Neonatal phencyclidine and social isolation in the rat: effects of clozapine on locomotor activity, social recognition, prepulse inhibition, and executive functions deficits

2020 ◽  
Author(s):  
Al Mahdy Hamieh ◽  
David Babin ◽  
Evelyne Sablé ◽  
Anne Marie Hernier ◽  
Vincent Castagné
Keyword(s):  
Locomotor Activity ◽  
Executive Functions ◽  
Social Isolation ◽  
Prepulse Inhibition ◽  
Social Recognition

scholarly journals Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ryo Saito ◽  
Chika Miyoshi ◽  
Michinori Koebis ◽  
Itaru Kushima ◽  
Kazuki Nakao ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Psychiatric Disorders ◽  
Mouse Models ◽  
Prepulse Inhibition ◽  
Animal Studies ◽  
22Q11.2 Deletion Syndrome ◽  
Social Recognition ◽  
Deletion Syndrome ◽  
Behavioral Tests ◽  
22Q11.2 Deletion

Abstract22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by the segmental deletion of human chromosome 22. This chromosomal deletion is known as high genetic risk factors for various psychiatric disorders. The different deletion types are identified in 22q11.2DS patients, including the most common 3.0-Mb deletion, and the less-frequent 1.5-Mb and 1.4-Mb deletions. In previous animal studies of psychiatric disorders associated with 22q11.2DS mainly focused on the 1.5-Mb deletion and model mice mimicking the human 1.5-Mb deletion have been established with diverse genetic backgrounds, which resulted in the contradictory phenotypes. On the other hand, the contribution of the genes in 1.4-Mb region to psychiatric disorders is poorly understood. In this study, we generated two mouse lines that reproduced the 1.4-Mb and 1.5-Mb deletions of 22q11.2DS [Del(1.4 Mb)/+ and Del(1.5 Mb)/+] on the pure C57BL/6N genetic background. These mutant mice were analyzed comprehensively by behavioral tests, such as measurement of locomotor activity, sociability, prepulse inhibition and fear-conditioning memory. Del(1.4 Mb)/+ mice displayed decreased locomotor activity, but no abnormalities were observed in all other behavioral tests. Del(1.5 Mb)/+ mice showed reduction of prepulse inhibition and impairment of contextual- and cued-dependent fear memory, which is consistent with previous reports. Furthermore, apparently intact social recognition in Del(1.4 Mb)/+ and Del(1.5 Mb)/+ mice suggests that the impaired social recognition observed in Del(3.0 Mb)/+ mice mimicking the human 3.0-Mb deletion requires mutations both in 1.4-Mb and 1.5 Mb regions. Our previous study has shown that Del(3.0 Mb)/+ mice presented disturbance of behavioral circadian rhythm. Therefore, we further evaluated sleep/wakefulness cycles in Del(3.0 Mb)/+ mice by electroencephalogram (EEG) and electromyogram (EMG) recording. EEG/EMG analysis revealed the disturbed wakefulness and non-rapid eye moving sleep (NREMS) cycles in Del(3.0 Mb)/+ mice, suggesting that Del(3.0 Mb)/+ mice may be unable to maintain their wakefulness. Together, our mouse models deepen our understanding of genetic contributions to schizophrenic phenotypes related to 22q11.2DS.

scholarly journals Two Novel Mouse Models Mimicking Minor Deletions in 22q11.2 Deletion Syndrome Revealed the Contribution of Each Deleted Region to Psychiatric Disorders

2020 ◽  
Author(s):  
Ryo Saito ◽  
Chika Miyoshi ◽  
Michinori Koebis ◽  
Itaru Kushima ◽  
Kazuki Nakao ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Psychiatric Disorders ◽  
Mouse Models ◽  
Prepulse Inhibition ◽  
Animal Studies ◽  
Negative Symptoms ◽  
22Q11.2 Deletion Syndrome ◽  
Social Recognition ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by the segmental deletion of human chromosome 22. This chromosomal deletion is known as high genetic risk factors for various psychiatric disorders. The different deletion types are identified in 22q11.2DS patients, including the most common 3.0-Mb deletion, and the less-frequent 1.5-Mb and 1.4-Mb deletions. In previous animal studies of psychiatric disorders associated with 22q11.2DS mainly focused on the 1.5-Mb deletion and model mice mimicking the human 1.5-Mb deletion have been established with diverse genetic backgrounds, which resulted in the contradictory phenotypes. On the other hand, the contribution of the genes in 1.4-Mb region to psychiatric disorders is poorly understood. In this study, we generated two mouse lines that reproduced the 1.4-Mb and 1.5-Mb deletions of 22q11.2DS [Del(1.4Mb)/+ and Del(1.5Mb)/+] on the pure C57BL/6N genetic background. These mutant mice were analyzed comprehensively by behavioral tests, such as measurement of locomotor activity, sociability, prepulse inhibition and fear-conditioning memory. Del(1.4Mb)/+ mice displayed decreased locomotor activity, which possibly reproduces the negative symptoms of schizophrenia. Del(1.5Mb)/+ mice showed reduction of prepulse inhibition and impairment of contextual- and cued-dependent fear memory, which is consistent with previous reports. Furthermore, apparently intact social recognition in Del(1.4Mb)/+ and Del(1.5Mb)/+ mice suggests that the impaired social recognition requires mutations both in 1.4-Mb and 1.5 Mb regions. Our previous study has shown that Del(3.0Mb)/+ mice mimicking the human 3.0-Mb deletion presented disturbance of behavioral circadian rhythm. Therefore, we further evaluated sleep/wakefulness cycles in Del(3.0Mb)/+ mice by electroencephalogram (EEG) and electromyogram (EMG) recording. EEG/EMG analysis revealed the disturbed wakefulness and non-rapid eye moving sleep (NREMS) cycles in Del(3.0Mb)/+ mice, suggesting that Del(3.0Mb)/+ mice may be unable to maintain their wakefulness. Together, our mouse models deepen our understanding of genetic contributions to schizophrenic phenotypes related to 22q11.2DS.

