Disease Modification in Gout: A Qualitative Study of Gout Expert Rheumatologists

Objective To examine healthcare provider views of disease modification in gout to potentially derive a provisional set of domains for disease modification in gout. Methods We performed a qualitative nominal group (NG) study with 20 gout experts (15 were authors/expert panel members of the 2012 and/or 2020 ACR gout guidelines, and/or 2015 ACR/EULAR gout classification criteria) about what constitutes “disease modification” in gout – “What sorts of things do you think constitute a change in the course of disease in gout? (positive); What are all the ways in which gout as a disease can be modified?” Results Decrease in gout flares was rated #1 rank in all six NGs as indicative of disease modification in gout, followed by serum urate (SU) lowering, which was rated #1 rank in 1 of the 6 NGs (tied score with flares in one NG). Other components of gout disease modification were to improve quality of life/productivity; restore function; reduce/eliminate pain; reduce tophi burden; and joint preservation or resolution of joint damage. Potential additional components that were not ranked in the top 3 votes within each NG were: Decrease healthcare cost/utilization; cardiovascular/renal morbidity/mortality reduction; and stop urate crystals formation. Conclusion This qualitative study provides a provisional set of domains for disease modification in gout. Future studies for the development of thresholds for disease modification domains, and wider consensus on this definition are needed.

Estimation of the Seismic Damage Potential of RC Frames Using Seismic Parameters

Variation of the fundamental period is regarded as one of the methods to assess the damage of the structures under earthquakes. The inter-relationship among seismic parameters and variation of the fundamental period can identify the potential structural damage of an earthquake. For this purpose, the present paper aimed to study the relations among main seismic parameters, incorporating a variety of information about ground motion and variation of fundamental period. Three RC frames were analyzed under far-fault earthquake records by nonlinear dynamic analyses and mathematical methods applied to assay the correlation between seismic parameters and variation of fundamental period. Based on the results, high correlations were observed between some seismic parameters and variation of fundamental period. Further, based on regression equations, new parameters with a very strong correlation with variations of fundamental periods were achieved, which can be regarded as appropriate indices to estimate the potential structural damage of an earthquake.

Incidence, Abundance and Damage of Papaya Mealybug In Southern Part of Bangladesh And Its Management

The papaya mealybug, Paracoccus marginatus Williams and Granara de Willink, is a small hemipteran that attacks several genera of host plants, including economically important tropical fruits and ornamentals. A study was carried out at farmers’ papaya garden and homestead areas of 8 locations viz., Dumki, Bouphal, Dashmina, Patuakhali, Mirjagonj, Amtali, Kalapara and Kuakata of Patuakhali and Barguna districts of Bangladesh to observe the incidence, abundance, and damage potential of papaya mealybug, Paracoccus marginatus (Williams and Granara de Willink) from March to June 2019. An experiment consisting of seven treatments following randomized complete block design (RCBD) with three replications was conducted for controlling papaya mealybugs at Patuakhali Science and Technology University (PSTU) campus during March to June 2019. Results revealed that among 8 locations, the highest incidence of P. marginatus was recorded in June, and the lowest was in April. The maximum abundance of P. marginatus on leaves and fruits of the papaya plant was observed at Kolapara, and the lowest was at Amtali. The highest percent infested plants (65%) per location, infested leaves/plant (97%), and infested fruits/plant (47%) was recorded in Kolapara, and the lowest percent infestations (31, 18, and 11%, respectively) were in Amtali. Among all treatments, the removal of infested leaves with petioles and application of Nitro 505EC @ 1 ml/L of water (T1) was the best approach for the management of papaya mealybugs. The removal of infested leaves with petioles + Biotap plus extra 95EC @ 0.2 g/L of water (T3) could be used as 2nd choice for controlling papaya mealybugs. The results concluded that removal of infested leaves and the application of Nitro 505 EC at the rate of 1 ml/L of water might be used to control the papaya mealybug. J. Asiat. Soc. Bangladesh, Sci. 47(2): 109-120, December 2021

Design and Numerical Analysis of Electric Vehicle Li-Ion Battery Protections Using Lattice Structure Undergoing Ground Impact

Improvement in electric vehicle technology requires the lithium-ion battery system’s safe operations, protecting battery fire damage potential from road debris impact. In this research a design of sandwich panel construction with a lattice structure core is evaluated as the battery protection system. Additive manufacturing technology advancements have paved the way for lattice structure development. The sandwich protective structure designs are evaluated computationally using a non-linear dynamic finite element analysis for various geometry and material parameters. The lattice structure’s optimum shape was obtained based on the highest Specific Energy Absorption (SEA) parameter developed using the ANOVA and Taguchi robust design method. It is found that the octet-cross lattice structure with 40% relative density provided the best performance in terms of absorbing impact energy. Furthermore, the sandwich panel construction with two layers of lattice structure core performed very well in protecting the lithium-ion NCA battery in the ground impact loading conditions, which the impactor velocity is 42 m/s, representing vehicle velocity in highway, and weigh 0.77 kg. The battery shortening met the safety threshold of less than 3 mm deformation.

