Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes

Abstract Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive. Objective: In this study, we assessed the heritability of mtDNA content in buccal cells and analyzed the association of mtDNA content in blood with prevalent and incident T2D. Design and Setting: mtDNA content from cells from buccal and blood samples was assessed using a real-time PCR-based assay. Heritability of mtDNA content was estimated in 391 twins from the Netherlands Twin Register. The association with prevalent T2D was tested in a case control study from The Netherlands (n = 329). Incident T2D was analyzed using prospective samples from Finland (n = 444) and The Netherlands (n = 238). Main Outcome Measures: We measured the heritability of mtDNA content and the association of mtDNA content in blood with prevalent and incident T2D. Results: A heritability of mtDNA content of 35% (19–48%) was estimated in the twin families. We did not observe evidence of an association between mtDNA content and prevalent or incident T2D and related traits. Furthermore, we observed a decline in mtDNA content with increasing age that was male specific (P = 0.001). Conclusion: In this study, we show that mtDNA content has a heritability of 35% in Dutch twins. There is no association between mtDNA content in blood and prevalent or incident T2D and related traits in our study samples.

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Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Diabetologia ◽

10.1007/s00125-009-1602-6 ◽

2009 ◽

Vol 53 (2) ◽

pp. 247-253 ◽

Cited By ~ 26

Author(s):

A. Gautier ◽

◽

B. Balkau ◽

C. Lange ◽

J. Tichet ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Epidemiological Study ◽

Insulin Resistance Syndrome ◽

Incident Type ◽

Incident Type 2 Diabetes

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Epidemiological support for the protection of whole grains against diabetes

Proceedings of The Nutrition Society ◽

10.1079/pns2002223 ◽

2003 ◽

Vol 62 (1) ◽

pp. 143-149 ◽

Cited By ~ 95

Author(s):

Maureen A. Murtaugh ◽

David R. Jacobs ◽

Brenda Jacob ◽

Lyn M. Steffen ◽

Leonard Marquart

Keyword(s):

Type 2 Diabetes ◽

Glucose Control ◽

Whole Grains ◽

Overweight And Obesity ◽

Whole Grain ◽

Incident Type ◽

Fibre Intake ◽

Incident Type 2 Diabetes ◽

Grain Foods

The epidemic of type 2 diabetes among children, adolescents and adults is increasing along with the increasing prevalence of overweight and obesity. Overweight is the most powerful modifiable risk factor for type 2 diabetes. Intake of whole-grain foods may reduce diabetes risk. Three prospective studies in 160 000 men and women examined the relationship of whole-grain or cereal-fibre intake with the risk of type 2 diabetes. Each study used a mailed Willett food-frequency questionnaire and similar methods of quantifying whole-grain foods and cereal fibre. The self-reported incident diabetes outcome was more reliably determined in the two studies of health-care professionals than in the study of Iowa women. Risk for incident type 2 diabetes was 21–27% lower for those in the highest quintile of whole-grain intake, and 30–36% lower in the highest quintile of cereal-fibre intake, each compared with the lowest quintile. Risk reduction persisted after adjustment for the healthier lifestyle found among habitual whole-grain consumers. Observations in non-diabetic individuals support an inverse relationship between whole-grain consumption and fasting insulin levels. In feeding studies in non-diabetic individuals insulin resistance was reduced using whole grains or diets rich in whole grains. Glucose control improved with diets rich in whole grains in feeding studies of subjects with type 2 diabetes. There is accumulating evidence to support the hypothesis that whole-grain consumption is associated with a reduced risk of incident type 2 diabetes; it may also improve glucose control in diabetic individuals.

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Dietary fibre intake and risk of type 2 diabetes in British women

Proceedings of The Nutrition Society ◽

10.1017/s0029665113002292 ◽

2013 ◽

Vol 72 (OCE4) ◽

Author(s):

M. Aldwairji ◽

C. Orfila ◽

V. J. Burley

Keyword(s):

Type 2 Diabetes ◽

Dietary Fibre ◽

Fibre Intake ◽

Dietary Fibre Intake

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ASSOCIATION BETWEEN KNOWLEDGE, ATTITUDE, AND PRACTICE ABOUT DIETARY FIBRE INTAKE AND TYPE 2 DIABETES AMONG RURAL PEOPLE IN TERENGGANU, MALAYSIA

Malaysian Journal of Public Health Medicine ◽

10.37268/mjphm/vol.21/no.2/art.1039 ◽

2021 ◽

Vol 21 (2) ◽

pp. 338-347

Author(s):

San San Oo ◽

Myat Moe Thwe Aung ◽

CHARAN KISHOR SHETTY ◽

Mohd Salami Ibrahim ◽

Nyi Nyi Naing ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Dietary Fibre ◽

Rural People ◽

Fibre Intake ◽

Attitude And Practice ◽

History Of ◽

Dietary Fibre Intake ◽

Knowledge Attitude And Practice

Awareness of the dietary fibre intake (DF) and its importance in prevention and management of type 2 diabetes mellitus (T2DM) among rural people is seldom reported in Malaysia. This study aimed to determine the knowledge, attitude, and practice (KAP) of DF intake and their association with type 2 diabetes mellitus (T2DM) among rural people in Terengganu, Malaysia. A community-based cross-sectional study was carried out among the households in Kampung Jati, Kuala Nerus, Terengganu, Malaysia from 29th December 2019 until 20th February 2020. The village has 524 houses, the data was collected from all available and eligible subjects in each household by completed socio-demographic, validated KAP on DF intake questionnaire, as well as a 24-hour dietary recall using a self-administered questionnaire. In our study of 396 respondents, 208 (52.5%) were men. The mean age of participants was 37.85 (15.13). Most of the subjects were Malay 384 (97.0%), employed 207 (52.3%) and 274 (69.2%) attained high level of education (from tertiary school level). However, only 170 (42.9%) had a high family income which was of >RM 3860 per month. Out of 396 respondents, 157 (39.6%) of them had family history of diabetes mellitus. Respondents had moderate knowledge (39.1%), positive attitude (88.1%) and good practice (59.3%) scores towards DF intake. Among the respondents, only 39.1% of total respondents knew the nationally recommended amount of daily fibre intake which is of 20-30 grams per day. With multivariable analysis using multiple logistic regression, the analysis results revealed that age (adjusted OR: 1.11, 95% CI: 1.08, 1.15; p <0.001), having family history of T2DM (adjusted OR: 6.81, 95% CI: 2.75, 16.84; p <0.001) and having total attitude scores (adjusted OR: 0.84, 95% CI: 0.76, 0.93; p <0.001) were found to be adjusted significant associated factors of T2DM among the respondents after controlling confounders. Public health authorities should raise awareness on health benefit of consuming dietary fibre to promote an increase in consumption which can help in prevention and management of chronic diseases among rural population of Malaysia.

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