scholarly journals Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae

2017 ◽  
Vol 51 (21) ◽  
pp. 12796-12805 ◽  
Author(s):  
John Moreman ◽  
Okhyun Lee ◽  
Maciej Trznadel ◽  
Arthur David ◽  
Tetsuhiro Kudoh ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Bisphenol A ◽  
Zebrafish Embryo ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Estrogenic Effects ◽  
Bisphenol Af

scholarly journals Bisphenol AF and Bisphenol F Induce Similar Feminizing Effects in Chicken Embryo Testis as Bisphenol A

2020 ◽  
Vol 178 (2) ◽  
pp. 239-250
Author(s):  
Anna Mentor ◽  
Mimmi Wänn ◽  
Björn Brunström ◽  
Maria Jönsson ◽  
Anna Mattsson
Keyword(s):  
Bisphenol A ◽  
Chicken Embryo ◽  
Reproductive Organ ◽  
Testis Size ◽  
Organ Development ◽  
Bisphenol S ◽  
Left Testis ◽  
Bisphenol F ◽  
Bisphenol Af ◽  
Somatic Index

Abstract The plastic component bisphenol A (BPA) impairs reproductive organ development in various experimental animal species. In birds, effects are similar to those caused by other xenoestrogens. Because of its endocrine disrupting activity, BPA is being substituted with other bisphenols in many applications. Using the chicken embryo model, we explored whether the BPA alternatives bisphenol AF (BPAF), bisphenol F (BPF), and bisphenol S (BPS) can induce effects on reproductive organ development similar to those induced by BPA. Embryos were exposed in ovo from embryonic day 4 (E4) to vehicle, BPAF at 2.1, 21, 210, and 520 nmol/g egg, or to BPA, BPF, or BPS at 210 nmol/g egg and were dissected on embryonic day 19. Similar to BPA, BPAF and BPF induced testis feminization, manifested as eg testis-size asymmetry and ovarian-like cortex in the left testis. In the BPS-group, too few males were alive on day 19 to evaluate any effects on testis development. We found no effects by any treatment on ovaries or Müllerian ducts. BPAF and BPS increased the gallbladder-somatic index and BPAF, BPF and BPS caused increased embryo mortality. The overall lowest-observed-adverse-effect level for BPAF was 210 nmol/g egg based on increased mortality, increased gallbladder-somatic index, and various signs of testis feminization. This study demonstrates that the BPA replacements BPAF, BPF, and BPS are embryotoxic and suggests that BPAF is at least as potent as BPA in inducing estrogen-like effects in chicken embryos. Our results support the notion that these bisphenols are not safe alternatives to BPA.

Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells

Chemosphere ◽  
2020 ◽  
Vol 253 ◽  
pp. 126707 ◽  
Author(s):  
Mingquan Huang ◽  
Shuang Liu ◽  
Li Fu ◽  
Xue Jiang ◽  
Meng Yang
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Bisphenol Af

Gd3+ doped BiVO4 and visible light-emitting diodes (LED) for photocatalytic decomposition of bisphenol A, bisphenol S and bisphenol AF in water

2021 ◽  
pp. 105842
Author(s):  
Carolina Orona-Návar ◽  
Yuri Park ◽  
Varsha Srivastava ◽  
Netzahualpille Hernández ◽  
Jürgen Mahlknecht ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Visible Light ◽  
Light Emitting Diodes ◽  
Photocatalytic Decomposition ◽  
Bisphenol S ◽  
Light Emitting ◽  
Bisphenol Af

scholarly journals Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites

2017 ◽  
Vol 44 ◽  
pp. 287-302 ◽  
Author(s):  
Lalith Perera ◽  
Yin Li ◽  
Laurel A. Coons ◽  
Rene Houtman ◽  
Rinie van Beuningen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bisphenol A ◽  
Potential Interaction ◽  
Bisphenol S ◽  
Interaction Sites ◽  
Bisphenol Af ◽  
Stimulation Of

Bisphenol A, Bisphenol AF, and Bisphenol S - A comparison of pre- and postnatal endpoints

