to allergies bring many people to emergency rooms and these are just the acute symptoms. Along with the potential for an allergic attack during a windy or dusty day, researchers and medical professionals are beginning to recognise that there are chronic, long term effects associated with allergies. In order to mitigate both the acute and chronic effects of allergies a better understanding of how genetic factors combine with environmental conditions to produce the ranges of symptoms and effects of allergy suffers is needed. Professor Tomomi Higashi, from the Department of Hygiene at Kanazawa University in Japan, is an expert in this field and is currently working to improve treatment and prevention of allergic disease.

Acute and Chronic Effects of Normothermic Anoxia on Canine Hearts

Circulation ◽  
1971 ◽  
Vol 43 (5s1) ◽  
Author(s):  
L. MAXIMILIAN BUJA ◽  
SIDNEY LEVITSKY ◽  
VICTOR J. FERRANS ◽  
SHERMAN G. SOUTHER ◽  
WILLIAM C. ROBERTS ◽  
...  
Keyword(s):  
Chronic Effects ◽  
Acute And Chronic Effects

Acute and Chronic Effects of Exercise on Baroreflexes in Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 714-719 ◽  
Author(s):  
Gustavo José Justo Silva ◽  
Patricia Chakur Brum ◽  
Carlos Eduardo Negrão ◽  
Eduardo Moacyr Krieger
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Chronic Effects ◽  
Acute And Chronic Effects
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