Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

2020 ◽  
Vol 46 (4) ◽  
pp. 717-726 ◽  
Author(s):  
Anders Granholm ◽  
Søren Marker ◽  
Mette Krag ◽  
Fernando G. Zampieri ◽  
Hans-Christian Thorsen-Meyer ◽  
...  
Keyword(s):  
Treatment Effect ◽  
Icu Patients ◽  
Post Hoc Analysis ◽  
Heterogeneity Of Treatment Effect ◽  
Post Hoc

scholarly journals Duration of treatment effect using incobotulinumtoxinA for upper-limb spasticity: A post hoc analysis

Toxicon ◽  
2021 ◽  
Vol 190 ◽  
pp. S37
Author(s):  
Petr Kaňovský ◽  
Elie P. Elovic ◽  
Angelika Hanschmann ◽  
Irena Pulte ◽  
Michael Althaus ◽  
...  
Keyword(s):  
Upper Limb ◽  
Treatment Effect ◽  
Duration Of Treatment ◽  
Post Hoc Analysis ◽  
Limb Spasticity ◽  
Post Hoc

scholarly journals Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0247939
Author(s):  
Wiebe M. C. Top ◽  
Philippe Lehert ◽  
Casper G. Schalkwijk ◽  
Coen D. A. Stehouwer ◽  
Adriaan Kooy
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Natriuretic Peptide ◽  
Treatment Effect ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Initial Increase ◽  
Post Hoc Analysis ◽  
Post Hoc

Background Beyond antihyperglycemic effects, metformin may improve cardiovascular outcomes. Patients with type 2 diabetes often have an elevated plasma level of N-terminal pro B-type as a marker of (sub) clinical cardiovascular disease. We studied whether metformin was associated with a reduction in the serum level of N-terminal pro B-type natriuretic peptide (NT-proBNP) in these patients. Methods In the HOME trial 390 insulin-treated patients with type 2 diabetes were randomized to 850 mg metformin or placebo three times daily. Plasma samples were drawn at baseline, 4, 17, 30, 43 and 52 months. In a post-hoc analysis we analyzed the change in NT-proBNP in both groups. We used a longitudinal mixed model analysis adjusting for age, sex and prior cardiovascular disease. In a secondary analysis we assessed a possible immediate treatment effect post baseline. Results Metformin did not affect NT-proBNP levels over time in the primary analysis (-1% [95%CI -4;3, p = 0.62]). In the secondary analysis there was also no sustained time independent immediate treatment effect (initial increase of 17% [95%CI 4;30, p = 0.006] followed by yearly decrease of -4% [95%CI -7;0, p = 0.07]). Conclusions Metformin as compared to placebo did not affect NT-proBNP plasma levels in this 4.3-year placebo-controlled trial. Potential cardioprotective effects of metformin cannot be explained by changes in cardiac pressures or volumes to the extent reflected by NT-proBNP.

Short-term dialysis catheter versus central venous catheter infections in ICU patients: a post hoc analysis of individual data of 4 multi-centric randomized trials

2019 ◽  
Vol 45 (12) ◽  
pp. 1774-1782 ◽  
Author(s):  
Niccolò Buetti ◽  
Stéphane Ruckly ◽  
Jean-Christophe Lucet ◽  
Olivier Mimoz ◽  
Bertrand Souweine ◽  
...  
Keyword(s):  
Randomized Trials ◽  
Venous Catheter ◽  
Dialysis Catheter ◽  
Individual Data ◽  
Central Venous ◽  
Short Term ◽  
Icu Patients ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
Catheter Infections

scholarly journals Is there an association between subjective sleep quality and daily delirium occurrence in critically ill adults? A post hoc analysis of a randomised controlled trial

2020 ◽  
Vol 7 (1) ◽  
pp. e000576 ◽  
Author(s):  
Matthew S Duprey ◽  
John W Devlin ◽  
Yoanna Skrobik
Keyword(s):  
Regression Analysis ◽  
Intensive Care ◽  
Randomised Controlled Trial ◽  
Sleep Quality ◽  
Controlled Trial ◽  
Predictive Analysis ◽  
Icu Patients ◽  
Post Hoc Analysis ◽  
Randomised Controlled ◽  
Post Hoc

