Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search

Impact ◽  
2020 ◽  
Vol 2020 (3) ◽  
pp. 63-65
Author(s):  
Tomomi Higashi
Keyword(s):  
Air Pollutants ◽  
Genetic Factors ◽  
Long Term Effects ◽  
Emergency Rooms ◽  
Improve Treatment ◽  
Treatment And Prevention ◽  
Chronic Effects ◽  
Difficulty Breathing ◽  
Acute And Chronic Effects

Talk to any allergy sufferer and they will tell you how awful it can be. Runny noses, itchy eyes, coughing and difficulties breathing. For many these symptoms rise only to the level of annoyance and can be avoided by steering clear of the source of their allergy. What many people don't realise though is that allergies can become a far more serious issue for a large segment of the population. Shortness of breath and difficulty breathing due to allergies bring many people to emergency rooms and these are just the acute symptoms. Along with the potential for an allergic attack during a windy or dusty day, researchers and medical professionals are beginning to recognise that there are chronic, long term effects associated with allergies. In order to mitigate both the acute and chronic effects of allergies a better understanding of how genetic factors combine with environmental conditions to produce the ranges of symptoms and effects of allergy suffers is needed. Professor Tomomi Higashi, from the Department of Hygiene at Kanazawa University in Japan, is an expert in this field and is currently working to improve treatment and prevention of allergic disease.

Volatile Substance Abuse: A Review of Possible Long-Term Neurological, Intellectual and Psychiatric Sequelae

1986 ◽  
Vol 148 (3) ◽  
pp. 235-246 ◽  
Author(s):  
Maria A. Ron
Keyword(s):  
Present Knowledge ◽  
Long Term Effects ◽  
Chronic Effects ◽  
Structural Brain Damage ◽  
Psychiatric Sequelae ◽  
Volatile Substance Abuse ◽  
Psychiatric Manifestations ◽  
Acute And Chronic Effects

The possibility that chronic abuse of volatile substances can cause permanent neurological, psychiatric, and intellectual sequelae is critically reviewed. Toluene, present in the commonly used adhesives, is most often implicated in ‘glue sniffing’; this review focuses on its potential long-term effects. Many criticisms—particularly poor matching of control samples and inability to distinguish between acute and chronic effects—can be levelled at the available studies, while no adequate follow-up studies have been performed. In the light of present knowledge, the possibility that permanent structural brain damage, with accompanying psychiatric manifestations, results from solvent abuse remains inconclusive.

LONG TERM EFFECTS OF THYROID STIMULATING HORMONE AND INSULIN ON INTRACELLULAR pH IN FRTL-5 CELLS

1992 ◽  
Vol 133 (2) ◽  
pp. R9-R11
Author(s):  
A.M. Wood ◽  
S.P. Bidey ◽  
J. Soden ◽  
W.R. Robertson
Keyword(s):  
Intracellular Ph ◽  
Small Groups ◽  
Thyroid Stimulating Hormone ◽  
Ph Sensitive ◽  
Long Term Effects ◽  
Bicarbonate Ions ◽  
Chronic Effects ◽  
Petri Dishes ◽  
Presence And Absence

ABSTRACT We have studied the chronic effects of TSH (100μU/ml) and insulin (10μg/ml) on intracellular pH (pHi) in FRTL-5 cells using the pH sensitive probe 2′7-bis (2-carboxyethyl-5′-6′) carboxyfluorescein. FRTL-5 cells were cultured on Petri dishes either in the presence of 4H, ie. Coons F-12 containing cortisol (10nM), transferrin (0.5μg/ml), glycyl-histidyl lysine acetate (10ng/ml) and somatostatin (10μg/ml), or with 4H+insulin (5H), 4H+TSH, or 4H+TSH+insulin (6H). pHi was measured in small groups of cells by microspectrofluorimetry both in the presence and absence of bicarbonate ions after cells had been deprived of serum for at least a day. In

Long-term effects of ambient air pollutants to blood lipids and dyslipidemias in a Chinese rural population

2020 ◽  
Vol 256 ◽  
pp. 113403 ◽  
Author(s):  
Shuyuan Mao ◽  
Gongbo Chen ◽  
Feifei Liu ◽  
Na Li ◽  
Chongjian Wang ◽  
...  
Keyword(s):  
Rural Population ◽  
Air Pollutants ◽  
Blood Lipids ◽  
Ambient Air ◽  
Long Term Effects ◽  
Ambient Air Pollutants

Longitudinal Genetic Analysis of Plasma Lipids

2006 ◽  
Vol 9 (4) ◽  
pp. 550-557 ◽  
Author(s):  
Rita P. Middelberg ◽  
Nicholas G. Martin ◽  
John B. Whitfield
Keyword(s):  
Environmental Factors ◽  
Measurement Errors ◽  
Genetic Factors ◽  
Plasma Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Study Participant ◽  
Biological Variation ◽  
Long Term Effects

