Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells

Regulatory Peptides ◽

10.1016/j.regpep.2010.07.115 ◽

2010 ◽

Vol 164 (1) ◽

pp. 44

Author(s):

K. Hunter ◽

Y.H.A. Abdel-Wahab ◽

F.P.M. O'Harte ◽

P.R. Flatt

Keyword(s):

Insulin Secretion ◽

Pancreatic Beta Cells ◽

Inhibitory Action ◽

Islet Amyloid Polypeptide ◽

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Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2009.01.002 ◽

2009 ◽

Vol 41 (7) ◽

pp. 1526-1535 ◽

Author(s):

Xiao-Ling Li ◽

Gang Xu ◽

Tianfeng Chen ◽

Yum-Shing Wong ◽

Hai-Lu Zhao ◽

...

Keyword(s):

Oxidative Stress ◽

Protein Kinase ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Mitogen Activated Protein Kinase ◽

Islet Amyloid ◽

Mitogen Activated Protein ◽

Induced Apoptosis

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Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2010.12.008 ◽

2011 ◽

Vol 43 (4) ◽

pp. 525-534 ◽

Author(s):

Xiao-Ling Li ◽

Tianfeng Chen ◽

Yum-Shing Wong ◽

Gang Xu ◽

Rong-Rong Fan ◽

...

Keyword(s):

Mitochondrial Dysfunction ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Induced Apoptosis

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Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

Diabetologia ◽

10.1007/s001250051138 ◽

1999 ◽

Vol 42 (2) ◽

pp. 188-194 ◽

Author(s):

X. Hou ◽

Z. Ling ◽

E. Quartier ◽

A. Foriers ◽

F. Schuit ◽

...

Keyword(s):

Pancreatic Beta Cells ◽

Prolonged Exposure ◽

Islet Amyloid Polypeptide ◽

Islet Amyloid ◽

Cellular Content

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Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

Diabetologia ◽

10.1007/s00125-008-1111-z ◽

2008 ◽

Vol 51 (12) ◽

pp. 2252-2262 ◽

Author(s):

S. Casas ◽

A. Novials ◽

F. Reimann ◽

R. Gomis ◽

F. M. Gribble

Keyword(s):

Ion Channel ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Mechanosensitive Ion Channel ◽

Calcium Elevation

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Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

Diabetes Obesity and Metabolism ◽

10.1111/j.1463-1326.2010.01238.x ◽

2010 ◽

Vol 12 (9) ◽

pp. 815-824 ◽

Author(s):

R. Fan ◽

X. Li ◽

X. Gu ◽

J. C. N. Chan ◽

G. Xu

Keyword(s):

Pancreatic Beta Cells ◽

Cell Damage ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Damage Potential ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Mitochondria Biogenesis

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Selenium-enriched Spirulina protects INS-1E pancreatic beta cells from human islet amyloid polypeptide-induced apoptosis through suppression of ROS-mediated mitochondrial dysfunction and PI3/AKT pathway

European Journal of Nutrition ◽

10.1007/s00394-014-0732-x ◽

2014 ◽

Vol 54 (4) ◽

pp. 509-522 ◽

Author(s):

Xiao-Ling Li ◽

Yum-Shing Wong ◽

Gang Xu ◽

Juliana C. N. Chan

Keyword(s):

Mitochondrial Dysfunction ◽

Pancreatic Beta Cells ◽

Islet Amyloid Polypeptide ◽

Human Islet ◽

Akt Pathway ◽

Islet Amyloid ◽

Human Islet Amyloid Polypeptide ◽

Induced Apoptosis

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Islet amyloid polypeptide acts on glucose- stimulated beta cells to reduce voltage-gated calcium channel activation, intracellular Ca2+ concentration, and insulin secretion

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.1140 ◽

2010 ◽

Vol 27 (1) ◽

pp. 28-34 ◽

Author(s):

Tiehong Zhu ◽

Yinxia Wang ◽

Bingjun He ◽

Jingjing Zang ◽

Qing He ◽

...

Keyword(s):

Insulin Secretion ◽

Calcium Channel ◽

Islet Amyloid Polypeptide ◽

Islet Amyloid ◽

Channel Activation ◽

Voltage Gated ◽

Voltage Gated Calcium Channel

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Targeted local activation of Fas in pancreatic beta cells for treatment of insulinomas and disorders of pathological autonomic insulin secretion

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2005-862849 ◽

2005 ◽

Vol 113 (S 1) ◽

Author(s):

K Sözener ◽

G Päth ◽

H Wajant ◽

F Henkler ◽

M Lehne ◽

...

Keyword(s):

Insulin Secretion ◽

Pancreatic Beta Cells ◽

Local Activation

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Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

Diabetes ◽

10.2337/diabetes.39.5.634 ◽

1990 ◽

Vol 39 (5) ◽

pp. 634-638 ◽

Author(s):

S. E. Kahn ◽

D. A. D'Alessio ◽

M. W. Schwartz ◽

W. Y. Fujimoto ◽

J. W. Ensinck ◽

...

Keyword(s):

Islet Amyloid Polypeptide ◽

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Involvement of ATP-sensitive K+ channels in free radical-mediated inhibition of insulin secretion in rat pancreatic beta-cells

Diabetes ◽

10.2337/diabetes.44.8.878 ◽

1995 ◽

Vol 44 (8) ◽

pp. 878-883 ◽

Author(s):

M. Nakazaki ◽

M. Kakei ◽

N. Koriyama ◽

H. Tanaka

Keyword(s):

Insulin Secretion ◽

Free Radical ◽

Pancreatic Beta Cells ◽

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