Evidence for the modulation of spontaneous locomotor activity by higher serum glucose levels and/or spleen-derived factor(s) in diabetic mice

This study was designed to test the lipid-lowering and antidiabetic activities of olive leaf and its callus extract. Diabetes in mice was induced by intraperitoneal injections of alloxan. The serum glucose and serum lipid were examined. Diabetic mice showed hypeglycemia, hypelipidemia. The administration, for 2 weeks of olive leaf and its callus extracts significantly decreased the Total cholesterol (TC). Triglycerides (TG). Low density lipoprotein (LDL), very low density lipoprotein (VLDL). Both types of olive extracts had significant hypoglycemic effects on blood glucose levels in diabetic mice. This hypoglycemic effect was as potent as the hypoglycemic effect of insulin. However, the callus extract was more potent than the leaves extracts and most potent than insulin in causing a significant decrease in LDL, VLDL, TC, TG and in antidiabetic effects.

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Lectin fromCrataeva tapiaBark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/869305 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Amanda Alves da Rocha ◽

Tiago Ferreira da Silva Araújo ◽

Caíque Silveira Martins da Fonseca ◽

Diógenes Luís da Mota ◽

Paloma Lys de Medeiros ◽

...

Keyword(s):

Folk Medicine ◽

Intraperitoneal Administration ◽

Serum Glucose ◽

Exchange Chromatography ◽

Diabetic Mice ◽

Progressive Decline ◽

Glucose Levels ◽

Patients With Diabetes ◽

Tissue Damages ◽

Treatment Of Diabetes

Crataeva tapiais a plant popularly used for diabetes treatment, in Brazil. Progressive decline in renal and hepatic functions has been described in patients with diabetes mellitus, and mortality rate is increased in patients with chronic liver and renal disease. This study aimed to evaluate whetherCrataeva tapiabark lectin (CrataBL) improves hyperglycemia and renal and hepatic damage in diabetic mice. CrataBL was purified by ion exchange chromatography on CM-cellulose, and intraperitoneal administration of CrataBL to alloxan-induced diabetic mice at dose of 10 mg/Kg/day and 20 mg/Kg/day for 10 days significantly reduced serum glucose levels by 14.9% and 55.9%, respectively. Serum urea, creatinine, aspartate aminotransferase, and alanine aminotransferase were also significantly reduced after treatment with both doses of CrataBL. Furthermore, histological analysis of liver, kidney, and pancreas revealed an improvement in the tissue morphology upon treatment with CrataBL. The results suggest that CrataBL has a beneficial hypoglycemic activity and improves the renal and hepatic complications of diabetes. Therefore, this lectin may be a promising agent for the treatment of diabetes, and this might be the basis for its use in the folk medicine as an alternative treatment to manage diabetes-related complications such as hyperglycemia and tissue damage.

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Glucose lowering by SGLT2-inhibitor empagliflozin accelerates atherosclerosis regression in hyperglycemic STZ-diabetic mice

Scientific Reports ◽

10.1038/s41598-019-54224-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Jan Pennig ◽

Philipp Scherrer ◽

Mark Colin Gissler ◽

Nathaly Anto-Michel ◽

Natalie Hoppe ◽

...

Keyword(s):

Leukocyte Adhesion ◽

Plasma Cholesterol ◽

Sglt2 Inhibitor ◽

Vascular Wall ◽

High Cholesterol Diet ◽

Chow Diet ◽

Diabetic Mice ◽

Glucose Lowering ◽

Atherosclerosis Progression ◽

Glucose Levels

AbstractDiabetes worsens atherosclerosis progression and leads to a defect in repair of arteries after cholesterol reduction, a process termed regression. Empagliflozin reduces blood glucose levels via inhibition of the sodium glucose cotransporter 2 (SGLT-2) in the kidney and has been shown to lead to a marked reduction in cardiovascular events in humans. To determine whether glucose lowering by empagliflozin accelerates atherosclerosis regression in a mouse model, male C57BL/6J mice were treated intraperitoneally with LDLR- and SRB1- antisense oligonucleotides and fed a high cholesterol diet for 16 weeks to induce severe hypercholesterolemia and atherosclerosis progression. At week 14 all mice were rendered diabetic by streptozotocin (STZ) injections. At week 16 a baseline group was sacrificed and displayed substantial atherosclerosis of the aortic root. In the remaining mice, plasma cholesterol was lowered by switching to chow diet and treatment with LDLR sense oligonucleotides to induce atherosclerosis regression. These mice then received either empagliflozin or vehicle for three weeks. Atherosclerotic plaques in the empagliflozin treated mice were significantly smaller, showed decreased lipid and CD68+ macrophage content, as well as greater collagen content. Proliferation of plaque resident macrophages and leukocyte adhesion to the vascular wall were significantly decreased in empagliflozin-treated mice. In summary, plasma glucose lowering by empagliflozin improves plaque regression in diabetic mice.

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Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats

Bioscience Biotechnology and Biochemistry ◽

10.1080/09168451.2014.951025 ◽

2014 ◽

Vol 79 (1) ◽

pp. 109-116 ◽

Cited By ~ 18

Author(s):

Fuminori Kawabata ◽

Takafumi Mizushige ◽

Keisuke Uozumi ◽

Kohsuke Hayamizu ◽

Li Han ◽

...

Keyword(s):

Protein Intake ◽

Muscle Hypertrophy ◽

Serum Glucose ◽

Fast Muscle ◽

Fish Protein ◽

Liver Lipids ◽

Glucose Levels

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Defatted Hydroethanolic Extract of Ammodaucus leucotrichus Cosson and Durieu Seeds: Antidiabetic and Anti-Inflammatory Activities

Applied Sciences ◽

10.3390/app10249147 ◽

2020 ◽

Vol 10 (24) ◽

pp. 9147

Author(s):

Imane Es-Safi ◽

Hamza Mechchate ◽

Amal Amaghnouje ◽

Anna Calarco ◽

Smahane Boukhira ◽

...

Keyword(s):

Wistar Rats ◽

Fasting Blood Glucose ◽

Diabetic Mice ◽

North African ◽

Glucose Levels ◽

The North ◽

Blood Glucose Levels ◽

Anti Inflammatory ◽

Hydroethanolic Extract ◽

Inflammatory Effect

The seeds of Ammodaucus leucotrichus Cosson and Durieu have been used in the North African Sahara as a traditional medicine to treat diabetes. The present study investigates the antidiabetic, antihyperglycemic, and anti-inflammatory properties of the defatted hydroethanolic extract of Ammodaucus leucotrichus (DHEAM). The antidiabetic and the antihyperglycemic studies were assessed on alloxan-induced diabetic with orally administered doses of DHEAM (100 and 200 mg/kg). At the same time, its anti-inflammatory propriety was evaluated by measuring edema development in the Wistar rats paw induced with carrageenan. Treatment of diabetic mice with DHEAM for four weeks managed their high fasting blood glucose levels, improved their overall health, and also revealed an excellent antihyperglycemic activity. Following the anti-inflammatory results, DHEAM exhibited a perfect activity. HPLC results revealed the presence of seven molecules (chlorogenic acid, 3-p-coumaroylquinic acid, gallic acid, ferulic acid, myricetin, quercetin, luteolin). This work indicates that the DHEAM has an important antidiabetic, antihyperglycemic, and anti-inflammatory effect that can be well established as a phytomedicine to treat diabetes.

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