scholarly journals Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

1987 ◽  
Vol 79 (3) ◽  
pp. 790-800 ◽  
Author(s):  
R N Bergman ◽  
R Prager ◽  
A Volund ◽  
J M Olefsky
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Glucose Clamp ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Model Method

Basal plasma insulin and homeostasis model assessment (HOMA) are indicators of insulin sensitivity in cats

2005 ◽  
Vol 7 (3) ◽  
pp. 183-193 ◽  
Author(s):  
DJ Appleton ◽  
JS Rand ◽  
GD Sunvold
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Minimal Model ◽  
Plasma Insulin ◽  
Sensitivity Index ◽  
Model Assessment ◽  
Insulin Sensitivity Index ◽  
Homeostasis Model Assessment ◽  
Body Weights ◽  
Basal Plasma

The objective of this study was to compare simpler indices of insulin sensitivity with the minimal model-derived insulin sensitivity index to identify a simple and reliable alternative method for assessing insulin sensitivity in cats. In addition, we aimed to determine whether this simpler measure or measures showed consistency of association across differing body weights and glucose tolerance levels. Data from glucose tolerance and insulin sensitivity tests performed in 32 cats with varying body weights (underweight to obese), including seven cats with impaired glucose tolerance, were used to assess the relationship between Bergman's minimal model-derived insulin sensitivity index ( SI), and various simpler measures of insulin sensitivity. The most useful overall predictors of insulin sensitivity were basal plasma insulin concentrations and the homeostasis model assessment (HOMA), which is the product of basal glucose and insulin concentrations divided by 22.5. It is concluded that measurement of plasma insulin concentrations in cats with food withheld for 24 h, in conjunction with HOMA, could be used in clinical research projects and by practicing veterinarians to screen for reduced insulin sensitivity in cats. Such cats may be at increased risk of developing impaired glucose tolerance and type 2 diabetes mellitus. Early detection of these cats would enable preventative intervention programs such as weight reduction, increased physical activity and dietary modifications to be instigated.

scholarly journals Minimal Model–Derived Insulin Sensitivity Index Underestimates Insulin Sensitivity in Black Americans

Diabetes Care ◽  
2021 ◽  
pp. dc210490
Author(s):  
Andin Fosam ◽  
Susan Yuditskaya ◽  
Camila Sarcone ◽  
Shivraj Grewal ◽  
Hubert Fan ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Minimal Model ◽  
Black Americans ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index

scholarly journals Postprandial glucose fluxes and insulin sensitivity during exercise: A study in healthy individuals

2013 ◽  
Vol 305 (4) ◽  
pp. E557-E566 ◽  
Author(s):  
Michele Schiavon ◽  
Ling Hinshaw ◽  
Ashwini Mallad ◽  
Chiara Dalla Man ◽  
Giovanni Sparacino ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Healthy Subjects ◽  
Acute Exercise ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Fat Free Mass ◽  
Glucose Turnover ◽  
Sensitivity Index ◽  
Moderate Exercise ◽  
Insulin Sensitivity Index

Quantifying the effect size of acute exercise on insulin sensitivity (SIexercise) and simultaneous measurement of glucose disappearance (Rd), endogenous glucose production (EGP), and meal glucose appearance in the postprandial state has not been developed in humans. To do so, we studied 12 healthy subjects [5 men, age 37.1 ± 3.1 yr, body mass index 24.1 ± 1.1 kg/m2, fat-free mass (FFM) 50.9 ± 3.9 kg] during moderate exercise at 50% V̇o2max for 75 min, 120–195 min after a triple-tracer mixed meal consumed at time 0. Tracer infusion rates were adjusted to achieve constant tracer-to-tracee ratio and minimize non-steady-state errors. Glucose turnover was estimated by accounting for the nonstationary kinetics introduced by exercise. Insulin sensitivity index was calculated in each subject both in the absence [time ( t) = 0–120 min, SIrest] and presence ( t = 0–360 min, SIexercise) of physical activity. EGP at t = 0 min (13.4 ± 1.1 μM·kg FFM−1·min−1) fell at t = 120 min (2.4 ± 0.4 μM·kg FFM−1·min−1) and then rapidly rose almost eightfold at t = 180 min (18.2 ± 2.6 μM·kg FFM−1·min−1) before gradually falling at t = 360 min (10.6 ± 0.9 μM·kg FFM−1·min−1). Rd rapidly peaked at t = 120 min at the start of exercise (89.5 ± 11.6 μM·kg FFM−1·min−1) and then gradually declined at t = 195 min (26.4 ± 3.3 μM·kg FFM−1·min−1) before returning to baseline at t = 360 min. SIexercise was significantly higher than SIrest (21.6 ± 3.7 vs. 12.5 ± 2.0 10−4 dl·kg−1·min−1 per μU/ml, P < 0.0005). Glucose turnover was estimated for the first time during exercise with the triple-tracer technique. Our results, applying state-of-the-art techniques, show that moderate exercise almost doubles postprandial insulin sensitivity index in healthy subjects.

scholarly journals Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Diabetes ◽  
2016 ◽  
Vol 65 (10) ◽  
pp. 3200-3211 ◽  
Author(s):  
Geoffrey A. Walford ◽  
Stefan Gustafsson ◽  
Denis Rybin ◽  
Alena Stančáková ◽  
Han Chen ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Genome Wide

scholarly journals The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study

Diabetologia ◽  
2020 ◽  
Vol 63 (11) ◽  
pp. 2315-2328 ◽  
Author(s):  
Anouk F. J. Geraets ◽  
Sebastian Köhler ◽  
Rutendo Muzambi ◽  
Casper G. Schalkwijk ◽  
Anke Oenema ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Depressive Symptoms ◽  
Insulin Sensitivity ◽  
Cox Regression ◽  
Temporal Association ◽  
Sensitivity Index ◽  
Skin Autofluorescence ◽  
Insulin Sensitivity Index ◽  
Increased Risk

Abstract Aims/hypothesis Depression is twice as common in individuals with type 2 diabetes as in the general population. However, it remains unclear whether hyperglycaemia and insulin resistance are directly involved in the aetiology of depression. Therefore, we investigated the association of markers of hyperglycaemia and insulin resistance, measured as continuous variables, with incident depressive symptoms over 4 years of follow-up. Methods We used data from the longitudinal population-based Maastricht Study (n = 2848; mean age 59.9 ± 8.1 years, 48.8% women, 265 incident depression cases, 10,932 person-years of follow-up). We assessed hyperglycaemia by fasting and 2 h post-load OGTT glucose levels, HbA1c and skin autofluorescence (reflecting AGEs) at baseline. We used the Matsuda insulin sensitivity index and HOMA-IR to calculate insulin resistance at baseline. Depressive symptoms (nine-item Patient Health Questionnaire score ≥10) were assessed at baseline and annually over 4 years. We used Cox regression analyses, and adjusted for demographic, cardiovascular and lifestyle risk factors. Results Fasting plasma glucose, 2 h post-load glucose and HbA1c levels were associated with an increased risk for incident depressive symptoms after full adjustment (HR 1.20 [95% CI 1.08, 1.33]; HR 1.25 [1.08, 1.44]; and HR 1.22 [1.09, 1.37] per SD, respectively), while skin autofluorescence, insulin sensitivity index and HOMA-IR were not (HR 0.99 [0.86, 1.13]; HR 1.02 [0.85, 1.25]; and HR 0.93 [0.81, 1.08], per SD, respectively). Conclusions/interpretation The observed temporal association between hyperglycaemia and incident depressive symptoms in this study supports the presence of a mechanistic link between hyperglycaemia and the development of depressive symptoms.

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