This chapter describes an initial region-based formalisation of some concepts about neuroanatomy into ontological and epistemic terms, as part of a major effort into the formalisation of the knowledge contained in neuroimages of patients with schizophrenia. The long-term goal is to build an ontology that is a formal basis for the expectations generated from statistical data analysis. To this end, the chapter presents an example of applying this ontology to interpret the results of image-based analysis of neuroimages from schizophrenic patients.