scholarly journals Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

Diabetologia ◽  
2009 ◽  
Vol 52 (4) ◽  
pp. 626-635 ◽  
Author(s):  
S. Zraika ◽  
R. L. Hull ◽  
J. Udayasankar ◽  
K. Aston-Mourney ◽  
S. L. Subramanian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis ◽  
Amyloid Formation ◽  
Islet Amyloid

Ruthenium complexes as inhibitors of human islet amyloid polypeptide aggregation, an effect that prevents beta cell apoptosis

RSC Advances ◽  
2015 ◽  
Vol 5 (23) ◽  
pp. 17405-17412 ◽  
Author(s):  
Lijuan Ma ◽  
Yuanting Fu ◽  
Lianling Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Apoptosis ◽  
Cell Damage ◽  
Islet Amyloid Polypeptide ◽  
Ruthenium Complexes ◽  
Human Islet ◽  
Ros Generation ◽  
Beta Cell Apoptosis ◽  
Islet Amyloid ◽  
Application Potential

Herein we show that ruthenium complexes could inhibit fibrosis of hIAPP and protect the hIAPP-induced cell damage by suppressing ROS generation, indicating the application potential of the complexes in treatment of T2DM by targeting hIAPP.

Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis

2015 ◽  
Vol 59 (4) ◽  
pp. 820-824 ◽  
Author(s):  
Elisa Fernández-Millán ◽  
Isabel Cordero-Herrera ◽  
Sonia Ramos ◽  
Fernando Escrivá ◽  
Carmen Alvarez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Mass Loss ◽  
Cell Apoptosis ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Beta Cell Apoptosis ◽  
Zucker Diabetic Fatty Rats ◽  
And Function

GDF15 Is Induced by T1D-Associated Cytokines and ER Stress and Promotes Beta-Cell Apoptosis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2109-P ◽  
Author(s):  
GUANLAN XU ◽  
LANCE THIELEN ◽  
JUNQIN CHEN ◽  
SEONGHO JO ◽  
ANATH SHALEV
Keyword(s):  
Beta Cell ◽  
Er Stress ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis

Diabetes ◽  
2001 ◽  
Vol 50 (Supplement 1) ◽  
pp. S70-S76 ◽  
Author(s):  
S. V. Zaitsev ◽  
I. B. Appelskog ◽  
I. L. Kapelioukh ◽  
S. Yang ◽  
M. K hler ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis ◽  
Interleukin 1Beta ◽  
Imidazoline Compounds
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