No Estrogenic Effects of Bisphenol A in Daphnia magna STRAUS

1998 ◽  
Vol 61 (2) ◽  
pp. 143-148 ◽  
Author(s):  
N. Caspers
Keyword(s):  
Bisphenol A ◽  
Daphnia Magna ◽  
Estrogenic Effects

scholarly journals Coexposure to Phytoestrogens and Bisphenol A Mimics Estrogenic Effects in an Additive Manner

2013 ◽  
Vol 138 (1) ◽  
pp. 21-35 ◽  
Author(s):  
Anne Katchy ◽  
Caroline Pinto ◽  
Philip Jonsson ◽  
Trang Nguyen-Vu ◽  
Marchela Pandelova ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Estrogenic Effects

scholarly journals Acute and chronic toxicity of mixtures of bisphenol A and trace metals (Cd and Pb) to micro-crustacean, Daphnia magna

2022 ◽  
Vol 964 (1) ◽  
pp. 012012
Author(s):  
V T Nguyen ◽  
A T Huynh ◽  
T S Dao
Keyword(s):  
Trace Metals ◽  
Bisphenol A ◽  
Daphnia Magna ◽  
Aquatic Ecosystems ◽  
Life History Traits ◽  
Feeding Rate ◽  
Aquatic Organisms ◽  
Antagonistic Effect ◽  
Ecological Impacts ◽  
Plastic Materials

Abstract The occurrence of plastic additives and their ecological impacts have attracted much attention in recent years globally. Among plastic additives, the trace metals (e.g., Cd, Pb) are widely used as color pigments and stabilizers, whereas bisphenol A (BPA) is added to enhance the desired physical characteristics of plastic products. However, these additives can easily leach out of plastic materials and enter the aquatic environment causing risks to aquatic ecosystems. Although the toxicity of a single additive on various aquatic organisms has been studied, the responses of zooplankton exposed to the mixed plastic additives have not been fully understood. Therefore, this study aims to evaluate the effects of the binary mixtures (BPA+Cd, BPA+Pb) and trinary mixture (BPA+Pb+Cd) at the metal concentrations of 5 µg/L and BPA level of 50 µg/ L on the life history traits and food feeding rate of the freshwater micro-crustacean, Daphnia magna. The results showed exposures to these mixtures for 24h could significantly enhance the food feeding rate of D. magna from 2.5 – 5.8 times higher than the control. The survival rate was decreased from 50 – 90% in the organisms exposed to these mixtures after 18 incubated days. We found a synergistic effect of BPA+Pb but an antagonistic effect of BPA+Pb+Cd on the survivorship of D. magna. Similarly, the organisms in the exposures delayed their maturity age and reduced their reproduction. The potent impact order of the mixtures on D. magna was BPA+Cd > BPA+Pb+Cd > BPA+Pb. Our results evidenced the adverse effects of plastic additive mixtures on aquatic organisms. Therefore, the use and disposal of plastic materials and plastic additives should be paid more attention to protect the environment, ecosystem, and human health. Moreover, our findings proved that the toxicity of multi-contaminants on organisms could be unpredictable even the toxicity of a single contaminant is known.

scholarly journals Insight Into The Aquatic Toxicity And Ecological Risk of Bisphenol B, And Comparison With That of Bisphenol A

2021 ◽  
Author(s):  
Yue Wang ◽  
Tianyi Zhao ◽  
Xianhai Yang ◽  
Huihui Liu
Keyword(s):  
Bisphenol A ◽  
Daphnia Magna ◽  
Ecological Risk ◽  
Aquatic Toxicity ◽  
Aquatic Organisms ◽  
The Body ◽  
Risk Quotient ◽  
Effect Concentration ◽  
Detectable Rate ◽  
Insight Into

Abstract As one of the alternatives of 2,2-bis(4-hydroxyphenyl)propane (bisphenol A, BPA), 2,2-bis(4-hydroxyphenyl)butane (bisphenol B, BPB) has not gained sufficient concerns so far, due to the limited concentration and toxicity data available. In this study, the acute toxicity of BPB to three aquatic organisms, i.e., Tetradesmus obliquus, Daphnia magna and Danio rerio, was investigated, and it showed that Daphnia magna was the most sensitive organism with the half effective concentration (EC50) of 3.93 mg/L. Thereout, the screened Daphnia magna was exposed to BPB for 21 days to explore the chronic toxicity. Results indicated that BPB restricted the body length of parent Daphnia magna and reduced the total number of broods and neonates. The no-observed effect concentration of BPB to Daphnia magna was as low as 0.01 mg/L, which was two orders of magnitude lower than that reported 0.86–5.00 mg/L of BPA. Furthermore, the ecological risk of BPB was quantitatively assessed using the risk quotient (RQ) method. Obviously, although the environmental concentrations and detectable rate of BPB were much lower than that of BPA, its ecological risk was not necessarily lower. Hence, BPB should not be ignored in the future environmental monitoring and management.

Abstract 617: Bisphenol A Inhibits GPR30-Mediated Dilation of Mesenteric Resistance Arteries

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Sarah Lindsey ◽  
Melyssa Bratton ◽  
John A McLachlan
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Cardiovascular Effects ◽  
Mesenteric Arteries ◽  
The Novel ◽  
Resistance Arteries ◽  
Endocrine Disrupting Chemical ◽  
Downstream Signaling ◽  
Estrogenic Effects ◽  
Endocrine Disrupting

We previously showed that activation of the membrane estrogen receptor GPR30 decreases blood pressure in hypertensive ovariectomized mRen2.Lewis rats and acutely dilates mesenteric resistance arteries. These studies suggest that GPR30 plays a role in estrogen’s beneficial cardiovascular effects. Bisphenol A (BPA) is an endocrine-disrupting chemical found in most manufactured plastic products that also binds to GPR30 in the nanomolar range. Clinical studies show a significant correlation between elevated urinary BPA and increased diagnosis of cardiovascular diseases including hypertension. Therefore, we hypothesized that BPA may disrupt the vasodilatory effects mediated by the novel estrogen receptor GPR30. Second-order mesenteric arteries from 15 week-old Lewis females were denuded and mounted on a wire myograph. Arteries were preconstricted with 10 μM phenylephrine before assessing the response to increasing concentrations of the selective GPR30 agonist G-1 (0.001-3 μM). Pretreatment with 10 μM BPA significantly inhibited G-1-induced relaxation of denuded vessels (Figure, *P<0.01). In summary, BPA blocked the vasodilatory actions of G-1 in vascular smooth muscle, perhaps by competing for GPR30 and/or altering its downstream signaling. We conclude that human exposure to BPA may interfere with the protective estrogenic effects mediated by GPR30.

scholarly journals Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae

2017 ◽  
Vol 51 (21) ◽  
pp. 12796-12805 ◽  
Author(s):  
John Moreman ◽  
Okhyun Lee ◽  
Maciej Trznadel ◽  
Arthur David ◽  
Tetsuhiro Kudoh ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Bisphenol A ◽  
Zebrafish Embryo ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Estrogenic Effects ◽  
Bisphenol Af
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