Life and Death Decisions: ced-9 and Programmed Cell Death in Caenorhabditis elegans

Science ◽  
1995 ◽  
Vol 270 (5238) ◽  
pp. 931-931 ◽  
Author(s):  
M. O. Hengartner
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Life And Death

scholarly journals Differentiating life and death: An inflammatory affair

2018 ◽  
Author(s):  
Dustin Lane
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Death ◽  
Cell Differentiation ◽  
Programmed Cell Death ◽  
Signaling Networks ◽  
Inhibitors Of Apoptosis ◽  
Life And Death ◽  
Cell Death Signaling ◽  
Cycle Dependent

Programmed cell death signaling networks are frequently activated to coordinate the process of cell differentiation, and a variety of apoptotic events can mediate the process. This can include the ligation of death receptors, the activation of downstream caspases, and the induction of chromatin fragmentation, and all of these events can occur without downstream induction of death. Importantly, regulators of programmed cell death also have established roles in mediating differentiation. This review will provide an overview of apoptosis and its regulation by Inhibitors of Apoptosis (IAPs) and Bcl-2 family members. It will then outline the cross-talk between NF-ĸB and apoptotic signaling in the regulation of apoptosis before discussing the function of these regulators in the control of cell differentiation. It will end on a discussion of how a DNA damage-directed, cell cycle-dependent differentiation program may be controlled across multiple passages through cell cycle, and will assert that the failure to properly differentiate is the underlying cause of cancer.

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

Science ◽  
1992 ◽  
Vol 258 (5090) ◽  
pp. 1955-1957 ◽  
Author(s):  
D. Vaux ◽  
I. Weissman ◽  
S. Kim
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death

Post-embryonic development in the ventral cord of Caenorhabditis elegans

1976 ◽  
Vol 275 (938) ◽  
pp. 287-297 ◽  
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Embryonic Development ◽  
Nerve Cells ◽  
Ventral Cord ◽  
Larval Moult ◽  
A Cell

56 nerve cells are added to the ventral cord and associated ganglia of Caenorhabditis elegans at about the time of the first larval moult. These cells are produced by the uniform division of 13 neuroblasts followed by a defined pattern of cell deaths. Comparison with the data in the previous paper suggests that there is a relationship between the ancestry of a cell and its function. The significance of programmed cell death is discussed.

On the nature of undead cells in the nematode Caenorhabditis elegans

1991 ◽  
Vol 331 (1261) ◽  
pp. 263-271 ◽  
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Epithelial Cell ◽  
Programmed Cell Death ◽  
Synaptic Vesicles ◽  
Loss Of Function ◽  
Cell Type ◽  
Nematode Caenorhabditis Elegans ◽  
Characteristic Features ◽  
Morphological Differences

During the course of normal embryonic and post-embryonic development, 131 cells in a Caenorhabditis elegans hermaphrodite undergo programmed cell death. Loss of function mutations in either of the genes ced-3 or ced-4 abolish cell deaths, enabling these ‘undead’ cells to survive and be incorporated into the adult with no obvious deleterious consequences. Ultrastructural reconstructions have shown that undead cells exhibit many differentiated characteristics. Most of the reconstructed cells appeared to be neurons with all the characteristic features associated with such cells, such as processes, synaptic vesicles and presynaptic specializations. However, clear morphological differences were seen among the undead neurons, suggesting a diversity of cell type. One of the reconstructed cells was a rectal epithelial cell, which had displaced its lineal sister that normally functions in this role. Removal of the ability to undergo programmed cell death by mutation therefore reveals a diversity of cryptic differentiated states that are acquired by cells that normally are destined to die.

Non-developmentally programmed cell death in Caenorhabditis elegans

2007 ◽  
Vol 17 (2) ◽  
pp. 122-133 ◽  
Author(s):  
Nikos Kourtis ◽  
Nektarios Tavernarakis
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death

scholarly journals Recherches sur l’auto-initiation de la Mort cellulaire à la fin du XIXe siècle

Gesnerus ◽  
2007 ◽  
Vol 64 (3-4) ◽  
pp. 193-218
Author(s):  
Laurent Cherlonneix
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
19Th Century ◽  
Molecular Level ◽  
Cell Theory ◽  
Life And Death ◽  
Contemporary Research ◽  
Mort Cellulaire ◽  
The One ◽  
The 19Th Century

At the end of the 19th century, research on cell Death in France and Germany was not simply forgotten by contemporary research but in this context it appears that the growing power of cell theory together with an ancient philosophical “superiority” of life over death hijacked more surely the attention of the discoverers – among whom Vogt – of self-initiation of cell Death than the contemporary forgetting of biologists of “programmed” cell Death along with their “incapacity” to read in German. So the work of the Pasteurian Metchnikoff on muscular phagocytosis anticipates on the one hand the equivocity of factors that are disclosed in the framework of recent research. But Metchnikoff did not take advantage of it for theoretical consequences of the duality – normal and pathological – of muscular phagocytosis because this was not his aim.The research by Noetzel in Halle on self-dismantling of tadpole tails during the development does not contradict this perspective. Self-initiation of cell Death towards the end of the 19th century deals with cellular and intracellular levels but it leads to observations done with the microscope and not to inferences at molecular level. The thinness of these older observations is not really contradicted or repeated by contemporary research. It designs a field of observations that has its autonomy in comparison with actual issues on cell Death. On the contrary, the Weismann–Goette debate is closer to today. Behind the opposition of organisms that would be immortals and organisms whose mortality would lie in the necessity to reproduce themselves with the intention to rejuvenate, appears a debate initiated at that time and which now comes to its maturity between Darwinians who support a secondary death and those who support a more equivocal conception where Life and Death associate in depth but still do not mix.

scholarly journals dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates.

1995 ◽  
Vol 14 (18) ◽  
pp. 4434-4441 ◽  
Author(s):  
A. Sugimoto ◽  
R. R. Hozak ◽  
T. Nakashima ◽  
T. Nishimoto ◽  
J. H. Rothman
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Programmed Cell Death ◽  
Cell Death Suppressor
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