Effects of irregular cerebrospinal fluid production rate in human brain ventricular system

1. Anaesthetized, nephrectomized rats were infused intravenously with unlabelled angiotensin II (AII) or with [3H]angiotensin II (3H-labelled AII). The brain ventricular system was perfused with artificial cerebrospinal fluid. The perfusate was collected from the cisterna magna and analysed for AII by radioimmunological and biochemical methods. 2. No increase of immunoreactive AII in cerebrospinal fluid could be shown during intravenous infusion of AII. 3. During intravenous infusions of 3H-labelled AII at pressor doses small amounts of radioactivity were found in cerebrospinal fluid perfusate. 4. The radioactivity of cerebrospinal fluid outflow could not be related to AII.

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Variation in supratentorial cerebrospinal fluid production rate in one day: measurement by nontriggered phase-contrast magnetic resonance imaging

Japanese Journal of Radiology ◽

10.1007/s11604-010-0525-y ◽

2011 ◽

Vol 29 (2) ◽

pp. 110-115 ◽

Cited By ~ 4

Author(s):

Hiroto Takahashi ◽

Hisashi Tanaka ◽

Norihiko Fujita ◽

Kenya Murase ◽

Noriyuki Tomiyama

Keyword(s):

Magnetic Resonance Imaging ◽

Cerebrospinal Fluid ◽

Magnetic Resonance ◽

Production Rate ◽

Phase Contrast ◽

Resonance Imaging ◽

Contrast Magnetic Resonance Imaging ◽

Phase Contrast Magnetic Resonance ◽

Contrast Magnetic Resonance ◽

Fluid Production

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Diatrizoate Levels in Cerebrospinal Fluid Following Intravenous Administration Role of Fluid Production Rate

Investigative Radiology ◽

10.1097/00004424-198805000-00009 ◽

1988 ◽

Vol 23 (5) ◽

pp. 377-380 ◽

Cited By ~ 2

Author(s):

PHILLIP P. HARNISH ◽

FRANCES K. NORTHINGTON ◽

KATHIANN A. SAMUEL

Keyword(s):

Cerebrospinal Fluid ◽

Production Rate ◽

Intravenous Administration ◽

Fluid Production

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Automatic Model-guided Segmentation of the Human Brain Ventricular System From CT Images

Academic Radiology ◽

10.1016/j.acra.2010.02.013 ◽

2010 ◽

Vol 17 (6) ◽

pp. 718-726 ◽

Cited By ~ 23

Author(s):

Jimin Liu ◽

Su Huang ◽

Volkau Ihar ◽

Wojciech Ambrosius ◽

Looi Chow Lee ◽

...

Keyword(s):

Human Brain ◽

Ct Images ◽

Ventricular System ◽

Brain Ventricular System

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Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus

Journal of Neurosurgery ◽

10.3171/jns.2002.97.6.1271 ◽

2002 ◽

Vol 97 (6) ◽

pp. 1271-1275 ◽

Cited By ~ 73

Author(s):

Gerald D. Silverberg ◽

Stephen Huhn ◽

Richard A. Jaffe ◽

Steven D. Chang ◽

Thomas Saul ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Production Rate ◽

Ventricular Catheter ◽

Chronic Hydrocephalus ◽

Production Rates ◽

Normal Range ◽

Content Type ◽

Fluid Production ◽

Csf Production ◽

Fine Print

Object. The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus. Methods. The authors studied CSF production both in patients presenting with acute and chronic hydrocephalus, and patients with Parkinson disease (PD) of a similar mean age, whose CSF production was known to be normal. A modification of the Masserman method was used to measure CSF production through a ventricular catheter. The CSF production rates (means ± standard deviations) in the three groups were then compared. The patients with PD had a mean CSF production rate of 0.42 ± 0.13 ml/minute; this value lies within the normal range measured using this technique. Patients with acute hydrocephalus had a similar CSF production rate of 0.4 ± 0.13 ml/minute, whereas patients with chronic hydrocephalus had a significantly decreased mean CSF production rate of 0.25 ± 0.08 ml/minute. Conclusions. The authors postulate that chronic increased intracranial pressure causes downregulation of CSF production.

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Effect of certain drugs on cerebrospinal fluid production in the dog

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1964.206.2.247 ◽

1964 ◽

Vol 206 (2) ◽

pp. 247-250 ◽

Cited By ~ 55

Author(s):

W. W. Oppelt ◽

C. S. Patlak ◽

D. P. Rall

Keyword(s):

Cerebrospinal Fluid ◽

Carbonic Anhydrase ◽

Production Rate ◽

Cardiac Glycoside ◽

Intrathecal Administration ◽

Production Rates ◽

Ventriculocisternal Perfusion ◽

Fluid Production ◽

Significant Change ◽

Csf Production

Cerebrospinal fluid (CSF) production rates were measured in the dog by ventriculocisternal perfusion with inulin containing buffer. Normal CSF production rate was found to be about 0.05 ml/min which represents a turnover of 0.4%/min. After intravenous administration of the carbonic anhydrase inhibitors, acetazolamide and methazolamide, a 40–50% decrease in CSF production occurred. An increase in plasma pCO2, by allowing the animals to inhale 95% oxygen, 5% CO2, did not result in any significant change in CSF production. Both intravenous and intrathecal administration of varying doses of the cardiac glycoside, ouabain, did not cause any significant change in CSF production rates. It is concluded that CSF production, in part, is controlled by a carbonic anhydrase system.

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