scholarly journals Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Regulates the Signaling Mechanism of the Rapid Nongenomic Action of Dexamethasone on Actin Cytoskeleton

1999 ◽  
Vol 5 (11) ◽  
pp. 731-742 ◽  
Author(s):  
Sevasti B. Koukouritaki ◽  
Achille Gravanis ◽  
Christos Stournaras
Keyword(s):  
Actin Cytoskeleton ◽  
Focal Adhesion Kinase ◽  
Tyrosine Phosphorylation ◽  
Focal Adhesion ◽  
Signaling Mechanism ◽  
Nongenomic Action

scholarly journals TNF-α Induces Actin Cytoskeleton Reorganization in Glomerular Epithelial Cells Involving Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase

1999 ◽  
Vol 5 (6) ◽  
pp. 382-392 ◽  
Author(s):  
S. B. Koukouritaki ◽  
E. A. Vardaki ◽  
E. A. Papakonstanti ◽  
E. Lianos ◽  
C. Stournaras ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Actin Cytoskeleton ◽  
Focal Adhesion Kinase ◽  
Tyrosine Phosphorylation ◽  
Focal Adhesion ◽  
Glomerular Epithelial Cells ◽  
Cytoskeleton Reorganization ◽  
Tnf Α

scholarly journals Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide.

1994 ◽  
Vol 269 (41) ◽  
pp. 25247-25250
Author(s):  
C Zhang ◽  
M P Lambert ◽  
C Bunch ◽  
K Barber ◽  
W S Wade ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Tyrosine Phosphorylation ◽  
Nerve Cell ◽  
Cell Lines ◽  
Focal Adhesion ◽  
Beta Peptide

scholarly journals Candida albicans Expresses a Focal Adhesion Kinase-Like Protein That Undergoes Increased Tyrosine Phosphorylation upon Yeast Cell Adhesion to Vitronectin and the EA.hy 926 Human Endothelial Cell Line

2002 ◽  
Vol 70 (7) ◽  
pp. 3804-3815 ◽  
Author(s):  
Giorgio Santoni ◽  
Roberta Lucciarini ◽  
Consuelo Amantini ◽  
Jordan Jacobelli ◽  
Elisabetta Spreghini ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Candida Albicans ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Yeast Cell ◽  
Focal Adhesion Kinase ◽  
Cell Line ◽  
Tyrosine Phosphorylation ◽  
Focal Adhesion ◽  
Human Endothelial Cell Line

ABSTRACT The signaling pathways triggered by adherence of Candida albicans to the host cells or extracellular matrix are poorly understood. We provide here evidence in C. albicans yeasts of a p105 focal adhesion kinase (Fak)-like protein (that we termed CaFak), antigenically related to the vertebrate p125Fak, and its involvement in integrin-like-mediated fungus adhesion to vitronectin (VN) and EA.hy 926 human endothelial cell line. Biochemical analysis with different anti-chicken Fak antibodies identified CaFak as a 105-kDa protein and immunofluorescence and cytofluorimetric analysis on permeabilized cells specifically stain C. albicans yeasts; moreover, confocal microscopy evidences CaFak as a cytosolic protein that colocalizes on the membrane with the integrin-like VN receptors upon yeast adhesion to VN. The protein tyrosine kinase (PTK) inhibitors genistein and herbimycin A strongly inhibited C. albicans yeast adhesion to VN and EA.hy 926 endothelial cells. Moreover, engagement of αvβ3 and αvβ5 integrin-like on C. albicans either by specific monoclonal antibodies or upon adhesion to VN or EA.hy 926 endothelial cells stimulates CaFak tyrosine phosphorylation that is blocked by PTK inhibitor. A role for CaFak in C. albicans yeast adhesion was also supported by the failure of VN to stimulate its tyrosine phosphorylation in a C. albicans mutant showing normal levels of CaFak and VNR-like integrins but displaying reduced adhesiveness to VN and EA.hy 926 endothelial cells. Our results suggest that C. albicans Fak-like protein is involved in the control of yeast cell adhesion to VN and endothelial cells.

Regulation of the Actin Cytoskeleton by p125 Focal Adhesion Kinase in Rat Pancreatic Acinar Cells

Digestion ◽  
1999 ◽  
Vol 60 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Karlheinz Kiehne ◽  
Karl H. Herzig ◽  
Ulrich R. Fölsch
Keyword(s):  
Actin Cytoskeleton ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells
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