Low dose orally administered arginine is able to enhance both basal and growth hormone-releasing hormone-induced growth hormone secretion in normal short children

1993 ◽  
Vol 16 (7) ◽  
pp. 521-525 ◽  
Author(s):  
J. Bellone ◽  
E. Bartolotta ◽  
G. Cardinale ◽  
E. Arvat ◽  
V. Cherubini ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Low Dose ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Short Children

Negative correlation between plasma GHRH values and growth velocity in short prepubertal children

1994 ◽  
Vol 141 (3) ◽  
pp. 541-546
Author(s):  
D Evain-Brion ◽  
D Porquet ◽  
A Fjellestad-Paulsen ◽  
M Donnadieu ◽  
M Noel ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hormone Deficiency ◽  
Growth Hormone Releasing Hormone ◽  
Prepubertal Children ◽  
Releasing Hormone ◽  
Number Of Children ◽  
Short Children

Abstract Numerous data suggest that impaired growth hormone secretion in short children is usually related to abnormal regulation of the hormone at the hypothalamic level. In order to improve our understanding of neurohypothalamic dysfunction in short children, we measured basal and peak (after l–dopa stimulation) plasma growth hormone-releasing hormone levels in 43 prepubertal children. Among them, in 23 children suspected of having hypothalamic growth hormone dysregulation, growth hormone-releasing hormone values were significantly higher than those observed in normal short stature children (n=20), no longer correlated with peak growth hormone following l–dopa, and negatively correlated with growth velocity. This suggests that a predominant inhibitor of growth hormone secretion, such as an increase in somatostatin tone, might be prevalent in a large number of children with partial growth hormone deficiency and suspected hypothalamic growth hormone dysregulation. Journal of Endocrinology (1994) 141, 541–546

Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and l-dopa in obesity

Metabolism ◽  
1990 ◽  
Vol 39 (9) ◽  
pp. 892-896 ◽  
Author(s):  
Katsuaki Tanaka ◽  
Shuji Inoue ◽  
Kazushi Numata ◽  
Hiroshi Okazaki ◽  
Saburo Nakamura ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Weight Reduction ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Hormone ◽  
Very Low Calorie Diet ◽  
Releasing Hormone ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

Stimulation and Inhibition of Growth Hormone Secretion by Interleukin-1β; The Involvement of Growth Hormone-Releasing Hormone

1992 ◽  
Vol 56 (1) ◽  
pp. 118-123 ◽  
Author(s):  
Linda C. Payne ◽  
Ferenc Obal, Jr ◽  
Mark R. Opp ◽  
James M. Krueger
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Interleukin 1Β ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Inhibition Of Growth

Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs

1989 ◽  
Vol 256 (2) ◽  
pp. E221-E226 ◽  
Author(s):  
G. D. Snyder ◽  
P. Yadagiri ◽  
J. R. Falck
Keyword(s):  
Growth Hormone ◽  
Arachidonic Acid ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Epoxyeicosatrienoic Acids ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Growth Hormone Releasing Hormone ◽  
Epoxyeicosatrienoic Acid ◽  
Releasing Hormone

Growth hormone secretion was stimulated in vitro by products of arachidonic acid epoxygenase, the epoxyeicosatrienoic acids. 5,6-Epoxyeicosatrienoic and 14,15-epoxyeicosatrienoic acid stimulated growth hormone release from an enriched population of somatotrophs (approximately 85%) by twofold. Inhibition of arachidonic acid metabolism by indomethacin did not affect growth hormone-releasing hormone stimulation of growth hormone release. In contrast, pretreatment of somatotrophs with an 11,12-isonitrile analogue of arachidonic acid that inhibits arachidonic acid epoxygenase, resulted in a 20-25% inhibition of growth hormone-releasing hormone-stimulated growth hormone release. 14,15-Epoxyeicosatrienoic acid stimulated a concentration-dependent increase (twofold) in the cytoplasmic concentration of adenosine 3',5'-cyclic monophosphate (cAMP) in the somatotrophs. 14,15-Epoxyeicosatrienoic acid also rapidly increased the intracellular free calcium concentration in somatotrophs from resting levels (approximately 80 nM) to greater than 250 nM. Growth hormone-releasing hormone increased the free intracellular calcium to 160-180 nM. Preincubation of somatotrophs with somatostatin inhibited growth hormone-releasing hormone-stimulated growth hormone secretion, cAMP accumulation, and 14,15-epoxyeicosatrienoic acid stimulated cAMP accumulation. These data are suggestive that the epoxyeicosatrienoic acids may have a role in the secretion of growth hormone.

Effect of galanin on growth hormone-releasing hormone-stimulated growth hormone secretion in adult patients with nonendocrine diseases on long-term daily glucocorticoid treatment

Metabolism ◽  
1992 ◽  
Vol 41 (5) ◽  
pp. 548-551 ◽  
Author(s):  
Andrea Giustina ◽  
Angela Girelli ◽  
Simonetta Bossoni ◽  
Fabio Legati ◽  
Maurizio Schettino ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Adult Patients ◽  
Growth Hormone Releasing Hormone ◽  
Glucocorticoid Treatment ◽  
Releasing Hormone

Cholinergic Modulation of Growth Hormone-Releasing Hormone Effects on Growth Hormone Secretion in Dementia

1990 ◽  
Vol 24 (3) ◽  
pp. 129-134 ◽  
Author(s):  
Giovanni Murialdo ◽  
Francesco Zerbi ◽  
Ugo Filippi ◽  
Pietro Tosca ◽  
Stefano Fonzi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Hormone ◽  
Cholinergic Modulation ◽  
Releasing Hormone ◽  
Hormone Effects
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