scholarly journals An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

Diabetologia ◽  
2009 ◽  
Vol 53 (1) ◽  
pp. 144-152 ◽  
Author(s):  
A. Tura ◽  
S. Sbrignadello ◽  
E. Succurro ◽  
L. Groop ◽  
G. Sesti ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Clinical Characteristics ◽  
Glucose Clamp

scholarly journals Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans

2000 ◽  
Vol 85 (7) ◽  
pp. 2402-2410 ◽  
Author(s):  
Arie Katz ◽  
Sridhar S. Nambi ◽  
Kieren Mather ◽  
Alain D. Baron ◽  
Dean A. Follmann ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Accurate Method ◽  
Model Analysis ◽  
Glucose Clamp ◽  
Clinical Investigations ◽  
Glucose Tolerance Tests ◽  
Type 2 Diabetic

Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and minimal model analysis are two established methods for determining insulin sensitivity in vivo, but neither is easily implemented in large studies. Thus, it is of interest to develop a simple, accurate method for assessing insulin sensitivity that is useful for clinical investigations. We performed both hyperinsulinemic isoglycemic glucose clamp and insulin-modified frequently sampled iv glucose tolerance tests on 28 non-obese, 13 obese, and 15 type 2 diabetic subjects. We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SIClamp) and minimal model analysis (SIMM) that were comparable to previous reports (r = 0.57). We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e. fasting insulin (I0) and glucose (G0)] contain critical information about insulin sensitivity. We defined a quantitative insulin sensitivity check index (QUICKI = 1/[log(I0) + log(G0)]) that has substantially better correlation with SIClamp (r = 0.78) than the correlation we observed between SIMM and SIClamp. Moreover, we observed a comparable overall correlation between QUICKI and SIClamp in a totally independent group of 21 obese and 14 nonobese subjects from another institution. We conclude that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.

A Minimal-Model-Based Glucose Clamp Yielding Insulin Sensitivity Independent of Glycemia

Diabetes ◽  
1982 ◽  
Vol 31 (5) ◽  
pp. 432-441 ◽  
Author(s):  
G. Pacini ◽  
D. T. Finegood ◽  
R. N. Bergman
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Glucose Clamp ◽  
Model Based

A minimal-model-based glucose clamp yielding insulin sensitivity independent of glycemia

Diabetes ◽  
1982 ◽  
Vol 31 (5) ◽  
pp. 432-441 ◽  
Author(s):  
G. Pacini ◽  
D. T. Finegood ◽  
R. N. Bergman
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Glucose Clamp ◽  
Model Based

QUICKI is a useful index of insulin sensitivity in subjects with hypertension

2003 ◽  
Vol 284 (4) ◽  
pp. E804-E812 ◽  
Author(s):  
Hui Chen ◽  
Gail Sullivan ◽  
Lilly Q. Yue ◽  
Arie Katz ◽  
Michael J. Quon
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Minimal Model ◽  
Fasting Blood Glucose ◽  
Glucose Clamp ◽  
Model Assessment ◽  
Antihypertensive Medications ◽  
Intravenous Glucose ◽  
Glucose Tolerance Tests ◽  
Intravenous Glucose Tolerance Tests

Insulin resistance may link disorders of metabolic homeostasis such as diabetes and obesity with disorders of hemodynamic homeostasis such as hypertension. Thus it is of interest to validate simple methods for quantifying insulin sensitivity in hypertensive patients. The quantitative insulin-sensitivity check index (QUICKI) is a novel mathematical transformation of fasting blood glucose and insulin levels. In obese and diabetic subjects, QUICKI has a significantly better linear correlation with glucose clamp determinations of insulin sensitivity than minimal-model estimates. To determine whether QUICKI is also useful in hypertensive subjects, we performed glucose clamps and frequently sampled intravenous glucose tolerance tests (FSIVGTT) on 27 hypertensive subjects taken off antihypertensive medication. Indexes of insulin sensitivity derived from glucose clamp studies (SIClamp) were compared with QUICKI, minimal-model analysis of FSIVGTTs (SIMM), and homeostasis model assessment (HOMA). The correlation between QUICKI and SIClamp ( r = 0.84) was significantly better than that between SIMM and SIClamp( r = 0.65; P < 0.028). The correlation between QUICKI and SIClamp was comparable to that between 1/HOMA and SIClamp ( r = 0.82). When studies were repeated in 14 subjects who had resumed antihypertensive medications, the percent changes in SIClamp for each of these patients were significantly correlated with percent changes in QUICKI ( r = 0.61) and HOMA ( r = −0.54) but not SIMM ( r = −0.18). We conclude that QUICKI is a simple, robust index of insulin sensitivity that is useful for evaluating and following the insulin resistance of hypertensive subjects in both research studies and clinical practice.

A Comparison Between the Minimal Model and the Glucose Clamp in the Assessment of Insulin Sensitivity Across the Spectrum of Glucose Tolerance

Diabetes ◽  
1994 ◽  
Vol 43 (9) ◽  
pp. 1114-1121 ◽  
Author(s):  
M. F. Saad ◽  
R. L. Anderson ◽  
A. Laws ◽  
R. M. Watanabe ◽  
W. W. Kades ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Minimal Model ◽  
Glucose Clamp

Reduced sampling protocols in estimation of insulin sensitivity and glucose effectiveness using the minimal model in NIDDM

Diabetes ◽  
1993 ◽  
Vol 42 (11) ◽  
pp. 1635-1641 ◽  
Author(s):  
P. A. Coates ◽  
R. L. Ollerton ◽  
S. D. Luzio ◽  
I. S. Ismail ◽  
D. R. Owens
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Glucose Effectiveness ◽  
Sampling Protocols
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