Studies on the synthesis, in vitro antitumor activity of 4H-benzo[h]chromene, 7H-benzo[h]chromene[2,3-d]pyrimidine derivatives and structure–activity relationships of the 2-,3- and 2,3-positions

2014 ◽  
Vol 23 (6) ◽  
pp. 3187-3199 ◽  
Author(s):  
Ahmed M. El-Agrody ◽  
Ahmed M. Fouda ◽  
Al-Anood M. Al-Dies
2019 ◽  
Vol 16 (6) ◽  
pp. 462-467
Author(s):  
Songtao Li ◽  
Hongling Zhao ◽  
Zhifeng Yin ◽  
Shuhua Deng ◽  
Yang Gao ◽  
...  

A series of new phenanthrene-based tylophorine derivatives (PBTs) were synthesized in good yield and their structures were characterized by 1H-NMR spectroscopy and ESI MS. In vitro antitumor activity of these compounds against five human carcinoma cell lines, including HCT116 (colorectal), BGC-823 (gastric), HepG-2 (hepatic), Hela (cervical) and H460 (lung) cells, was evaluated by MTT assay. Among these PBTs, compound 6b showed the highest antitumor activities against HCT116 and HepG-2 cell lines with IC50 values of 6.1 and 6.4 μM, respectively, which were comparable to that of adriamycin hydrochloride. The structure-activity relationship of these compounds was also discussed based on the results of their antitumor activity.


2012 ◽  
Vol 22 (6) ◽  
pp. 2212-2215 ◽  
Author(s):  
A. Chris Krueger ◽  
Darold L. Madigan ◽  
David W. Beno ◽  
David A. Betebenner ◽  
Robert Carrick ◽  
...  

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