The Effect of Social Isolation on Locomotor Activity in the Houseflies (Musca Domestica)

2015 ◽  
Vol 28 (3) ◽  
pp. 288-296 ◽  
Author(s):  
Kayla McCarthy ◽  
Anders Kjærsgaard ◽  
Simon Bahrndorff ◽  
Toke Munk Schou ◽  
Tommaso Manenti ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Social Isolation ◽  
Musca Domestica

scholarly journals Social isolation impacts late-life socio-cognitive decline in APP/PS1 mice

2019 ◽  
Author(s):  
Eva Rens ◽  
Rudi D’Hooge ◽  
Ann Van der Jeugd
Keyword(s):  
Social Isolation ◽  
Short Term Memory ◽  
Social Recognition ◽  
Long Term Memory ◽  
Dependent Manner ◽  
Term Memory ◽  
Y Maze ◽  
The Social ◽  
Socially Isolated

AbstractIn this study the effects of social isolation (SI) were investigated in APP/PS1 mice. It was found that SI during adolescence has an impact on anxiogenic behaviour, such that isolated animals tend to explore a threatening environment less than non-isolated animals as assessed with the EPM test, and that this holds for both AD and non-AD mice. While no evidence was found for any differences in short-term memory as assessed by the Y-maze, long-term memory seemed to be affected in a context-dependent manner. Object memory as assessed with the NOR test was affected in APP/PS1 mice compared to WT mice, but this deficit was not induced or influenced by SI. When it comes to social recognition memory however, we found that SI exacerbated the social memory deficit in AD mice, and even induced a deficit in WTs. Associative fear memory as assessed with the PA test suggested that WTs perform better when group housed, and APP/PS1 mice better when socially isolated. The link between isolation and AD, or cognition in general, may be more complex than initially thought. The effect of isolation may not be the same for AD versus non-AD subjects.

scholarly journals Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice

2004 ◽  
Vol 142 (3) ◽  
pp. 543-550 ◽  
Author(s):  
Maarten Van Den Buuse ◽  
Margaret Morris ◽  
Carolina Chavez ◽  
Sally Martin ◽  
JianHong Wang
Keyword(s):  
Locomotor Activity ◽  
Prepulse Inhibition

scholarly journals Voluntary locomotor activity mitigates oxidative damage associated with isolation stress in the prairie vole ( Microtus ochrogaster )

2015 ◽  
Vol 11 (7) ◽  
pp. 20150178 ◽  
Author(s):  
Kelsey L. Fletcher ◽  
Brittany N. Whitley ◽  
Lisa A. Treidel ◽  
David Thompson ◽  
Annie Williams ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Social Isolation ◽  
Prairie Vole ◽  
Microtus Ochrogaster ◽  
Isolation Stress ◽  
Oxidative Balance ◽  
The Social ◽  
Social Animals ◽  
Physiological Systems

Organismal performance directly depends on an individual's ability to cope with a wide array of physiological challenges. For social animals, social isolation is a stressor that has been shown to increase oxidative stress. Another physiological challenge, routine locomotor activity, has been found to decrease oxidative stress levels. Because we currently do not have a good understanding of how diverse physiological systems like stress and locomotion interact to affect oxidative balance, we studied this interaction in the prairie vole ( Microtus ochrogaster ). Voles were either pair housed or isolated and within the isolation group, voles either had access to a moving wheel or a stationary wheel. We found that chronic periodic isolation caused increased levels of oxidative stress. However, within the vole group that was able to run voluntarily, longer durations of locomotor activity were associated with less oxidative stress. Our work suggests that individuals who demonstrate increased locomotor activity may be better able to cope with the social stressor of isolation.

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