Programmed cell death and clearance of cell corpses in Caenorhabditis elegans

2016 ◽  
Vol 73 (11-12) ◽  
pp. 2221-2236 ◽  
Author(s):  
Xiaochen Wang ◽  
Chonglin Yang
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

Science ◽  
1992 ◽  
Vol 258 (5090) ◽  
pp. 1955-1957 ◽  
Author(s):  
D. Vaux ◽  
I. Weissman ◽  
S. Kim
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death

Post-embryonic development in the ventral cord of Caenorhabditis elegans

1976 ◽  
Vol 275 (938) ◽  
pp. 287-297 ◽  
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Embryonic Development ◽  
Nerve Cells ◽  
Ventral Cord ◽  
Larval Moult ◽  
A Cell

56 nerve cells are added to the ventral cord and associated ganglia of Caenorhabditis elegans at about the time of the first larval moult. These cells are produced by the uniform division of 13 neuroblasts followed by a defined pattern of cell deaths. Comparison with the data in the previous paper suggests that there is a relationship between the ancestry of a cell and its function. The significance of programmed cell death is discussed.

On the nature of undead cells in the nematode Caenorhabditis elegans

1991 ◽  
Vol 331 (1261) ◽  
pp. 263-271 ◽  
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Epithelial Cell ◽  
Programmed Cell Death ◽  
Synaptic Vesicles ◽  
Loss Of Function ◽  
Cell Type ◽  
Nematode Caenorhabditis Elegans ◽  
Characteristic Features ◽  
Morphological Differences

During the course of normal embryonic and post-embryonic development, 131 cells in a Caenorhabditis elegans hermaphrodite undergo programmed cell death. Loss of function mutations in either of the genes ced-3 or ced-4 abolish cell deaths, enabling these ‘undead’ cells to survive and be incorporated into the adult with no obvious deleterious consequences. Ultrastructural reconstructions have shown that undead cells exhibit many differentiated characteristics. Most of the reconstructed cells appeared to be neurons with all the characteristic features associated with such cells, such as processes, synaptic vesicles and presynaptic specializations. However, clear morphological differences were seen among the undead neurons, suggesting a diversity of cell type. One of the reconstructed cells was a rectal epithelial cell, which had displaced its lineal sister that normally functions in this role. Removal of the ability to undergo programmed cell death by mutation therefore reveals a diversity of cryptic differentiated states that are acquired by cells that normally are destined to die.

Non-developmentally programmed cell death in Caenorhabditis elegans

2007 ◽  
Vol 17 (2) ◽  
pp. 122-133 ◽  
Author(s):  
Nikos Kourtis ◽  
Nektarios Tavernarakis
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death

scholarly journals dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates.

1995 ◽  
Vol 14 (18) ◽  
pp. 4434-4441 ◽  
Author(s):  
A. Sugimoto ◽  
R. R. Hozak ◽  
T. Nakashima ◽  
T. Nishimoto ◽  
J. H. Rothman
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Cell Death Suppressor

Two C. elegans genes control the programmed deaths of specific cells in the pharynx

Development ◽  
1991 ◽  
Vol 112 (2) ◽  
pp. 591-603 ◽  
Author(s):  
R.E. Ellis ◽  
H.R. Horvitz
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Nematode Caenorhabditis Elegans ◽  
Genetic Studies ◽  
C Elegans

The genes ces-1 and ces-2 control the decisions of two cells in the nematode Caenorhabditis elegans to undergo programmed cell death. Mutations that cause a gain of ces-1 function or a reduction of ces-2 function prevent these cells, the sisters of the two pharyngeal NSM neurons, from dying. These mutations do not affect most other cell deaths. Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to occur.

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