Identification of steroid hormone signaling pathway in insect cell differentiation

2007 ◽  
Vol 64 (3) ◽  
pp. 365-376 ◽  
Author(s):  
D. Siaussat ◽  
F. Bozzolan ◽  
P. Porcheron ◽  
S. Debernard
Keyword(s):  
Cell Differentiation ◽  
Signaling Pathway ◽  
Insect Cell ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
Steroid Hormone Signaling

scholarly journals Independent elaboration of steroid hormone signaling pathways in Metazoans

2009 ◽  
Author(s):  
Gabriel Markov ◽  
Raquel Tavares ◽  
Chantal Dauphin-Villemant ◽  
Barbara Demeneix ◽  
Michael Baker ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
Steroid Hormone Signaling

Steroid Hormone Signaling between Schwann Cells and Neurons Regulates the Rate of Myelin Synthesis

2003 ◽  
Vol 1007 (1) ◽  
pp. 340-348 ◽  
Author(s):  
PAUL M. RODRIGUEZ-WAITKUS ◽  
ANDREW J. LAFOLLETTE ◽  
BENJAMIN K. NG ◽  
THANT S. ZHU ◽  
H EDWARD CONRAD ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
Steroid Hormone Signaling

scholarly journals Noncatalytic Role of the FKBP52 Peptidyl-Prolyl Isomerase Domain in the Regulation of Steroid Hormone Signaling

2007 ◽  
Vol 27 (24) ◽  
pp. 8658-8669 ◽  
Author(s):  
Daniel L. Riggs ◽  
Marc B. Cox ◽  
Heather L. Tardif ◽  
Martin Hessling ◽  
Johannes Buchner ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Genetic Selection ◽  
Steroid Hormone Receptors ◽  
Hormone Signaling ◽  
Prolyl Isomerase ◽  
Peptidyl Prolyl Isomerase ◽  
Isomerase Activity ◽  
Steroid Hormone Signaling

ABSTRACT Hormone-dependent transactivation by several of the steroid hormone receptors is potentiated by the Hsp90-associated cochaperone FKBP52, although not by the closely related FKBP51. Here we analyze the mechanisms of potentiation and the functional differences between FKBP51 and FKBP52. While both have peptidyl-prolyl isomerase activity, this is not required for potentiation, as mutations abolishing isomerase activity did not affect potentiation. Genetic selection in Saccharomyces cerevisiae for gain of potentiation activity in a library of randomly mutated FKBP51 genes identified a single residue at position 119 in the N-terminal FK1 domain as being a critical difference between these two proteins. In both the yeast model and mammalian cells, the FKBP51 mutation L119P, which is located in a hairpin loop overhanging the catalytic pocket and introduces the proline found in FKBP52, conferred significant potentiation activity, whereas the converse P119L mutation in FKBP52 decreased potentiation. A second residue in this loop, A116, also influences potentiation levels; in fact, the FKBP51-A116V L119P double mutant potentiated hormone signaling as well as wild-type FKBP52 did. These results suggest that the FK1 domain, and in particular the loop overhanging the catalytic pocket, is critically involved in receptor interactions and receptor activity.

scholarly journals Divergence in Sex Steroid Hormone Signaling between Sympatric Species of Japanese Threespine Stickleback

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e29253 ◽  
Author(s):  
Jun Kitano ◽  
Yui Kawagishi ◽  
Seiichi Mori ◽  
Catherine L. Peichel ◽  
Takashi Makino ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Sympatric Species ◽  
Threespine Stickleback ◽  
Sex Steroid ◽  
Hormone Signaling ◽  
Sex Steroid Hormone ◽  
Steroid Hormone Signaling

MOLECULAR MECHANISMS OF STEROID HORMONE SIGNALING IN PLANTS

2005 ◽  
Vol 21 (1) ◽  
pp. 177-201 ◽  
Author(s):  
Grégory Vert ◽  
Jennifer L. Nemhauser ◽  
Niko Geldner ◽  
Fangxin Hong ◽  
Joanne Chory
Keyword(s):  
Molecular Mechanisms ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
Steroid Hormone Signaling
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