ObjectivesWhether and how delirium and sleep quality in the intensive care unit (ICU) are linked remains unclear. A recent randomised trial reported nocturnal low-dose dexmedetomidine (DEX) significantly reduces incident ICU delirium. Leeds Sleep Evaluation Questionnaire (LSEQ) scores were similar between intervention (DEX; n=50) and control (placebo (PLA); n=50) groups. We measured the association between morning LSEQ and delirium occurrence in the prior 24 hours (retrospective analysis) and the association between morning LSEQ and delirium occurrence in the following 24 hours (predictive analysis).DesignPost hoc analysis of randomised controlled trial data.ParticipantsAdult ICU patients (n=100) underwent delirium screening twice a day using the Intensive Care Delirium Screening Checklist (ICDSC) if Richmond Agitation Sedation Scale (RASS) was ≥−3 and patient-reported sleep quality evaluations at 09:00 daily with the LSEQ if RASS was ≥−1.OutcomesThe analysis included all 24-hour study periods with LSEQ documentation and matched delirium screening in coma-free patients. Separate logistic regression models controlling for age, baseline Acute Physiology and Chronic Health Evaluation II score and DEX/PLA allocation evaluated the association between morning LSEQ and delirium occurrence for both retrospective and predictive analyses.ResultsThe 100 patients spent 1115 24-hour periods in the ICU. Coma, delirium and no delirium occurred in 130 (11.7%), 114 (10.2%) and 871 (78.1%), respectively. In the retrospective analysis, when an LSEQ result was preceded by an ICDSC result (439/985 (44.6%) 24-hour periods), delirium occurred during 41/439 (9.3%) periods. On regression analysis, the LSEQ score had no relationship to prior delirium occurrence (OR (per every 1 point average LSEQ change) 0.97, 95% CI 0.72 to 1.31). For the predictive analysis, among the 387/985 (39.1%) 24-hour periods where an LSEQ result was followed by an ICDSC result, delirium occurred during 56/387 (14.5%) periods. On regression analysis, the LSEQ score did not predict subsequent delirium occurrence (OR (per 1 point LSEQ change) 1.02, 95% CI 0.99 to 1.05).ConclusionsThe sleep quality ICU patients perceive neither affects nor predicts delirium occurrence.Trial registration numberNCT01791296

scholarly journals Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial

2019 ◽  
Vol 45 (5) ◽  
pp. 609-618 ◽  
Author(s):  
Søren Marker ◽  
◽  
Anders Perner ◽  
Jørn Wetterslev ◽  
Mette Krag ◽  
...  
Keyword(s):  
Icu Patients ◽  
Post Hoc Analysis ◽  
Severity Of Disease ◽  
High Severity ◽  
Post Hoc

Heterogeneity of treatment effect of stress ulcer prophylaxis in ICU patients: A secondary analysis protocol

2019 ◽  
Vol 63 (9) ◽  
pp. 1251-1256 ◽  
Author(s):  
Anders Granholm ◽  
Søren Marker ◽  
Mette Krag ◽  
Fernando G. Zampieri ◽  
Hans‐Christian Thorsen‐Meyer ◽  
...  
Keyword(s):  
Treatment Effect ◽  
Stress Ulcer ◽  
Secondary Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Icu Patients ◽  
Heterogeneity Of Treatment Effect ◽  
Ulcer Prophylaxis ◽  
Analysis Protocol

Effectiveness of Social and Correctness Reinforcers with Different Aged Children

1973 ◽  
Vol 33 (3) ◽  
pp. 787-792 ◽  
Author(s):  
Douglas D. Settles ◽  
Norman H. Hamm
Keyword(s):  
Middle Class ◽  
Treatment Effect ◽  
Sorting Task ◽  
Eighth Grade ◽  
Social Approval ◽  
Post Hoc Analysis ◽  
Post Hoc

The effectiveness of two classes of verbal reinforcers, correctness and social, were examined among 108 second-, fifth-, and eighth-grade, middle-class children using a marble-sorting task. Results indicated that correctness reinforcement was more rewarding across all levels of age than social approval; however, a post hoc analysis of the age by treatment effect indicated a significant reinforcer effect for only the eighth-grade Ss.

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