AbstractThe consensus from published studies is that plasma lipids are each influenced by genetic factors, and that this contributes to genetic variation in risk of cardiovascular disease. Heritability estimates for lipids and lipoproteins are in the range .48 to .87, when measured once per study participant. However, this ignores the confounding effects of biological variation measurement error and ageing, and a truer assessment of genetic effects on cardiovascular risk may be obtained from analysis of longitudinal twin or family data. We have analyzed information on plasma high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides, from 415 adult twins who provided blood on two to five occasions over 10 to 17 years. Multivariate modeling of genetic and environmental contributions to variation within and across occasions was used to assess the extent to which genetic and environmental factors have long-term effects on plasma lipids. Results indicated that more than one genetic factor influenced HDL and LDL components of cholesterol, and triglycerides over time in all studies. Nonshared environmental factors did not have significant long-term effects except for HDL. We conclude that when heritability of lipid risk factors is estimated on only one occasion, the existence of biological variation and measurement errors leads to underestimation of the importance of genetic factors as a cause of variation in long-term risk within the population. In addition our data suggest that different genes may affect the risk profile at different ages.

Review of Environmental Accidents and Incidents

1994 ◽  
Vol 29 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Palle Lindgaard-Jørgensen ◽  
Klavs Bender
Keyword(s):  
Environmental Conditions ◽  
Long Term Effects ◽  
Short Term ◽  
Ecological Consequences ◽  
Accident Investigation ◽  
Environmental Consequences ◽  
Environmental Accidents ◽  
Chronic Effects ◽  
Spill Site

This paper reviewed the environmental consequences reported in more than three thousand accidents. Fifty-nine of the accidents reported environmental consequences, seven reported no environmental consequences, and for the remaining accidents, no information was available. Generally, the properties of a chemical, the dilution of the amount released, and the environmental conditions at the spill site are the parameters that determine the short-term environmental consequences. To evaluate the long-term effects, which have almost never been studied in the accidents reviewed, persistence, the tendency to accumulate in sediment and biota, and the long-term sub-lethal and chronic effects are the main parameters to be considered. While ecological consequences of accidents have been investigated more frequently in recent years, there has been no consistency in reporting methodology. An accident investigation methodology and a reporting format should therefore be developed and implemented on a broad international scale.

scholarly journals Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

2012 ◽  
Vol 302 (1) ◽  
pp. R75-R83 ◽  
Author(s):  
Scott C. Thomson ◽  
Timo Rieg ◽  
Cynthia Miracle ◽  
Hadi Mansoury ◽  
Jean Whaley ◽  
...  
Keyword(s):  
Large Fraction ◽  
Streptozotocin Diabetes ◽  
Tubuloglomerular Feedback ◽  
Diabetic Rat ◽  
Chronic Effects ◽  
Single Nephron ◽  
Sodium Glucose Cotransport ◽  
Acute And Chronic Effects ◽  
Major Reduction

Tubuloglomerular feedback (TGF) stabilizes nephron function from minute to minute and adapts to different steady-state inputs to maintain this capability. Such adaptation inherently renders TGF less efficient at buffering long-term disturbances, but the magnitude of loss is unknown. We undertook the present study to measure the compromise between TGF and TGF adaptation in transition from acute to chronic decline in proximal reabsorption (Jprox). As a tool, we blocked proximal tubule sodium-glucose cotransport with the SGLT2 blocker dapagliflozin in hyperglycemic rats with early streptozotocin diabetes, a condition in which a large fraction of proximal fluid reabsorption owes to SGLT2. Dapagliflozin acutely reduced proximal reabsorption leading to a 70% increase in early distal chloride, a saturated TGF response, and a major reduction in single nephron glomerular filtration rate (SNGFR). Acute and chronic effects on Jprox were indistinguishable. Adaptations to 10–12 days of dapagiflozin included increased reabsorption by Henle's loop, which caused a partial relaxation in the increased tone exerted by TGF that could be explained without desensitization of TGF. In summary, TGF contributes to long-term fluid and salt balance by mediating a persistent decline in SNGFR as the kidney adapts to a sustained decrease in Jprox.

scholarly journals Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine

CNS Spectrums ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 484-494 ◽  
Author(s):  
Yong Kee Choi ◽  
Nika Adham ◽  
Béla Kiss ◽  
István Gyertyán ◽  
Frank I. Tarazi
Keyword(s):  
Ampa Receptors ◽  
Brain Regions ◽  
Receptor Subtypes ◽  
Long Term Effects ◽  
Caudate Putamen ◽  
Chronic Effects ◽  
Hippocampal Ca1 ◽  
Term Administration ◽  
Clinical Benefits

