Detonation propagation in hydrogen–air mixtures with transverse concentration gradients

Shock Waves ◽  
2015 ◽  
Vol 26 (2) ◽  
pp. 181-192 ◽  
Author(s):  
L. R. Boeck ◽  
F. M. Berger ◽  
J. Hasslberger ◽  
T. Sattelmayer
Keyword(s):  
Concentration Gradients ◽  
Detonation Propagation

On the structural organization of biological pumps and channels

1984 ◽  
Vol 42 ◽  
pp. 138-141
Author(s):  
G. Zampighi ◽  
M. Kreman
Keyword(s):  
Active Transport ◽  
Transport System ◽  
Plasma Membranes ◽  
Transport Proteins ◽  
Molecular Organization ◽  
Passive Transport ◽  
Concentration Gradients ◽  
Cell Functions ◽  
Natural Concentration ◽  
Active Transport System

The plasma membranes of most animal cells contain transport proteins which function to provide passageways for the transported species across essentially impermeable lipid bilayers. The channel is a passive transport system which allows the movement of ions and low molecular weight molecules along their concentration gradients. The pump is an active transport system and can translocate cations against their natural concentration gradients. The actions and interplay of these two kinds of transport proteins control crucial cell functions such as active transport, excitability and cell communication. In this paper, we will describe and compare several features of the molecular organization of pumps and channels. As an example of an active transport system, we will discuss the structure of the sodium and potassium ion-activated triphosphatase [(Na+ +K+)-ATPase] and as an example of a passive transport system, the communicating channel of gap junctions and lens junctions.

Maxwell’s Equations versus Newton’s Third Law

2018 ◽  
Author(s):  
Glyn Kennell ◽  
Richard Evitts
Keyword(s):  
Electric Fields ◽  
Maxwell’S Equations ◽  
Maxwell's Equations ◽  
Simulated Data ◽  
Numerical Data ◽  
Transport Equations ◽  
Concentration Gradients ◽  
Third Law

The presented simulated data compares concentration gradients and electric fields with experimental and numerical data of others. This data is simulated for cases involving liquid junctions and electrolytic transport. The objective of presenting this data is to support a model and theory. This theory demonstrates the incompatibility between conventional electrostatics inherent in Maxwell's equations with conventional transport equations. <br>

NUMERICAL STUDY OF DETONATION PROPAGATION IN VISCOUS TURBULENT FLOW IN A DUCT

2020 ◽  
Author(s):  
V. A. SABELNIKOV ◽  
◽  
V. V. VLASENKO ◽  
S. BAKHNE ◽  
S. S. MOLEV ◽  
...  
Keyword(s):  
Complex Geometry ◽  
Numerical Study ◽  
Navier Stokes ◽  
Detonation Waves ◽  
Detonation Propagation ◽  
Eddy Simulation ◽  
Detonation Structure ◽  
Classical Studies ◽  
Large Eddy ◽  
Physical Effects

Gasdynamics of detonation waves was widely studied within last hundred years - analytically, experimentally, and numerically. The majority of classical studies of the XX century were concentrated on inviscid aspects of detonation structure and propagation. There was a widespread opinion that detonation is such a fast phenomenon that viscous e¨ects should have insigni¦cant in§uence on its propagation. When the era of calculations based on the Reynolds-averaged Navier- Stokes (RANS) and large eddy simulation approaches came into effect, researchers pounced on practical problems with complex geometry and with the interaction of many physical effects. There is only a limited number of works studying the in§uence of viscosity on detonation propagation in supersonic §ows in ducts (i. e., in the presence of boundary layers).

scholarly journals Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53

2021 ◽  
Vol 20 ◽  
pp. 153473542110316
Author(s):  
Liang Wang ◽  
Lei Xu ◽  
Yu Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Methyltransferase ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Concentration Gradients ◽  
A431 Cells

Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor that originates from keratinocytes in the epidermis or appendage. Traditional Chinese medicine Huaier has anti-tumor activity in various malignancies. Little is known about the role of Huaier in CSCC. Here, we investigated the function of Huaier in CSCC. We treated CSCC cell line (SCL-1 and A431) with a series of concentration gradients of Huaier to examine the half maximal inhibitory concentration (IC50) of Huaier on SCL-1 and A431 cells. The IC50 of Huaier on growth of SCL-1 and A431 cells were 6.96 and 7.57 mg/mL, respectively. Moreover, Huaier reduced the methylation levels of CDKN2A and TP53, and enhanced the expression of CDKN2A and TP53 in SCL-1 and A431 cells in a dosage-dependent manner. The expression of DNA methyltransferase DNMT1 was severely repressed by Huaier treatment in SCL-1 and A431 cells. DNMT1 overexpression enhanced the methylation levels of CDKN2A and TP53, and suppressed the expression of CDKN2A and TP53 in Huaier-treated SCL-1 and A431 cells. Huaier treatment inhibited proliferation, migration, and invasion of SCL-1 and A431 cells. However, inhibition of CDKN2A or TP53 reversed the influence of Huaier treatment on proliferation, migration, and invasion of CSCC cells. In conclusion, our data demonstrate that Huaier inhibits proliferation, migration, and invasion of CSCC cells by regulating DNA methylation of CDKN2A and TP53, thereby attenuating the progression of CSCC. Thus, Huaier extract may act as a drug for treating CSCC.

Sign in / Sign up

Export Citation Format

Share Document