Calcitonin suppresses intervertebral disk degeneration and preserves lumbar vertebral bone mineral density and bone strength in ovariectomized rats

2015 ◽  
Vol 26 (12) ◽  
pp. 2853-2861 ◽  
Author(s):  
F.-m. Tian ◽  
K. Yang ◽  
W.-y. Wang ◽  
Y. Luo ◽  
S.-y. Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Strength ◽  
Bone Mineral ◽  
Intervertebral Disk ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Vertebral Bone Mineral Density

Correlation between bone mineral density and intervertebral disk degeneration in pre- and postmenopausal women

2003 ◽  
Vol 21 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Yoshiro Nanjo ◽  
Yasuo Morio ◽  
Hideki Nagashima ◽  
Hiroshi Hagino ◽  
Ryota Teshima
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Intervertebral Disk ◽  
Mineral Density ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration

scholarly journals Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Qi Sun ◽  
Xin-Yu Nan ◽  
Fa-Ming Tian ◽  
Fang Liu ◽  
Shao-Hua Ping ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Lumbar Fusion ◽  
B Cell Lymphoma ◽  
Intervertebral Disk ◽  
Ovariectomized Rats ◽  
Tunel Staining ◽  
Mineral Density ◽  
Vertebral Osteoporosis ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration

Abstract Background Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of nucleus pulposus (NP). Raloxifene (RAL) could delay ASDD by inhibiting NP apoptosis. Methods An ASDD rat model was established by ovariectomy (OVX) and posterolateral spinal fusion (PLF) on levels 4–5 of the lumbar vertebrae. Rats in the treatment groups were administered 1 mg/kg/d RAL by gavage for 12 weeks, following which, all animals were euthanized. Lumbar fusion, apoptosis, ASDD, and vertebrae micro-architecture were evaluated. Results RAL maintained intervertebral disk height (DHI), delayed vertebral osteoporosis, reduced histological score, and inhibited apoptosis. The OVX+PLF+RAL group revealed upregulated expression of aggrecan and B-cell lymphoma-2 (bcl2), as well as significantly downregulated expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), metalloproteinase-13 (MMP-13), caspase-3, BCL2-associated X (bax), and transferase dUTP nick end labeling (TUNEL) staining. Micro-computed tomography (Micro-CT) analysis revealed higher bone volume fraction (BV/TV), bone mineral density (BMD), and trabecular number (Tb.N), and lower trabecular separation (Tb.Sp) in OVX+PLF+RAL group than in the OVX+PLF group. Conclusions RAL can postpone ASDD development in OVX rats through inhibiting extracellular matrix metabolic imbalance, NP cell apoptosis, and vertebral osteoporosis. These findings showed RAL as a potential therapeutic target for ASDD.

Influence of electro-acupuncture on bone mineral density, bone strength and ultrastructure in ovariectomized rats

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 27-28 ◽  
Author(s):  
Z.G. Luo ◽  
A.T. Wang ◽  
W.S. Yu ◽  
Y. Zhao ◽  
P. Hu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Strength ◽  
Bone Mineral ◽  
Ovariectomized Rats ◽  
Mineral Density

Vertebral bone mineral density of the elderly in the urban community by mobile DXA

1994 ◽  
Vol 12 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Takao Suzuki ◽  
Hiroshi Haga ◽  
Seiji Yasumura ◽  
Harumi Nagai ◽  
Hidenori Amano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Urban Community ◽  
The Elderly ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Vertebral Bone Mineral Density

scholarly journals Influence of vertebral bone mineral density on total dispersion volume of bone cement in vertebroplasty

Medicine ◽  
2019 ◽  
Vol 98 (12) ◽  
pp. e14941
Author(s):  
Jun Liu ◽  
Zhenghua Liu ◽  
Jing Luo ◽  
Liqun Gong ◽  
Yaqing Cui ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Cement ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Total Dispersion ◽  
Vertebral Bone Mineral Density

scholarly journals 931 RAPID LOSS OF VERTEBRAL BONE MINERAL DENSITY AFTER HEART TRANSPLANTATION

1994 ◽  
Vol 26 (Supplement) ◽  
pp. S166 ◽  
Author(s):  
R. W. Braith ◽  
M. L. Pollock ◽  
R. M. Mills ◽  
M. A. Welsch ◽  
R. L. Camberg
Keyword(s):  
Bone Mineral Density ◽  
Heart Transplantation ◽  
Bone Mineral ◽  
Mineral Density ◽  
Rapid Loss ◽  
Vertebral Bone ◽  
Vertebral Bone Mineral Density

scholarly journals Noncontrast Cardiac Computed Tomography Image-Based Vertebral Bone Mineral Density

2013 ◽  
Vol 20 (5) ◽  
pp. 621-627 ◽  
Author(s):  
Dong Li ◽  
Song Shou Mao ◽  
Bahram Khazai ◽  
Joseph A. Hyder ◽  
Matthew Allison ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Cardiac Computed Tomography ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Vertebral Bone Mineral Density ◽  
Tomography Image ◽  
Computed Tomography Image

Assessment of Vertebral Bone Mineral Density Using Volumetric Quantitative CT

1999 ◽  
Vol 23 (1) ◽  
pp. 130-137 ◽  
Author(s):  
Thomas F. Lang ◽  
Jing Li ◽  
Steven T. Harris ◽  
Harry K. Genant
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Quantitative Ct ◽  
Vertebral Bone ◽  
Vertebral Bone Mineral Density
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