Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological magnetic resonance imaging

2005 ◽  
Vol 180 (4) ◽  
pp. 743-751 ◽  
Author(s):  
Nicholas Jones ◽  
Michael J. O’Neill ◽  
Mark Tricklebank ◽  
Vincenzo Libri ◽  
Steve C. R. Williams
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Ampa Receptor ◽  
Resonance Imaging

scholarly journals How Stereological Analysis of Vascular Morphology Can Quantify the Blood Volume Fraction as a Marker for Tumor Vasculature: Comparison with Magnetic Resonance Imaging

2011 ◽  
Vol 32 (3) ◽  
pp. 489-501 ◽  
Author(s):  
Adriana T Perles-Barbacaru ◽  
Boudewijn PJ van der Sanden ◽  
Regine Farion ◽  
Hana Lahrech
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Blood Volume ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Simulated Data ◽  
Tumor Model ◽  
Tumor Vasculature ◽  
Resonance Imaging

To assess angiogenesis noninvasively in a C6 rat brain tumor model, the rapid-steady-state- T1 (RSST1) magnetic resonance imaging (MRI) method was used for microvascular blood volume fraction (BVf) quantification with a novel contrast agent gadolinium per (3,6 anhydro) α-cyclodextrin (Gd-ACX). In brain tissue contralateral to the tumor, equal BVfs were obtained with Gd-ACX and the clinically approved gadoterate meglumine (Gd-DOTA). Contrary to Gd-DOTA, which leaks out of the tumor vasculature, Gd-ACX was shown to remain vascular in the tumor tissue allowing quantification of the tumor BVf. We sought to confirm the obtained tumor BVf using an independent method: instead of using a ‘standard’ two-dimensional histologic method, we study here how vascular morphometry combined with a stereological technique can be used for three-dimensional assessment of the vascular volume fraction ( VV). The VV is calculated from the vascular diameter and length density. First, the technique is evaluated on simulated data and the healthy rat brain vasculature and is then applied to the same C6 tumor vasculature previously quantified by RSST1-MRI with Gd-ACX. The mean perfused VV and the BVf obtained by MRI in tumor regions are practically equal and the technique confirms the spatial heterogeneity revealed by MRI.

scholarly journals T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain.

Stroke ◽  
1992 ◽  
Vol 23 (4) ◽  
pp. 576-582 ◽  
Author(s):  
N van Bruggen ◽  
B M Cullen ◽  
M D King ◽  
M Doran ◽  
S R Williams ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Resonance Imaging ◽  
Ischemic Lesion ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
And Diffusion

Pharmacological magnetic resonance imaging of muscarinic acetylcholine receptor activation in rat brain

2010 ◽  
Vol 58 (8) ◽  
pp. 1252-1257 ◽  
Author(s):  
Erik I. Hoff ◽  
Robert J. van Oostenbrugge ◽  
Wim M. Otte ◽  
Kajo van der Marel ◽  
Harry W.M. Steinbusch ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Receptor Activation ◽  
Resonance Imaging ◽  
Muscarinic Acetylcholine

Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature

1991 ◽  
Vol 26 (4) ◽  
pp. 593-597 ◽  
Author(s):  
Andrew B. Norman ◽  
Karl J. Bertram ◽  
Stephen R. Thomas ◽  
Ronald G. Pratt ◽  
R.C. Samaratunga ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Cerebral Vasculature ◽  
Resonance Imaging

scholarly journals Functional magnetic resonance imaging of reorganization in rat brain after stroke

2001 ◽  
Vol 98 (22) ◽  
pp. 12766-12771 ◽  
Author(s):  
R. M. Dijkhuizen ◽  
J. Ren ◽  
J. B. Mandeville ◽  
O. Wu ◽  
F. M. Ozdag ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Rat Brain ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

scholarly journals In vivo chlorine-35, sodium-23 and proton magnetic resonance imaging of the rat brain

2010 ◽  
Vol 23 (6) ◽  
pp. 592-600 ◽  
Author(s):  
Stefan Kirsch ◽  
Mark Augath ◽  
David Seiffge ◽  
Lothar Schilling ◽  
Lothar R. Schad
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Proton Magnetic Resonance ◽  
Resonance Imaging ◽  
Proton Magnetic Resonance Imaging

Magnetic resonance imaging of the rat brain following acute carbon monoxide poisoning

1992 ◽  
Vol 12 (6) ◽  
pp. 407-414 ◽  
Author(s):  
Vishram Jalukar ◽  
David G. Penney ◽  
Michael Crowley ◽  
Nicholas Simpson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Carbon Monoxide ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Carbon Monoxide Poisoning ◽  
Resonance Imaging ◽  
Acute Carbon Monoxide Poisoning
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