Chronic intracerebroventricular exposure to β-amyloid(1-40) impairs object recognition but does not affect spontaneous locomotor activity or sensorimotor gating in the rat

2001 ◽  
Vol 136 (1) ◽  
pp. 93-100 ◽  
Author(s):  
S. Nag ◽  
F. Tang ◽  
B.K. Yee
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Sensorimotor Gating ◽  
Spontaneous Locomotor Activity ◽  
Β Amyloid

scholarly journals Rats Exposed to Isoflurane In Utero  during Early Gestation Are Behaviorally Abnormal as Adults

2011 ◽  
Vol 114 (3) ◽  
pp. 521-528 ◽  
Author(s):  
Arvind Palanisamy ◽  
Mark G. Baxter ◽  
Pamela K. Keel ◽  
Zhongcong Xie ◽  
Gregory Crosby ◽  
...  
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Elevated Plus Maze ◽  
Fetal Brain ◽  
In Utero ◽  
Spontaneous Locomotor Activity ◽  
Radial Arm Maze ◽  
Second Trimester ◽  
Adult Rats ◽  
Plus Maze

Background Preclinical evidence suggests that commonly used anesthetic agents induce long-lasting neurobehavioral changes when administered early in life, but there has been virtually no attention to the neurodevelopmental consequences for the fetus of maternal anesthesia. This study tested the hypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, which corresponds to the second trimester in humans, would be behaviorally abnormal as adults. Methods Timed, pregnant rats were randomly assigned on gestational day 14 to receive 1.4% isoflurane in 100% oxygen (n = 3) or 100% oxygen (n = 2) for 4 h. Beginning at 8 weeks of age, male offspring (N = 12-14 in control and anesthesia groups, respectively) were evaluated for spontaneous locomotor activity, hippocampal-dependent learning and memory (i.e., spontaneous alternations, novel object recognition, and radial arm maze), and anxiety (elevated plus maze). Results Isoflurane anesthesia was physiologically well tolerated by the dams. Adult rats exposed prenatally to isoflurane were not different than controls on spontaneous locomotor activity, spontaneous alternations, or object recognition memory, but made more open arm entries on the elevated plus maze and took longer and made more errors of omission on the radial arm maze. Conclusions Rats exposed to isoflurane in utero at a time that corresponds to the second trimester in humans have impaired spatial memory acquisition and reduced anxiety, compared with controls. This suggests the fetal brain may be adversely affected by maternal anesthesia, and raises the possibility that vulnerability to deleterious neurodevelopmental effects of isoflurane begins much earlier in life than previously recognized.

scholarly journals β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

Cell ◽  
1995 ◽  
Vol 81 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Hui Zheng ◽  
Minghao Jiang ◽  
Myrna E. Trumbauer ◽  
Dalip J.S. Sirinathsinghji ◽  
Ruth Hopkins ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Reactive Gliosis ◽  
Β Amyloid ◽  
Deficient Mice

scholarly journals Spontaneous Locomotor Activity and Life Span

Gerontology ◽  
1985 ◽  
Vol 31 (5) ◽  
pp. 335-337 ◽  
Author(s):  
F.A. Lints ◽  
E. Le Bourg ◽  
C.V. Lints
Keyword(s):  
Locomotor Activity ◽  
Life Span ◽  
Spontaneous Locomotor Activity

Drug interactions on spontaneous locomotor activity in rats

1984 ◽  
Vol 23 (8) ◽  
pp. 909-914 ◽  
Author(s):  
G.J. Schaefer ◽  
R.P. Michael
Keyword(s):  
Locomotor Activity ◽  
Drug Interactions ◽  
Spontaneous Locomotor Activity

scholarly journals Global brain volume reductions in a sub-chronic phencyclidine animal model for schizophrenia and their relationship to recognition memory

2019 ◽  
Vol 33 (10) ◽  
pp. 1274-1287 ◽  
Author(s):  
Nazanin Doostdar ◽  
Eugene Kim ◽  
Ben Grayson ◽  
Michael K Harte ◽  
Joanna C Neill ◽  
...  
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Brain Volume ◽  
Perirhinal Cortex ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Exploration ◽  
Brain Changes ◽  
Global Brain ◽  
Structural Brain

Background: Cognitive deficits and structural brain changes co-occur in patients with schizophrenia. Improving our understanding of the relationship between these is important to develop improved therapeutic strategies. Back-translation of these findings into rodent models for schizophrenia offers a potential means to achieve this goal. Aims: The purpose of this study was to determine the extent of structural brain changes and how these relate to cognitive behaviour in a sub-chronic phencyclidine rat model. Methods: Performance in the novel object recognition task was examined in female Lister Hooded rats at one and six weeks after sub-chronic phencyclidine (2 mg/kg intra-peritoneal, n=15) and saline controls (1 ml/kg intra-peritoneal, n=15). Locomotor activity following acute phencyclidine challenge was also measured. Brain volume changes were assessed in the same animals using ex vivo structural magnetic resonance imaging and computational neuroanatomical analysis at six weeks. Results: Female sub-chronic phencyclidine-treated Lister Hooded rats spent significantly less time exploring novel objects ( p<0.05) at both time-points and had significantly greater locomotor activity response to an acute phencyclidine challenge ( p<0.01) at 3–4 weeks of washout. At six weeks, sub-chronic phencyclidine-treated Lister Hooded rats displayed significant global brain volume reductions ( p<0.05; q<0.05), without apparent regional specificity. Relative volumes of the perirhinal cortex however were positively correlated with novel object exploration time only in sub-chronic phencyclidine rats at this time-point. Conclusion: A sustained sub-chronic phencyclidine-induced cognitive deficit in novel object recognition is accompanied by global brain volume reductions in female Lister Hooded rats. The relative volumes of the perirhinal cortex however are positively correlated with novel object exploration, indicating some functional relevance.

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