scholarly journals Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons

Diabetologia ◽  
2001 ◽  
Vol 44 (10) ◽  
pp. 1302-1309 ◽  
Author(s):  
E. Kostyuk ◽  
N. Voitenko ◽  
I. Kruglikov ◽  
A. Shmigol ◽  
V. Shishkin ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Homeostasis ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Nociceptive Neurons ◽  
Induced Changes

Effects of calcium channel blockers on stimulation-induced changes in transmitter release at the frog neuromuscular junction

Synapse ◽  
1993 ◽  
Vol 15 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Janet E. Zengel ◽  
David T. Lee ◽  
Maria A. Sosa ◽  
Dennis R. Mosier
Keyword(s):  
Neuromuscular Junction ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Transmitter Release ◽  
Frog Neuromuscular Junction ◽  
Channel Blockers ◽  
Induced Changes

Cardiovascular and renal actions of endothelin: effects of calcium-channel blockers

1990 ◽  
Vol 258 (2) ◽  
pp. F254-F258 ◽  
Author(s):  
L. Q. Cao ◽  
R. O. Banks
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Filtration Rate ◽  
Female Rats ◽  
Channel Blockers ◽  
Male And Female ◽  
Pentobarbital Sodium ◽  
Renal Action ◽  
Entire Experiment ◽  
Induced Changes

We have evaluated the effects of two calcium-channel blockers, verapamil (VP) and manganese (Mn), on endothelin (EN)-induced changes in systemic and renal function in pentobarbital sodium-anesthetized female rats and male and female dogs. In the rat studies, saline was infused at 24 microliters/min iv with or without (n = 10) two doses of VP (0.02 mg.kg-1.min-1, n = 5; 0.03 mg.kg-1.min-1, n = 3) or Mn (0.5 mg.kg-1.min-1, n = 5) throughout the entire experiment. After surgery, rats were allowed 60 min to stabilize, and three 20-min control clearances were collected. EN (100 ng.kg-1.min-1) was then added to the infusate for 30 min. EN alone caused an increase in mean arterial pressure (MAP) and a decrease in the glomerular filtration rate (GFR). VP at either dose and Mn totally blocked the EN-induced increase in MAP. However, the two calcium-channel blockers had no effect on the renal action of EN; the GFR (in ml/min) decreased (at 30 min of EN infusion) from 2.7 +/- 0.1 (SE) to 0.7 +/- 0.1 (P less than 0.01) in controls, from 2.5 +/- 0.3 to 0.4 +/- 0.3 with the lower dose of VP (P less than 0.01), from 2.3 +/- 0.1 to 0.6 +/- 0.2 with the higher dose of VP (P less than 0.01), and from 1.5 +/- 0.5 to 0.9 +/- 0.6 with Mn (P less than 0.05). Infusion of EN alone (10 ng.kg-1.min-1, n = 5) and EN with VP (50 micrograms/min, n = 3) into the renal artery of dogs reduced renal blood flow from 3.5 +/- 0.4 to 0.9 +/- 0.2 and from 3.6 +/- 0.6 to 1.2 +/- 0.6 ml.g-1.min-1, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium channel blockers Nifedipine and Verapamil protect mouse hepatocytes from both TGF-β and ethanol dependent damage

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
S Ehnert ◽  
A Müller ◽  
A Bachmann ◽  
MV Singer ◽  
S Dooley ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Mouse Hepatocytes

Electroanalytical Methods for Determination of Calcium Channel Blockers

2019 ◽  
Vol 15 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Fatma Ağın
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Heart Diseases ◽  
Dosage Forms ◽  
Channel Blockers ◽  
Electroanalytical Methods ◽  
Pharmaceutical Dosage Forms ◽  
Ischemic Heart Diseases

Background:Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanalytical methods are very powerful analytical methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations (10-50 ng/ml). The purpose of this review is to gather electroanalytical methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biological media selected mainly from current articles.Methods:This review mainly includes recent determination studies of calcium channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples. The studies of calcium channel blockers electroanalytical determination in the literature were reviewed and interpreted.Results:There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs.Conclusion:Electroanalytical methods especially voltammetric methods supply reproducible and reliable results for the analysis of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatographic methods.

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