Quantitative estimation of riluzole in human plasma by LC-ESI-MS/MS and its application to a bioequivalence study

2010 ◽  
Vol 398 (3) ◽  
pp. 1367-1374 ◽  
Author(s):  
Babu Rao Chandu ◽  
Sreekanth Nama ◽  
Kanchanamala Kanala ◽  
Balasekhara Reddy Challa ◽  
Rihana Parveen Shaik ◽  
...  
Keyword(s):  
Human Plasma ◽  
Quantitative Estimation ◽  
Bioequivalence Study ◽  
Esi Ms

scholarly journals Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ravi Kumar Konda ◽  
B. R. Challa ◽  
Babu Rao Chandu ◽  
Kothapalli B. Chandrasekhar
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Method Development ◽  
Dynamic Range ◽  
Quantitative Estimation ◽  
Multiple Reaction Monitoring ◽  
Internal Standard ◽  
Bioequivalence Study ◽  
Healthy Human ◽  
Development And Validation

A simple, sensitive, and rapid HPLC-MS/MS method was developed and validated for quantitative estimation of memantine in human plasma. Chromatography was performed on Zorbax SB-C18(4.6×75 mm, 3.5 μm) column. Memantine (ME) and internal standard Memantine-d6(MED6) were extracted by using liquid-liquid extraction and analyzed by LC-ESI-MS/MS using multiple-reaction monitoring (MRM) mode. The assay exhibited a linear dynamic range of 50.00–50000.00 pg/ml for ME in human plasma. This method demonstrated an intra- and interday precision within the range of 2.1–3.7 and 1.4–7.8%, respectively. Further intra- and interday accuracy was within the range of 95.6–99.8 and 95.7–99.1% correspondingly. The mean recovery of ME and MED6 was86.07±6.87and80.31±5.70%, respectively. The described method was successfully employed in bioequivalence study of ME in Indian male healthy human volunteers under fasting conditions.

LC–ESI-MS/MS method for the quantification of entecavir in human plasma and its application to bioequivalence study

2011 ◽  
Vol 879 (11-12) ◽  
pp. 769-776 ◽  
Author(s):  
Balasekhara Reddy Challa ◽  
Bahlul Z. Awen ◽  
Babu Rao Chandu ◽  
Shaik Rihanaparveen
Keyword(s):  
Human Plasma ◽  
Bioequivalence Study ◽  
Esi Ms

Sildenafil and N-desmethyl sildenafil quantification in human plasma by HPLC coupled with ESI-MS/MS detection: Application to bioequivalence study

2010 ◽  
Vol 2 (8) ◽  
pp. 1043 ◽  
Author(s):  
Balasekhara Reddy Challa ◽  
Bahlul Z. Awen ◽  
Babu Rao Chandu ◽  
Mukkanti Khagga ◽  
Chandrasekhar Kothapalli Bannoth ◽  
...  
Keyword(s):  
Human Plasma ◽  
Bioequivalence Study ◽  
Esi Ms ◽  
Ms Detection

scholarly journals Determination of Nimodipine in Human Plasma by HPLC-ESI-MS and Its Application to a Bioequivalence Study

2010 ◽  
Vol 48 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Y. Zhao ◽  
D. Zhai ◽  
X. Chen ◽  
Q. Yu ◽  
H. He ◽  
...  
Keyword(s):  
Human Plasma ◽  
Bioequivalence Study ◽  
Esi Ms

Quantification of Acamprosate in human plasma by LC-ESI-MS/MS with solid phase extraction: Application to a bioequivalence study

2013 ◽  
Vol 7 (5) ◽  
pp. 389-396 ◽  
Author(s):  
Kanchana Mala Kanala ◽  
Babu Rao Chandu ◽  
Nagiat T. Hwisa ◽  
Mukkanti Khagga ◽  
Prakash Katakam ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Bioequivalence Study ◽  
Phase Extraction ◽  
Esi Ms
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