Structural neuroimaging of Alzheimer’s disease and other dementias

2001 ◽  
Vol 13 (3) ◽  
pp. 203-209 ◽  
Author(s):  
Ph. Scheltens
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structural Neuroimaging

scholarly journals Contributions of a high-fat diet to Alzheimer's disease-related decline: A longitudinal behavioural and structural neuroimaging study in mouse models

2019 ◽  
Vol 21 ◽  
pp. 101606 ◽  
Author(s):  
Colleen P.E. Rollins ◽  
Daniel Gallino ◽  
Vincent Kong ◽  
Gülebru Ayranci ◽  
Gabriel A. Devenyi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
High Fat Diet ◽  
High Fat ◽  
Structural Neuroimaging ◽  
Neuroimaging Study

Contribution of Structural Neuroimaging to the Early Diagnosis of Alzheimer's Disease

1997 ◽  
Vol 9 (S1) ◽  
pp. 183-190 ◽  
Author(s):  
Mony J. de Leon ◽  
Antonio Convit ◽  
Susan DeSanti ◽  
Maciej Bobinski ◽  
Ajax E. George ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hippocampal Formation ◽  
Neuronal Loss ◽  
Hippocampal Volume ◽  
Normal Aging ◽  
Cognitively Impaired ◽  
Structural Neuroimaging ◽  
Neuropsychological Profile ◽  
Neuroimaging Data

There is compelling evidence for the early involvement of the hippocampal formation in the natural history of Alzheimer's disease (AD). The evidence comes from recent neuropathology, neuropsychology, and neuroimaging studies. AD-type histopathologic changes limited to the hippocampus have been described and may be seen in normal aging subjects. The sites of maximal neuronal loss in the hippocampal formation are in the CA1, subiculum, and entorhinal cortex. Minimally cognitively impaired (MCI) individuals (defined by ratings of functional capacity and psychiatric symptomatology) exhibit a neuropsychological profile that is distinct from that of the unimpaired elderly. Pathologic evidence suggests that most of these cases already have AD brain changes accentuated in the hippocampal region, and our own longitudinal studies reveal that 70% of this group develop dementia within a 4-year period. We have developed a negative-angle axial view designed to cut parallel to the anterior-posterior plane of the hippocampus. Using this modified axial plane of section in conjunction with computed tomography (CT) and magnetic resonance imaging (MRI), we estimated the prevalence of hippocampal atrophy in normal aging and across severity levels of cognitively impaired elderly patients. Longitudinal study shows that hippocompal atrophy is a sensitive and specific predictor of future AD for patients with MCI. MRI volume study of AD patients, controls, and MCI patients shows specific hippocampal volume loss in MCI. We conclude that the atrophic changes associated with early AD can be visualized using qualitative techniques and are readily quantifiable with volumetry. This article is not intended to be comprehensive, but to provide an overview of some of the structural neuroimaging data from our laboratory.

Structural Neuroimaging of the Medial Temporal Lobe in Alzheimer’s Disease Clinical Trials

2015 ◽  
Vol 48 (3) ◽  
pp. 581-589 ◽  
Author(s):  
Manuel Menéndez-González ◽  
Benito de Celis Alonso ◽  
José Salas-Pacheco ◽  
Oscar Arias-Carrión
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Structural Neuroimaging

Structural Neuroimaging in Aging and Alzheimer's Disease

2012 ◽  
Vol 22 (1) ◽  
pp. 33-55 ◽  
Author(s):  
Meike W. Vernooij ◽  
Marion Smits
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structural Neuroimaging

scholarly journals Structural Neuroimaging Genetics Interactions in Alzheimer’s Disease

2015 ◽  
Vol 48 (4) ◽  
pp. 1051-1063 ◽  
Author(s):  
Seok Woo Moon ◽  
Ivo D. Dinov ◽  
Jaebum Kim ◽  
Alen Zamanyan ◽  
Sam Hobel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structural Neuroimaging ◽  
Neuroimaging Genetics

Early diagnosis of alzheimer’s disease: contribution of structural neuroimaging

NeuroImage ◽  
2003 ◽  
Vol 18 (2) ◽  
pp. 525-541 ◽  
Author(s):  
G.aël Chetelat ◽  
Jean-Claude Baron
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Structural Neuroimaging
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