2018 ◽  
Vol 80 ◽  
pp. 32
Author(s):  
Vicki L. Sutherland ◽  
Barry McIntyre ◽  
Helen Cunny ◽  
Suramya Waidyanatha ◽  
Jui-Hua Hsieh ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Bisphenol Af

scholarly journals Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

2021 ◽  
Author(s):  
Tomas Prudencio ◽  
Luther Swift ◽  
Devon Guerrelli ◽  
Blake Cooper ◽  
Marissa Reilly ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Safety Profile ◽  
Intracellular Signaling ◽  
Cardiac Electrophysiology ◽  
Field Potential ◽  
Production Volume ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Bisphenol Analogues ◽  
Whole Heart

ABSTRACTBackgroundBisphenol A (BPA) is a high-production volume chemical that is commonly used to manufacture consumer and medical-grade plastic products. Due to its ubiquity, the general population can incur daily environmental exposure to BPA, while heightened BPA exposure has been reported in intensive care patients and industrial workers. Due to health concerns, structural analogues are being explored as replacements for BPA.ObjectiveThis study aimed to examine the direct nongenomic effects of BPA on cardiac electrophysiology and compare its safety profile to recently developed alternatives, including BPS (bisphenol S) and BPF (bisphenol F).MethodsWhole-cell voltage-clamp recordings were performed on cell lines transfected with Nav1.5, hERG, or Cav1.2. Results of single channel experiments were validated by conducting electrophysiology studies on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and intact, whole heart preparations.ResultsOf the chemicals tested, BPA was the most potent inhibitor of both fast (INa-P) and late (INa-L) sodium channel (IC50 = 55.3 and 23.6 μM, respectively), L-type calcium channel (IC50 = 30.8 μM) and hERG channel current (IC50 = 127 μM). The inhibitory effects of BPA and BPF on L-type calcium channels were supported by microelectrode array recordings, which revealed shortening of the extracellular field potential (akin to QT interval). Further, BPA and BPF exposure impaired atrioventricular conduction in intact, whole heart experiments. BPS did not alter any of the cardiac electrophysiology parameters tested.DiscussionResults of this study demonstrate that BPA and BPF exert an immediate inhibitory effect on cardiac ion channels, and that BPS may be a safer alternative. Intracellular signaling or genomic effects of bisphenol analogues were not investigated; therefore, additional mechanistic studies are necessary to fully elucidate the safety profile of bisphenol analogues on the heart.

Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats

Chemosphere ◽  
2018 ◽  
Vol 209 ◽  
pp. 508-516 ◽  
Author(s):  
Asad Ullah ◽  
Madeeha Pirzada ◽  
Sarwat Jahan ◽  
Hizb Ullah ◽  
Ghazala Shaheen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
In Vivo Studies ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

2020 ◽  
Vol 21 (10) ◽  
pp. 3529 ◽  
Author(s):  
Magdalena Zaborowska ◽  
Jadwiga Wyszkowska ◽  
Agata Borowik
Keyword(s):  
Genetic Diversity ◽  
Alkaline Phosphatase ◽  
Bisphenol A ◽  
Negative Impact ◽  
Soil Microbiome ◽  
Colony Development ◽  
Biochemical Activity ◽  
Bisphenol S ◽  
Study Objective ◽  
Bisphenol F

The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) and bisphenol S (BPS)—analogues of bisphenol A (BPA). The study focused on the determination and comparison of the scale of the BPA, BPF, and BPS impact on the soil microbiome and its enzymatic activity. The following parameters were determined in soil uncontaminated and contaminated with BPA, BPF, and BPS: the count of eleven groups of microorganisms, colony development (CD) index, microorganism ecophysiological diversity (EP) index, genetic diversity of bacteria and activity of dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline phosphatase (Pal), arylsulphatase (Aryl) and β-glucosidase (Glu). Bisphenols A, S and F significantly disrupted the soil homeostasis. BPF is regarded as the most toxic, followed by BPS and BPA. BPF and BPS reduced the abundance of Proteobacteria and Acidobacteria and increased that of Actinobacteria. Unique types of bacteria were identified as well as the characteristics of each bisphenol: Lysobacter, Steroidobacter, Variovorax, Mycoplana, for BPA, Caldilinea, Arthrobacter, Cellulosimicrobium and Promicromonospora for BPF and Dactylosporangium Geodermatophilus, Sphingopyxis for BPS. Considering the strength of a negative impact of bisphenols on the soil biochemical activity, they can be arranged as follows: BPS > BPF > BPA. Urease and arylsulphatase proved to be the most susceptible and dehydrogenases the least susceptible to bisphenols pressure, regardless of the study duration.

Sign in / Sign up

Export Citation Format

Share Document