scholarly journals The World Health Organization International Collaborative Study for Islet Cell Antibodies

Diabetologia ◽  
2000 ◽  
Vol 43 (10) ◽  
pp. 1282-1292 ◽  
Author(s):  
A. R. Mire-Sluis ◽  
R. Gaines Das ◽  
Å. Lernmark
Keyword(s):  
World Health Organization ◽  
Islet Cell ◽  
Collaborative Study ◽  
Islet Cell Antibodies ◽  
World Health ◽  
The World ◽  
International Collaborative ◽  
Health Organization ◽  
International Collaborative Study

Oral Health Care Systems: An International Collaborative Study Coordinated by the World Health Organization

1987 ◽  
Vol 8 (1) ◽  
pp. 125
Author(s):  
Max H. Schoen ◽  
Harald A. Arnljot ◽  
David E. Barmes ◽  
Lois K. Cohen ◽  
Peter B. V. Hunter ◽  
...  
Keyword(s):  
Health Care ◽  
Oral Health ◽  
World Health Organization ◽  
Health Care Systems ◽  
Collaborative Study ◽  
World Health ◽  
The World ◽  
Care Systems ◽  
Health Organization ◽  
International Collaborative Study

International Collaborative Study for the Calibration of a Proposed Reference Preparation for Thromboplastin, Human Recombinant, Plain

1998 ◽  
Vol 79 (02) ◽  
pp. 439-443 ◽  
Author(s):  
Veena Chantarangkul ◽  
Barbara Negri ◽  
Marigrazia Clerici ◽  
Pier Mannuccio Mannucci ◽  
Armando Tripodi
Keyword(s):  
Collaborative Study ◽  
Mean Value ◽  
World Health ◽  
Practical Reasons ◽  
Calibration Model ◽  
Average Value ◽  
Reference Preparation ◽  
International Collaborative ◽  
Health Organization ◽  
International Collaborative Study

SummaryStocks of the International Reference Preparation (IRP) for thromboplastin, human, plain, coded BCT/253 and held by the World Health Organization (WHO) are nearly exhausted and must be replaced. For practical reasons the choice of the replacement candidate was restricted to two available human recombinant preparations which were coded as X/95 and Y/95 and calibrated in an international collaborative study involving 19 laboratories from Europe, Australia, Canada and Argentina. To minimize the differences between routes of calibration, the two candidates were calibrated against the existing WHO-IRP from human, rabbit and bovine origin and the final ISI was the resultant average value. On the basis of predefined criteria (i.e., within- and between-laboratory precision of the calibration and the conformity to the calibration model), X/95 was the preferred candidate. The assigned ISI (SE of the mean) value is 0.940 (0.0060) and the interlaboratory coefficient of variation 4.7%.

The Second International Reference Preparation of Thyroid-Stimulating Hormone, Human, for Immunoassay: calibration by bioassay and immunoassay in an international collaborative study

1985 ◽  
Vol 104 (3) ◽  
pp. 367-379 ◽  
Author(s):  
R. E. Gaines Das ◽  
A. F. Bristow
Keyword(s):  
Collaborative Study ◽  
Thyroid Stimulating Hormone ◽  
World Health ◽  
Expert Committee ◽  
International Reference ◽  
Reference Preparation ◽  
International Collaborative ◽  
Health Organization ◽  
International Collaborative Study ◽  
Second International

ABSTRACT Four batches of ampouled materials in ampoules coded 80/558, 81/502, 81/565 and 81/615 were evaluated by 22 laboratories in nine countries in an international collaborative study for their suitability to serve as a replacement for the First International Reference Preparation (IRP) of TSH, Human, for Immunoassay. The ampouled preparations were calibrated by immunoassay and bioassay. The preparation coded 80/558 had satisfactory stability and contained acceptably low levels of contamination with FSH and LH. Estimates of the immunoreactive TSH content of a set of specimens of serum in terms of 80/558 showed agreement in ranking order and no increase in variability compared with estimates made by assay against the First IRP. On the basis of these results, with the agreement of the participants in the study, and with the authorization of the Expert Committee on Biological Standardization of the World Health Organization, the preparation coded 80/558 was established in 1983 as the Second International Reference Preparation of TSH, Human, for Immunoassay, with a defined potency of 37 mi.u./ampoule. Preparations coded 81/502, 81/565 and 81/615 were found suitable to serve as working standards. J. Endocr. (1985) 104, 367–379

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