ObjectiveThis study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-HT1Aand 5-HT2A) and glutamate (NMDA and AMPA) receptor subtypes. In addition, the effects of aripiprazole on D2and D3receptors were tested and compared with previously reported cariprazine data.MethodsRats received vehicle, aripiprazole (2, 5, or 15 mg/kg), or cariprazine (0.06, 0.2, or 0.6 mg/kg) for 28 days. Receptor levels were quantified using autoradiographic assays on brain sections from the medial prefrontal cortex (MPC), dorsolateral frontal cortex (DFC), nucleus accumbens (NAc), caudate-putamen medial (CPu–M), caudate-putamen lateral (CPu–L), hippocampal CA1 (HIPP–CA1) and CA3 (HIPP–CA3) regions, and the entorhinal cortex (EC).ResultsSimilar to previous findings with cariprazine, aripiprazole upregulated D2receptor levels in various regions; D3receptor changes were less than those reported with cariprazine. All aripiprazole doses and higher cariprazine doses increased 5-HT1Areceptors in the MPC and DFC. Higher aripiprazole and all cariprazine doses increased 5-HT1Areceptors in HIPP–CA1 and HIPP–CA3. Aripiprazole decreased 5-HT2Areceptors in the MPC, DFC, HIPP–CA1, and HIPP–CA3 regions. Both compounds decreased NMDA receptors and increased AMPA receptors in select brain regions.ConclusionsLong-term administration of aripiprazole and cariprazine had similar effects on 5-HT1A, NMDA, and AMPA receptors. However, cariprazine more profoundly increased D3receptors while aripiprazole selectively reduced 5-HT2Areceptors. These results suggest that the unique actions of cariprazine on dopamine D3receptors, combined with its effects on serotonin and glutamate receptor subtypes, may confer the clinical benefits, safety, and tolerability of this novel compound in schizophrenia and bipolar mania.

Hydrogen sulfide exposure without loss of consciousness: chronic effects in four cases

2002 ◽  
Vol 18 (2) ◽  
pp. 51-61 ◽  
Author(s):  
Alan R Hirsch
Keyword(s):  
Hydrogen Sulfide ◽  
Loss Of Consciousness ◽  
Construction Site ◽  
Long Term Effects ◽  
Chronic Effects ◽  
Low Concentrations ◽  
Clinical Disorders ◽  
Low Levels ◽  
Functional Problems

Adverse effects of acute exposure to hydrogen sulfide (H 2S) are well documented, but long-term effects of occupational exposure to low levels of the gas are not. To evaluate effects of such exposure we performed physical, neurologic, psychiatric, and chemosensory (smell and taste) examinations of four workers who were present but did not lose consciousness when the gas was accidentally released at a construction site. None of the four workers tested positive for functional problems, but all met diagnostic criteria for at least three, and up to eight, H 2S-induced neuropsychiatric clinical disorders and from zero to two subclinical disorders. All four had abnormal P300 evoked responses (electrical neurophysiologic tests of brain waves). Our data indicate that exposures to even relatively low concentrations of H2S are hazardous. A rigorous epidemiologic investigation of persons who work with H2S is warranted.

Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas

1995 ◽  
Vol 133 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Annamaria Colao ◽  
Bartolomeo Merola ◽  
Diego Ferone ◽  
Paolo Marzullo ◽  
Gaetana Cerbone ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenomas ◽  
Acute Administration ◽  
Α Subunit ◽  
Chronic Effects ◽  
Igf I ◽  
Thyroid Axis ◽  
Acute And Chronic Effects ◽  
Non Functioning Pituitary Adenomas

Colao A, Merola B, Ferone D, Marzullo P, Cerbone G, Longobardi S, Di Somma C, Lombardi G. Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. Eur J Endocrinol 1995;133:189–94. ISSN 0804–4643 The effect of somatostatin on thyroid function was studied in 12 patients with growth hormone (GH)-secreting and eight patients with clinically non-functioning adenomas (NFA) and normal pituitary/ thyroid axis; the patients were subjected to the administration of octreotide (OCT), which is a longacting somatostatin analog. All the patients received an acute test with 100 μg of OCT, both short term (1 month) and long term (6 months), with doses ranging from 300 to 600 μg/day, Serum thyroxine (T4). triiodothyronine (T3), free T4, free T3, thyroglobulin and basal and thyrotropin (TSH)-releasing hormone (TRH)-stimulated TSH were evaluated before and after 1 and 6 months of therapy. Circulating GH and insulin-like growth-factor I (IGF-I) in acromegalics and GH, IGF-I and α-subunit in NFA were assessed at baseline and every month. The acute administration of 100 μg of OCT significantly reduced the TSH response to TRH (p < 0.01) in both acromegalics and NFA. In all the patients OCT administration caused a significant decrease of GH, IGF-I and α-subunit levels (p < 0.01). In addition, after 1 month of therapy both baseline and TRH-induced TSH secretion were decreased significantly in acromegalics and NFA. After 6 months of therapy, baseline and TRH-induced TSH was still reduced in NFA. Conversely, in acromegalics, baseline TSH levels were increased while TSH response to TRH was inhibited. No change of T4, T3, free T4 and free T3 was observed in NFA, whereas a slight but significant increase of T4 and decrease of T3 was recorded in acromegalics. In conclusion, OCT does seem to possess long-term suppressive effects on TSH response to TRH, both in acromegalics and NFA. The lack of basal TSH level inhibition in acromegalics could depend on the restored peripheral conversion of T4 into T3 due to the normalized GH levels during long-term OCT administration. Annamaria Colao, Corso Europa 63, 80127 Napoli, Italy

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