An Innovative Acid Diversion Using In-Situ Foam Generation: Experimental and Successful Field Application

In carbonate reservoirs, effective acid stimulation is essential to overcome reservoir damage and mainline high oil production. Recently, most of oil wells are being drilled horizontally to maximize production. Acid stimulation of horizontal wells with long intervals require very effective acid diversion system. If the diversion system is not efficient enough, most of the acid will be leaking-off near the casing shoe, in openhole well, which will result in a fast water breakthrough and diminish production. This study describes a breakthrough treatment for acidizing long horizontal wells in carbonate formations. The novel technology is based on in-situ foam generation to divert the acid. Gas diversion, as a foam, is a perfect diversion mechanism as gas creates pressure resistance which forces the acid stages to be diverted to new ones?. The diversion will not require the acid to be spent, compared to viscoelastic diverting system. Moreover, no gel is left behind post treatment, which will eliminate any damage potential. The system is not impacted with the presence of corrosion products, where diverting system will not function without effective pickling and tubular cleanup. Lab results showed that the new in-situ foam generation system was very effective on both dolomite and calcite cores. The system creates high back pressure when foam is generated, which significantly diverts the acid stages to stimulate other intervals. Moreover, the new system minimizes acid leak-off and penetration. Open completing the job, the foam collapse leaving no left behind any damaging material. Field application of the in-situ foam generating system showed high success rate and outperformed other diversion mechanisms. The well gain was up to 18 folds of the original well injectivity.

Structural Performance Assessment of Airfield Concrete Pavements Based on Field and Laboratory Data

Maintenance interventions and rehabilitation actions in airfield pavements are time-consuming and adversely affect pavements’ serviceability (i.e., airport closures), with a profound impact on the airport economics. Once a pavement is constructed, a robust asset management prerequisites systematic and accurate knowledge of pavement condition throughout its service life. Evaluating a pavement’s structural capacity in the field involves the integration of multiple Non-Destructive Testing (NDT) systems, with the Falling Weight Deflectometer (FWD) being the most indicative NDT system for pavement evaluation. The purpose of the present study is to develop a methodology for the assessment of airfield concrete pavements. A new and non-trafficked Jointed Plain Concrete Pavement (JPCP), facing early-life cracks shortly after a runway’s expansion activities, was utilized for the investigation. Multiple types of data collected in the field, including deflections, load transfer efficiency at joints and cracks, concrete thickness through coring as well as data retrieved in the laboratory (concrete’s flexural strength), helped to define the pavement’s performance and assess its damage potential. Overall, the integration of such data can provide the related airport authorities the necessary information in order to make a rational asset management and enhance the efficiency of airfield infrastructures. The methodology is applicable for both new and in-service pavements.

Incidence of Groundnut Leafminer (GLM), Aproaerema modicella (Deventer) (Lepidoptera: Gelechiidae) and its Parasitic Fauna on Alternate Leguminous Hosts in Tamil Nadu, India

Background: The groundnut leafminer (GLM), Aproaerema modicella is an important pest of several legume crops which causes 50 to 100 per cent yield loss in India. The exploration of indigenous natural enemies is crucial to the success of every biological control strategy. Besides, alternative host plants act as a source of both herbivorous pests and their natural enemies. In this view, occurrence of GLM and their parasitic fauna on groundnut, alternate leguminous hosts viz., redgram and babchi were recorded. Methods: Survey on damage potential of GLM and their parasitic fauna were recorded on groundnut at Sivagangai and Coimbatore districts of Tamil Nadu, India during 2016 to 2018. Survey was also conducted to find the damage potential of A. modicella on alternate leguminous hosts viz., redgram, babchi and their parasitic fauna at Coimbatore district. The damage potential of A. modicella, per cent parasitization and parasitoid emergence were assessed from A. modicella infested groundnut, redgram and babchi leaves. Result: Severe incidence of A. modicella was recorded as 98.10% (2016 to 2017) and 98.45% (2017 to 2018) at Sivagangai district. The parasitization of GLM was also found higher at Sivagangai recording 46.67% in both the years which was positively related with the pest population. 13 hymenopteran parasitoids belonging to eight families were recorded. Among them, Avga choaspes Nixon recorded high per cent parasitoid emergence (20.00%). Furthermore, GLM incidence on redgram and babchi indicated the highest damage potential of 38.20 and 34.50 per cent and parasitization of 33.33 and 20.00 per cent, respectively during 2017 to 2018.