Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

Diabetologia ◽

10.1007/s001250051138 ◽

1999 ◽

Vol 42 (2) ◽

pp. 188-194 ◽

Author(s):

X. Hou ◽

Z. Ling ◽

E. Quartier ◽

A. Foriers ◽

F. Schuit ◽

...

Keyword(s):

Pancreatic Beta Cells ◽

Prolonged Exposure ◽

Islet Amyloid Polypeptide ◽

Islet Amyloid ◽

Cellular Content

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Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2009.01.002 ◽

2009 ◽

Vol 41 (7) ◽

pp. 1526-1535 ◽

Author(s):

Xiao-Ling Li ◽

Gang Xu ◽

Tianfeng Chen ◽

Yum-Shing Wong ◽

Hai-Lu Zhao ◽

...

Keyword(s):

Oxidative Stress ◽

Protein Kinase ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Mitogen Activated Protein Kinase ◽

Islet Amyloid ◽

Mitogen Activated Protein ◽

Induced Apoptosis

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Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2010.12.008 ◽

2011 ◽

Vol 43 (4) ◽

pp. 525-534 ◽

Author(s):

Xiao-Ling Li ◽

Tianfeng Chen ◽

Yum-Shing Wong ◽

Gang Xu ◽

Rong-Rong Fan ◽

...

Keyword(s):

Mitochondrial Dysfunction ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Induced Apoptosis

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Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells

Regulatory Peptides ◽

10.1016/j.regpep.2010.07.115 ◽

2010 ◽

Vol 164 (1) ◽

pp. 44

Author(s):

K. Hunter ◽

Y.H.A. Abdel-Wahab ◽

F.P.M. O'Harte ◽

P.R. Flatt

Keyword(s):

Insulin Secretion ◽

Pancreatic Beta Cells ◽

Inhibitory Action ◽

Islet Amyloid Polypeptide ◽

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Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

Diabetologia ◽

10.1007/s00125-008-1111-z ◽

2008 ◽

Vol 51 (12) ◽

pp. 2252-2262 ◽

Author(s):

S. Casas ◽

A. Novials ◽

F. Reimann ◽

R. Gomis ◽

F. M. Gribble

Keyword(s):

Ion Channel ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Mechanosensitive Ion Channel ◽

Calcium Elevation

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Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

Diabetes Obesity and Metabolism ◽

10.1111/j.1463-1326.2010.01238.x ◽

2010 ◽

Vol 12 (9) ◽

pp. 815-824 ◽

Author(s):

R. Fan ◽

X. Li ◽

X. Gu ◽

J. C. N. Chan ◽

G. Xu

Keyword(s):

Pancreatic Beta Cells ◽

Cell Damage ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Damage Potential ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Mitochondria Biogenesis

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Selenium-enriched Spirulina protects INS-1E pancreatic beta cells from human islet amyloid polypeptide-induced apoptosis through suppression of ROS-mediated mitochondrial dysfunction and PI3/AKT pathway

European Journal of Nutrition ◽

10.1007/s00394-014-0732-x ◽

2014 ◽

Vol 54 (4) ◽

pp. 509-522 ◽

Author(s):

Xiao-Ling Li ◽

Yum-Shing Wong ◽

Gang Xu ◽

Juliana C. N. Chan

Keyword(s):

Mitochondrial Dysfunction ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Akt Pathway ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Induced Apoptosis

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Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

Diabetes ◽

10.2337/diabetes.39.5.634 ◽

1990 ◽

Vol 39 (5) ◽

pp. 634-638 ◽

Author(s):

S. E. Kahn ◽

D. A. D'Alessio ◽

M. W. Schwartz ◽

W. Y. Fujimoto ◽

J. W. Ensinck ◽

...

Keyword(s):

Islet Amyloid Polypeptide ◽

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Strong Promoter Activity of Human and Rat Islet Amyloid Polypeptide / Amylin Gene Constructs in Mouse Beta Cells (βTC 3)

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1993.1491 ◽

1993 ◽

Vol 192 (2) ◽

pp. 840-848 ◽

Author(s):

L. Dewit ◽

A.D.M. Vanmansfeld ◽

H.A.A.M. Vanteeffelen ◽

C.J.M. Lips ◽

J.W.M. Hoppener

Keyword(s):

Promoter Activity ◽

Islet Amyloid Polypeptide ◽

Islet Amyloid ◽

Strong Promoter ◽

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Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptideand protects pancreatic beta-cells against cytotoxicity

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.24216 ◽

2012 ◽

Vol 81 (4) ◽

pp. 613-621 ◽

Author(s):

Biao Cheng ◽

Hao Gong ◽

Xiaochao Li ◽

Yue Sun ◽

Hong Chen ◽

...

Keyword(s):

Pancreatic Beta Cells ◽

Human Islet ◽

Salvianolic Acid B ◽

Amyloid Formation ◽

Islet Amyloid ◽

Salvianolic Acid

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Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets

Diabetologia ◽

10.1007/s00125-006-0206-7 ◽

2006 ◽

Vol 49 (6) ◽

pp. 1237-1246 ◽

Author(s):

J. F. Paulsson ◽

A. Andersson ◽

P. Westermark ◽

G. T. Westermark

Keyword(s):

Transgenic Mice ◽

Islet Amyloid Polypeptide ◽

Human Islets ◽

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