Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial

2021 ◽  
Author(s):  
Gerald Matchett ◽  
Irina Gasanova ◽  
Christina A. Riccio ◽  
Dawood Nasir ◽  
Mary C. Sunna ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Endotracheal Intubation

Steroid Treatment of Laryngotracheitis: A Meta-Analysis of the Evidence From Randomized Trials

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 683-693 ◽  
Author(s):  
Steven W. Kairys ◽  
Elaine Marsh Olmstead ◽  
Gerald T. O'Connor
Keyword(s):  
Clinical Trial ◽  
Confidence Interval ◽  
Randomized Clinical Trial ◽  
Clinical Improvement ◽  
Endotracheal Intubation ◽  
Odds Ratio ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Steroid Treatment ◽  
Reliable Estimate

The use of adrenocorticoids to reduce the morbidity associated with laryngotracheitis (croup) remains controversial despite ten published reports of randomized trials involving 1,286 patients. To determine whether, viewed in aggregate, these studies demonstrate a significant benefit of steroid treatment for this disorder, a meta-analysis of the nine methodologically satisfactory trials was performed. Clinical improvement 12 and 24 hours posttreatment and incidence of endotracheal intubation were evaluated. For each end point, an estimate of the overall effect was obtained by calculating a typical odds ratio and 95% confidence interval. This analysis indicates that the use of steroids in children hospitalized with croup is associated with a significantly increased proportion of patients showing clinical improvement 12 hours (odds ratio = 2.25, 95% confidence interval = 1.66, 3.06) and 24 hours (odds ratio = 3.19, 95% confidence interval = 1.70, 5.99) posttreatment and a significantly reduced incidence of endotracheal intubation (odds ratio = 0.21, 95% confidence interval = 0.05, 0.84). Higher initial doses of steroid (≥125 mg of cortisone or ≥100 mg of hydrocortisone) were associated with a larger proportion of patients improved 12 hours posttreatment than was seen with lower doses. These results support the use of steroids in the treatment of hospitalized children with croup and, in the absence of a randomized clinical trial of sufficient size, provide the most reliable estimate of the impact of steroid therapy on the morbidity associated with croup. In addition, the results of this meta-analysis may be used to estimate the number of subjects who would be required to conduct a randomized clinical trial of steroids for the treatment of croup.

Nasal High-Flow Preoxygenation for Endotracheal Intubation in the Critically Ill Patient: A Randomized Clinical Trial

2018 ◽  
Author(s):  
Christophe Guitton ◽  
Stephan Ehrmann ◽  
Christelle Volteau ◽  
Gwenhael Colin ◽  
Adel Maamar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Critically Ill ◽  
Endotracheal Intubation ◽  
High Flow ◽  
Critically Ill Patient

scholarly journals Comparison of 2 µg/kg of fentanyl and 150 µg/kg oxycodone during induction on post-intubation hemodynamics: a randomized clinical trial

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Suwarman Suwarman ◽  
Budiana Rismawan ◽  
Rizky Heiry
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Heart Rate ◽  
Randomized Clinical Trial ◽  
Respiratory Depression ◽  
Endotracheal Intubation ◽  
Group Versus ◽  
Time Points ◽  
Post Intubation ◽  
Fentanyl Group

 Context: Endotracheal intubation may cause increased blood pressure and heart rate. The use of fentanyl as pre-intubation medication may blunt the hemodynamic changes. However, fentanyl has side effects of sedation and respiratory depression. Oxycodone is an opioid similar to fentanyl that may be used as preintubation medication with less effects on sedation and respiratory depression. Aims: This study aimed to compare the effect of 150 µg/kg oxycodone and 2 µg/kg fentanyl during induction on post-intubation blood pressure and heart rate changes. Methodology: The study was a double-blind, randomized clinical trial in 40 patients ASA I-II aged between 19-65 years old undergoing elective surgery under general anesthesia. The patients were divided into 2 groups, one receiving 150 µg/kg oxycodone and one receiving 2 µg/kg fentanyl during induction. Blood pressure and heart rate were recorded before induction (T0), before intubation (T1), just after intubation (T2), 3 min after intubation (T3) and 5 min after intubation (T4). Statistical data was analyzed using unpaired t-test and Mann-Whitney test, where p < 0.05 was considered significant. Results: The results showed significant differences (p < 0.05) in MAP ( and #61508;MAP) in every time points assessed (12.15  ±  6.753, 13.40  ±  6.143, and 17.59  ±  7.715 in oxycodone group versus 3.65  ±  3.746, 6.05  ±  4.186, and 9.40  ±  6.484 in fentanyl group, consecutively). This study also showed significant differences (p < 0.05) in heart rate in every time points assessed (3,40  ±  4.212, 8.35  ±  4,891 and 10.45  ±  6.253 in oxycodone group versus -4.80  ±  6.477, -2.15  ±  4.671, and -1.20  ±  6.978 in fentanyl group, consecutively). Conclusions: Administration of 150 µg/kg oxycodone during induction causes smaller increase in post-endotracheal intubation blood pressure and heart rate compared to 2 µg/kg fentanyl. Key words: Blood pressure; Fentanyl; Heart rate; Intubation; Oxycodone; Post-intubation hemodynamic Citation: Suwarman, Rismawan B, Rizky Heiry R. Comparison of 2 µg/kg of fentanyl and 150 µg/kg oxycodone during induction on post-intubation hemodynamics: a randomized clinical trial. Anaesth. pain intensive care 2021;25(1):71–75; DOI: 10.35975/apic.v25i1.1443 Received: 25 September 2020, Reviewed: 4 January 2021, Accepted: 10 January 2021

scholarly journals Effects of intravenous and inhaled nebulized lignocaine on the hemodynamic response of endotracheal intubation patients: A randomized clinical trial

2018 ◽  
Vol 12 (1) ◽  
pp. 159 ◽  
Author(s):  
Arash Yazdanbakhsh ◽  
Abolfazl Jokar ◽  
Maryam Babaei ◽  
Sahar Pourmatin ◽  
Majid Taheri ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Endotracheal Intubation ◽  
Hemodynamic Response

scholarly journals PERBANDINGAN EFEKTIFITAS DEXAMETHASON DAN LIDOKAIN DALAM MENCEGAH NYERI TENGGOROKAN SETELAH INTUBASI ENDOTRAKEAL PADA ANESTESI UMUM

2019 ◽  
Vol 1 (2) ◽  
pp. 22-30
Author(s):  
John Frans Sitepu
Keyword(s):  
Clinical Trial ◽  
General Anesthesia ◽  
Randomized Clinical Trial ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Elective Surgery ◽  
Double Blind ◽  
Lidocaine Group ◽  
Throat Pain ◽  
Surgical Pain

Throat pain is a complication that is often found in patients with general anesthesia who use endotracheal intubation that is difficult to control even though surgical pain is well controlled using systemic analgesia. The purpose of this study was to see a comparison of the effectiveness of treatment in the prevention of throat pain in general anesthesia. This study used a double blind randomized clinical trial method conducted at three sites. The sample of this study was all patients who underwent elective surgery with general anesthesia endotracheal intubation. Statistically it was shown that there was no difference in effectiveness between Dexamethason 0.2 mg / kg and Lidocaine 1.5 mg / kgBB, but clinically the incidence of sore throat was higher in the Lidocaine group 1.5 mg / kgBB. Whereas at the 6th hour, Dexamethason 0.2 mg / kgBB statistically is more effective than Lidocaine 1.5 mg / kg in terms of reducing the incidence of sore throat after surgery.

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